Medical Ethics

E-book

Dominik Šafčák

Both clinical and radiation oncology are the most developing parts of medicine. Regardless of the physician´s specialization, all of them will have to face subjects with cancer in their daily clinical practice. It includes not only the treatment itself, but also obtaining the diagnosis, but also differential diagnosis and treatment of different adverse events caused by oncological treatment. This publication provides basic data about tumor characteristics necessary for oncologists to determine the final stage and choose the best treatment strategy. In addition, explains the basic oncological terms, forms of therapy, and provides information about treatment timing, combination strategies and expected outcomes. It explains main endpoints of clinical trials performed in oncology to understand them.  In the second part this publication describes mechanism of action of all treatment modalities used in clinical oncology, provides information about potential side effects and basic knowledge how to deal with them. The last chapter is focused on palliative care, how to relieve symptoms of dying patient and how to deal with cancer-related pain. 

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E-book

Daniela Filakovská- Shoshana Chovan- Zuzana Dankulincová

Dnes sú to už celé generácie odopierania príležitostí pre napĺňanie potenciálu a storočia diskriminácie, ktoré oberajú deti v marginalizovaných komunitách o detstvo tak ako ho poznáme my ostatní, ktorí sme mali viac „šťastia“. Tak, ako sa generácie ľudí v marginalizovaných komunitách točia v kruhu chudoby, z ktorého niet ľahkej cesty, tak sa aj my točíme v bludnom kruhu hľadania vinníkov a odovzdávania si predsudkov a stereotypov založených na mylných predpokladoch, ktoré sú tak zakorenené a samozrejmé, že mnohých ľudí ani nenapadne o nich pochybovať, spochybňovať ich logiku, či sa snažiť ich vyvracať. Spoločnosť na základe vlastných ideálov s ľahkosťou súdi matky či otcov, že nie sú dosť dobrí. Omnoho ťažšia cesta je však snažiť sa pochopiť, čo im v tom bráni. Povedať, že za stratené detstvo detí v marginalizovaných komunitách môžu rodičia, je príliš zjednodušené a nezohľadňuje to omnoho širší kontext a súvislosti. A práve vplyv tohoto kontextu na raný vývin a hľadanie súvislostí je naším cieľom. Nielen preto, že si uvedomujeme potrebu búrať stereotypy a meniť spoločenský diskurz, no najmä preto, aby sme vedeli priniesť dôkazy, na základe ktorých bude možné tvoriť politiky, smerovať intervencie a pomôcť tak ďalším generáciám detí dosiahnuť na príležitosti, ktoré im umožnia naplniť svoj plný potenciál.

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Vladimíra Tomečková

Nature, as well as the human body, contains an abundant quantity of organic molecules. This textbook describes selected oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds of their reactions, which are important in the human body or are found in pharmaceutical active substances, poisons, foodstuffs and heat-treated food. The last part of the textbook describes the isomerism of organic compounds, which enables dynamic changes in the structure of molecules that have different properties. Nature is filled with different plants and animals and is the first laboratory to produce bioactive organic natural compounds. These compounds are compatible with human cells and are applicable as therapeutic medicine. There is an effort to reproduce natural molecules in chemical laboratories, but they cannot be as perfect as the natural ones. Synthetic molecules can serve as a model for multiple studies, but there still does not exist a magic panacea pill or a perfect copy of nature, for the treatment of various diseases. Knowledge about the regenerative and toxic effect of medicinal substances in dependence on their structure (type and number of substituents) is very important for the understanding of their role in modulation of health and disease in dependence on their concentration. Compounds can be used daily only in recommended doses (higher doses can be toxic), but still will not replace a healthy diet. People need a varied diet to be healthy, in which are all necessary nutrients, what Hippocrates demonstrated long ago “Let food be the medicine, and let medicine be the food.” This book is written for students who select bioorganic chemistry subject during the study of general medicine or dentistry as well as for motivated students who would like to practice their knowledge and wish to improve in this subject and for students who would like to learn simplified basic organic reactions with their future application in biochemistry. Learn the simple models mainly through creative simple instruction by using different colours, by repetition, practice by drawing of formulas by hand (at least three times) and memorization of common names of compounds and their reactions which have application in biochemistry. Thus, establishing simple educational methods how to distinguish organic molecules according to the colours of a functional group can promote universal learning for all students who thought that chemistry is a difficult subject, but hopefully they change their opinion after study of this book.

Keywords: organic molecules, oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds, chemical reactions, isomerism of organic compounds

E-book

Katarína Tokarčíková

The university textbook entitled "Vasculitis" provides a systematic overview of vasculitis encountered in clinical practice. The text is supplemented with tables reflecting the latest recommendations of professional societies and illustrations that aid in understanding the subject matter. The individual chapters analyze the etiopathogenesis of individual types of vasculitis, their epidemiology, clinical symptoms, diagnosis, differential diagnosis, treatment, prognosis and also prevention and screening options. The publication is intended for doctoral students at medical faculties, but it can also be used by doctors in specialist training in internal medicine, angiology, cardiology, rheumatology, nephrology and general medicine.

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