CYTOCHROME P-450: genetic and population aspects

E-publication

Terézia Hudáková-Ján Šalagovič-Jozef Židzik

The Textbook of Medical Biology and Genetics for Bachelor's Study Programs is a comprehensive academic resource tailored to the curriculum of undergraduate courses at the Faculty of Medicine, Pavol Jozef Šafárik University in Košice. Each of the 15 chapters begins with a concise theoretical overview, followed by a carefully selected set of practical exercises and model examples designed to promote active learning and critical thinking. This publication aims to serve as an essential companion for students, supporting their understanding of key concepts and enhancing their preparation for coursework and examinations in designated bachelor's programs.

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Alžbeta Blichárová a kolektív

“Pathology Part 1 (winter semester) - Practical lessons for students of dental medicine” represents the first half of the university textbook designed for the pregradual study of pathology. The textbook complements the lectures of pathology and serves as a source of information for students of dental medicine, that are preparing for the practical as well as the final oral examination.

In this part of the “Pathology” series, fifty-four selected histopathological slides are presented. Each selected slide is provided with general information in relation to etiology and pathogenesis of the disease, as well as with corresponding morphological features, including the gross appearance and the most important histopathological characteristics. The textbook summarizes the basic concepts of general pathology that are necessary to master the broad field of systemic pathology in the second semester.

Mária Pallayová - Štefan Kujaník

The “Textbook of Practical Physiology, Part I - Cardiovascular Physiology” by Mária Pallayová and Štefan Kujaník is a practical textbook of Human Physiology intended for English speaking medical students from general medicine and dentistry curricula.

The textbook covers basic principles in cardiovascular physiology and methods of the cardiovascular examination. Adequate knowledge of the cardiovascular physiology is important for the understanding of cardiovascular system function, as well as for the diagnosis and proper treatment of cardiovascular and other diseases. The practical tasks are constructed to facilitate knowledge acquisition and encourage students to develop practical skills, for instance the ability to follow experimental protocols, to work as part of a team, and to interpret data.

The textbook is written in English and comprises 91 pages in B5 format, grouped into twelve chapters. Each chapter is divided into six sections (Introduction, Principle, Importance, Materials, Procedure, and Protocol) to facilitate students’ understanding of the topics and assist them with preparation of the laboratory reports. The text is accompanied by explanatory figures, graphs, and tables that contribute to the learning experience.

Authors

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Katarína Tokarčíková

The university textbook entitled "Vasculitis" provides a systematic overview of vasculitis encountered in clinical practice. The text is supplemented with tables reflecting the latest recommendations of professional societies and illustrations that aid in understanding the subject matter. The individual chapters analyze the etiopathogenesis of individual types of vasculitis, their epidemiology, clinical symptoms, diagnosis, differential diagnosis, treatment, prognosis and also prevention and screening options. The publication is intended for doctoral students at medical faculties, but it can also be used by doctors in specialist training in internal medicine, angiology, cardiology, rheumatology, nephrology and general medicine.

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Zuzana Dankulincová, Daniela Husárová

In the context of the deteriorating state of adolescent mental health, it is extremely important to optimize the existing mental health care system in Slovakia. There is still little comprehensive and coherent information about the functioning of the system and the process of providing assistance within professional care, its shortcomings or suggestions for improvement. This is not possible without a deep knowledge of the perspective and experiences of adolescents with mental problems themselves. The aim of this publication is therefore to present adolescents' views on the professional assistance provided as a result of experienced mental problems within the existing care system in Slovakia.

The findings from a qualitative study that focused on the views of young people themselves are presented. The chapters of the monograph capture their views on the perception of mental health problems in society, their experiences with identifying emerging problems and seeking professional help, and their experiences with the care process itself and its forms. They also capture their overall experience with both care and care providers, as well as with leaving care and its impacts in various areas. Finally, a view is presented of possible recommendations that could improve the mental health care provided from the adolescents' perspective.

This publication is intended primarily for all professionals working with adolescents with mental health problems in all branches of care, teachers and other educational staff who are in contact with them every day at school, and last but not least, all competent policy makers who care about the mental health of adolescents and have the power to improve the care provided to them.

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Darina Kluchová a kol. 

