CYTOCHROME P-450: genetic and population aspects

E-publication

Beáta Grešš HalászMária Sováriová SoósováMartin ČervenýJana Michalková

The aim of this university textbook is to provide a systematically structured teaching text focused on research in health sciences and, at the same time, to offer a practical methodological manual for writing final theses intended for students of medical and non-medical fields of study. The first chapter introduces the topic, maps the historical development of research in medical and non-medical sciences, and explains the concept of evidence-based practice (EBP) in the context of research activities. It also highlights the importance of research for these fields and describes the individual steps, principles, and methodological procedures of scientific work. The second chapter focuses on the basic attributes of research in health sciences, with an emphasis on key definitions, basic research designs, the typology of scientific studies, and the possibilities for using the relevant methodologies. It also includes the interpretation and analytical processing of quantitative data, while the third chapter analogously elaborates on the qualitative research approach. The fourth chapter is devoted to the ethical aspects of scientific research. The fifth chapter focuses on the evaluation of research papers in terms of their quality, structure, content coherence, reliability, and validity. The final sixth chapter provides methodological guidelines for planning, implementing, and processing individual types of final theses, with the aim of offering students practical and clearly structured instructions for their preparation. The publication also includes questions, tasks, and exercises that supplement theoretical knowledge with practical examples. These cases are intended to develop students' ability to design research studies and methodologically correctly prepare final theses.

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Silvia Danková - Valéria Parová - Gabriela Štefková - Libuša Tirpáková

This university textbook is intended for students of the field of nursing and brings closer the issues in selected clinical fields of nursing, namely dermatovenerology, ophthalmology, otorhinolaryngology and dentistry.

It focuses on the characterization, management of care, reporting and dispensing of specific diseases and nursing care of selected diseases in these fields. It provides important information on the implementation of specific investigative methods and nursing activities that reflect the latest knowledge of the profession, professional guidelines and evidence-based practice.

The authors used relevant sources of domestic and foreign literature as well as electronic sources, which are listed at the end of individual chapters, when processing individual topics. The aim of the authors was to create a university textbook that would help nursing students to orientate themselves in the mentioned clinical fields, or could also be beneficial for nurses in practice.

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Tatiana Kimáková

This scientific monograph is a comprehensive scientific work focused on the presence and effects of mercury in the environment, as well as the health risk factors associated with it.

The monograph presents a characterization of mercury in a multidisciplinary scope, discusses its use in industry and healthcare, and describes the negative impacts of mercury on the environment and public health. It also provides proposals and recommendations for at-risk groups. The monograph includes a comprehensive study of mercury concentration in samples of domestic and foreign production commodities and plant samples using the atomic absorption spectrometer AMA 254.

This scientific monograph is suitable for the scientific community, students of medical, veterinary, natural sciences, and agricultural fields, as well as public health students at all three levels of university study. It is also intended for all interested members of the informed public.

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Lucia Dimunová - Jana Michalková - Gabriela Štefková - Mária Zamboriová

Following innovative trends in university education, this academic textbook offers guidance to update and make the educational process more attractive for all healthcare professions. It applies critical thinking and strategic method of concept mapping in teaching, which are suitable tools for the facilitator and the educant to achieve the desired goal. Critical thinking is an essential academic skill upon which other knowledge and intellectual virtues can be built. It is also an essential equipment for every graduate of the healthcare profession.

The textbook is complemented by a chapter focusing on methods for structural and formative assessment of learning outcomes. The publication is also enriched with sample digital concept maps of which cognitive content can be edited and graphically modified.

The aim of this academic textbook is to present a way of acquiring knowledge through critical thinking using concept mapping as a method, with the final goal of implementing the acquired knowledge into everyday practice.

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Michal Legiňa kol.

Progress in biology and medicine has always been significantly related to advances in physics. Not only has physics supplied instruments and methods of measurement that have led to many discoveries in physiology and medicine, but methods of physical research have changed many of the older approaches to the biologic sciences. Such circumstances have even led to development of a new scientific field: biophysics, which uses to a great extent physical instrumentation procedures applied to an experimental system. Because any instrument is an additional factor in any experimental system, it may affect the data. To interpret physical data on biological material correctly then, it is necessary to consider the characteristics of instrument response.