An illustrated text for dental students

Ingrid Madárová - Lívia Barnišinová - Veronika Pálová

Táto učebnica je určená pre zahraničných študentov medicíny – začiatočníkov – ako slovenčina na špecifický účel výučby. Jej cieľom je pomôcť zahraničným študentom, ktorí (1) študujú medicínu (2) v cudzom jazyku (anglický jazyk) a (3) v zahraničí (Slovensko) zvládnuť výzvu pri príprave na praktickú časť ich štúdia – konverzácia s pacientom v Slovenskom jazyku.Zámerom je poskytnúť študentom krok za krokom najfrekventovanejšie slovné spojenia a výrazy potrebné pri komunikácii s pacientom. Lekcie sa zameriavajú hlavne na slovnú zásobu týkajúcu sa častí ľudského tela a na základné symptómy a príznaky chorôb.Dôraz je kladený na krátke dialógy medzi lekárom a pacientom. Pri precvičovaní dialógov sú študenti vedení k nácviku komunikácie so zreteľom na porozumenie, bez prípadných obáv o gramatickú správnosť. Gramatické javy sú predstavované postupne, cez jednoduché  pomôcky – „tipy“.V prípade potreby si môžu študenti nájsť a doplniť si „chýbajúce časti gramatiky“ prostredníctvom odkazov na odporúčanú literatúru. Cieľom tejto knihy je uľahčiť a zefektívniť celý proces štúdia/osvojenia si (lekárskej) slovenčiny.

H.Mičková - V.Habalová - J.Židzik - E.Slabá

Mária Zamboriová - Lucia Dimunová - Valéria Parová 

Mária Sováriová Soósová - Gabriela Štefková

Healthcare professionals are expected to provide quality, evidence-based health care with an emphasis
on patient safety. Nursing Care - Clinica/ Procedures II is a guidebook of practical procedures for
nurses and medical students and practitioners working in health care setting. This book reflects
changes in nursing, professional, and national guidelines. It should help you to achieve essential
knowledge, abilities and skills in area of vital signs monitoring, reduced mobility care, nutrition and
hydration care, medicine management, blood transfusion management, blood sampling,and care of elimination. To provide clear structure, each topic begins with brief introduction, continues with description of indications, contraindications and possible complications of procedure, necessary equipment and step-by-step procedure implementation supported by illustrations and additional information. 

Od zdravotníckych pracovníkov sa očakáva poskytovanie kvalitnej zdravotnej starostlivosti založenej na dôkazoch s dôrazom na bezpečnosť pacientov. Ošetrovateľská starostlivosť - Klinické postupy ll je príručka praktických postupov pre sestry a študentov medicíny a lekárov pracujúcich v zdravotníckom prostredí. Táto učebnica odráža zmeny v ošetrovateľských, odborných a národných smerniciach.Učebnica má za cieľ pomôcť dosiahnuť základné vedomosti, schopnosti a zručnosti v oblasti monitorovania vitálnych funkcií, starostlivosti o zníženú pohyblivosť, starostlivosti o výživu a
hydratáciu, manažment aplikácie liekov, manažment podávania transfúzie krvi, odberu krvi a
starostlivosti o elimináciu. Aby sa zabezpečila jasná štruktúra, každá téma sa začína krátkym úvodom, pokračuje opisom indikácií, kontraindikácií a možných komplikácií postupu, potrebného vybavenia a zavedenia postupu krok za krokom, podporeného ilustráciami a ďalšími informáciami. 

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Terézia Kisková - Stanislav Matéffy - Františka Horváthová

The laboratory rat (Rattus norvegicus) is one of the most commonly used experimental animals. It serves as a model organism for analyzing numerous biological processes and pathological mechanisms, such as cardiovascular diseases, metabolic disorders (e.g., lipid metabolism, diabetes mellitus), neurological and neuropsychiatric conditions (e.g., stroke, epilepsy, or Alzheimer's disease), neurobehavioral research, autoimmune diseases (e.g., arthritis), cancer, and renal diseases. It offers many unique advantages for modeling human diseases, testing drugs and natural substances, and studying responses to environmental factors. The size of the laboratory rat, compared to the mouse, creates ideal conditions for physiological manipulations. Additionally, rats are used in clinical toxicology to test chemical substances (Hedrich, 2000).

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Kvetoslava Rimarová a kol.

Učebnica poskytuje komplexný a interdisciplinárny pohľad na problematiku humánnej výživy v kontexte verejného zdravotníctva, hygieny výživy a prevencie ochorení. Je koncipovaná ako základný aj rozširujúci študijný materiál pre študentov zdravotníckych, biomedicínskych a verejno-zdravotníckych odborov, ako aj pre odborníkov pôsobiacich v oblasti výživy, hygieny, potravinárstva a zdravotnej politiky. Publikácia systematicky pokrýva všetky kľúčové oblasti výživy človeka – od základných zložiek potravy (bielkoviny, sacharidy, tuky, vitamíny, minerálne látky), ich biologickej a energetickej hodnoty, cez odporúčané výživové dávky a tvorbu racionálneho jedálnička, až po hodnotenie nutričného stavu populácie. Osobitná pozornosť je venovaná antioxidantom, probiotikám a funkčným potravinám, ktoré predstavujú moderný a dynamicky sa rozvíjajúci segment výživovej vedy.