A practical course enables a student to acquire some skills, experience and methodological knowledge for performance of experiments and evaluation of measured data. Due to the fast development of instrumentation technology, it is not possible to teach every operation and procedure upon instruments we may use in a future. Besides the basic physical principles, the aim of a practical course is to point out some general rules and skills for instrument operation and for the interpretation of the measured values derived from such operation.

There are two kinds of lessons in practical courses. The first one focuses on laboratory measurements of some important physical quantities and the evaluation of the measured data. These measured quantities are components of the subject “medical biophysics” or of the phenomena studied. Experience provided in managing various scales and tables, as well as in the construction of tables and graphs is substantial. Lessons also enable students to repeat and to strengthen their knowledge of secondary school physics, which is useful for understanding of many phenomena studied in medical biophysics. The second kind of lesson provides experience with some of the diagnostic and therapeutic medical instruments, which can be seen in practical medicine.

The understanding of basic physical principles of corresponding instruments is both recommended and demanded. Theoretical preparation is not only an appropriate condition for the practical managing of the whole lesson, but also helps to avoid injury. This textbook, therefore, intends to help students in preparing for both the practical lessons and the final exam.

Authors

Magdaléna Hagovská a kol. 

Vysokoškolská učebnica Praktická kinezioterapia je určená fyzioterapeutom v rámci pregraduálneho, ale aj postgraduálneho vzdelávania. Je komplexne prepracovanou, opravenou a rozšírenou publikáciou pôvodného textu skrípt Najčastejšie používané liečebné metodiky pre fyzioterapeutov (Hagovská, Mihalečková, 2012).
Fyzioterapia sa dotýka takmer všetkých základných klinických odborov. Z toho vyplýva, že fyzioterapeuti by mali ovládať základné poznatky o špeciálnych metódach, ktoré sa zaoberajú fyzioterapiou vertebrologických a neurologických pacientov, pacientov s ortopedickým ochorením, s gynekologickými a urologickými problémami, a pacientov s psychosomatickou diagnózou. Väčšina popísaných najznámejších 44 liečebných metód obsahuje obrázkovú prílohu, na základe ktorej študenti dokážu lepšie pochopiť uvádzané techniky a predísť chybnému vykonávaniu jednotlivých techník.

Autori

E-book

Adriana Boleková (ed.)

Proceedings of Scientific Works

The Košice Morphological Day is an annual May meeting of morphologists, primarily attended by Košice morphological workplaces. On this occasion, a collection of scientific works is regularly published.

This year's collection was published on the occasion of the 23rd Košice Morphological Day, which did not take place due to the poor epidemiological situation.

In the collection, the authors present the results of their scientific-research and pedagogical activities, which are in the form of theoretical overview studies and research works.

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Silvia Mišíková

This learning text deals with heart rhythm disorders. The book is intended for medical students. There are in a simple way characterized bradycardic and tachycardic heart rhythm disorders. The script explains mechanism of arrhythmias, symptoms, diagnostics, and differential diagnostics and treatment. The greatest emphasis is focused on detection of the arrhythmias based on the surface ECG. All arrhythmias are explained by clinical ECG.

In conclusion, there is ECG quiz which consists of 27 clinical ECG records.

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 Ingrid Schusterová 

To offer our medical students of 5th and 6th classes as well as to professional public (pediatrics, pediatric cardiologists) integrated information from pediatric cardiology, which is based on scientific knowledge of experts and practical requirements including our experiences. The publication will extend given the discipline of cardiovascular risk factors of cardiovascular heart disease and acquired heart diseases, which are more actual at the present time in the children as we as bring the new didactic methods in pediatric cardiology teaching.

Autor

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Kvetoslava Rimárová

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Erik Dosedla

Laparoscopic surgical techniques are among the most frequently performed operations today. Throughout their short history, they have undergone many modifications, mainly related to miniaturization and the development of computer technology. The rapid development of laparoscopy over the last twenty years has led to changes in the indications, with minimally invasive procedures gradually replacing standard classical procedures.

Laparoscopic surgery offers significant benefits to the patient, but it also increases the demands on the surgical team.

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Marek Stupák et al.

Medical Chemistry presents an overview of the most important topics of general, organic and bioinorganic chemistry for students of General and Dental Medicine study programs. Its aim is to provide a theoretical basis for the study of the subject Medical Chemistry and for understanding processes and chemical reactions which are taking place in the human body.

Each topic directly links chemical principles to the processes in living organisms and thus can help the students to clearly see the application of the presented information. Therefore, it also provides a good starting point for further study of Medical Biochemistry, for which the knowledge of these principles is necessary.

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M.Stupák - P.Urban - J.Mašlanková - M.Mareková

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Nikita Bobrov et al.

History of ethics represents a search for basic principle, which would enable a distinction between moral and immoral, good and bad, right and wrong. The main problem lies in motives, methods and consequences of human conduct. The integrity of medical profession puts emphasis on life-long study and practice according to the professional competence, and last but not least on ethical principles and rules of medical ethics.
Medical ethics, as a part of bioethics, is currently taking on a huge importance in everyday clinical practice and must face many serious ethical issues regarding the whole system of health care. On general level the decision-making in medical practice is quite easy, based on the requirement to always act in the patient's best interest. However, it is often difficult to know exactly what is best for the patient, in a certain situation, for this particular patient. Also with each progress in medicine and its globalization, the more aspects of human lives are being affected.

Biomedical research, and the new treatment and diagnostic methods it provides are viewed differently in each country, therefore various cultural, religious, social and legal aspects must be considered in their assessment, as well as the basic principles of medical ethics. Worldwide effort on unifying ethical regulations on certain aspects of health care led to the establishment of many legally recognized documents the doctors must be familiar with.

Teaching ethics to students of medical school aims to educate the future doctors towards ethical decision-making, behaviour and professional conduct according to the basic principles of medical ethics.
This textbook provides the basic information on medical ethics for students of medical faculties and serves as a practical introduction to the most common ethical problems of health care provision for their future professional practise.

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Martina Ružičková - Jozef Dragašek

 MEFANET 

Psychology is becoming increasingly important in people's lives. It is significant to research human behaviour and how people interact with their environment, as well as how they develop physically, mentally, emotionally, and socially. A rising number of people have been both physically and mentally harmed in recent years as a result of cognitive, emotional, or behavioural disorders.

It was determined that a study book on psychology for medical students was required. Presented study book Psychology in Medicine gives students a fundamental insight into patients´ behaviour in general, and demonstrates the role of psychology in relieving health concerns in particular. It includes topics of medical psychology and clinical psychology that are applied in health care. The chapters address the basic principles of human behaviour, communication between patients and physicians, personality psychology, psychodiagnostic techniques, psychotherapy treatment, abnormal psychology, dealing with stressful events and physical illnesses. The study textbook also emphasises the importance of good mental health and self-care in a doctor's practise.

There is a hope that this book will provide both a source of information and inspiration for doctors and all health care professionals.

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Tatiana Kimáková - Vladimír Pavlík

The scientific monograph focuses on the characteristics of free radicals, reactive oxygen and nitrogen species, oxidative stress, and its impact on various diseases. A significant portion is dedicated to antioxidants, their classification based on multiple criteria, the characteristics of selected antioxidants in terms of their functions, manifestations of their deficiency and excess, and the overall antioxidant capacity of the body.

A special section is devoted to enzyme-based antioxidants, natural sources of antioxidants in the form of vitamins, trace elements, flavonoids, polyphenols, and coenzyme Q10. To provide a clearer understanding of antioxidants and their influence on population health, the monograph presents results from a research project included in the program "Research Support for Enhancing the Defense Capabilities of the Czech Republic in NATO Structures."

The research was conducted between 2010 and 2012 as part of preventive rehabilitation programs for professional soldiers with a sports component. The study involved 218 professional soldiers, including 180 men and 38 women, with an average age of 33.3 years. The current health status and dietary habits of the soldiers were assessed using questionnaires.

The study described the saturation of the observed group with antioxidant vitamins and statistically evaluated the relationship between their levels and the risk indicators for the development of cardiovascular diseases. Individual analyses were performed using the Reflotron device calibrated with Reflotron Precinorm control serum. Following blood collection, all participants underwent anthropometric examinations (body weight, height, waist circumference), blood pressure measurements, heart rate monitoring, and physical fitness assessments through simple functional tests.

This scientific monograph is suitable for the scientific community, students of medical, veterinary, and natural sciences, as well as public health students at all levels of university education. It is also intended for informed members of the public.

Authors

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