Učebnica reflektuje aktuálne trendy v stravovaní vrátane alternatívnych spôsobov výživy, prerušovaného pôstu, vysokoproteínových diét a konzumácie spracovaných a ultraprocesovaných potravín, pričom ich hodnotí z hľadiska vedeckých dôkazov, zdravotných prínosov aj rizík. Dôležitou súčasťou je problematika cudzorodých látok v potravinách, potravinárskych aditív a legislatívnych rámcov ich používania, ako aj význam pitnej vody, jej kvalita, úprava a zdravotné riziká spojené s kontamináciou. Publikácia sa venuje aj špecifickým oblastiam, ako sú alimentárne nákazy, výživa v jednotlivých vývinových obdobiach detí, nemocničné stravovanie a diétne systémy.

Praktickú hodnotu učebnice zvyšuje zaradenie metodicky spracovanej praktickej časti zameranej na mikrobiologické hodnotenie pokrmov rýchleho občerstvenia, založenej na reálnych dátach regionálnych úradov verejného zdravotníctva. Text je spracovaný prehľadne, s využitím tabuliek, obrázkov a aktuálnej odbornej literatúry, čo umožňuje čitateľovi nielen osvojenie teoretických poznatkov, ale aj ich aplikáciu v praxi. Učebnica predstavuje ucelený, moderný a vedecky podložený zdroj poznatkov o výžive ako jednom zo základných determinantov zdravia populácie.

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Silvia Danková - Valéria Parová - Gabriela Štefková - Libuša Tirpáková

This university textbook is intended for students of the field of nursing and brings closer the issues in selected clinical fields of nursing, namely dermatovenerology, ophthalmology, otorhinolaryngology and dentistry.

It focuses on the characterization, management of care, reporting and dispensing of specific diseases and nursing care of selected diseases in these fields. It provides important information on the implementation of specific investigative methods and nursing activities that reflect the latest knowledge of the profession, professional guidelines and evidence-based practice.

The authors used relevant sources of domestic and foreign literature as well as electronic sources, which are listed at the end of individual chapters, when processing individual topics. The aim of the authors was to create a university textbook that would help nursing students to orientate themselves in the mentioned clinical fields, or could also be beneficial for nurses in practice.

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Monika Halánová-Leonard Siegfried

Although chronic non-communicable diseases currently dominate overall morbidity and mortality in developed countries, epidemics of infectious diseases, especially those caused by new or emerging pathogens, occur more frequently and spread faster and further in new territories. The starting factors of this threat are mainly ecological and climatic changes and changes in human demography and behaviour. The growing resistance to ATB is also very serious, as a result of which there is a significant increase in the incidence of infectious diseases and their spread to new geographical locations. Current problems of epidemiology and microbiology in research and clinical practice are mainly focused on rapid detection and subsequent response to diagnosed diseases. The correct diagnosis of an infectious disease is the result of a clinical picture, knowledge of the current epidemiological situation and laboratory confirmation of the etiological agent. The identification of microorganisms allows us to establish the correct definitive diagnosis and subsequent targeted therapy, but also to start immediately with appropriate anti-epidemic measures to control the spread of the infectious agent.

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Adriana Boleková (ed.)

Proceedings of Scientific Works

The Košice Morphological Day is an annual May meeting of morphologists, primarily attended by Košice morphological workplaces. On this occasion, a collection of scientific works is regularly published.

This year's collection was published on the occasion of the 23rd Košice Morphological Day, which did not take place due to the poor epidemiological situation.

In the collection, the authors present the results of their scientific-research and pedagogical activities, which are in the form of theoretical overview studies and research works.

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Ingrid Hodorová - Květuše Lovásová

Publikácia je pokračovaním už vydanej vysokoškolskej učebnice "Ultrasonografická anatómia 1" a dopĺňa ďalšiu medzeru na medicínskom literárnom trhu, týkajúcu sa ultrasonografického pohľadu na periférne nervy a cievy končatín a krku.

Peter Berek 

S vývojom endovaskulárnej chirurgie dochádza postupne k rozvoju stentingu ACI. Minimálne invazívny prístup spravil túto metodiku vhodnú pre pacientov s vážnymi konkomitatnými kardiálnymi alebo pľúcnymi ochoreniami. Ďalšou výhodou v porovnaní s chirurgickou liečbou bol lepší prístup k ACI u pacientov po rádioterapii, po predchádzajúcich operáciách na krku, ale aj u pacientov so stenózami blízko lebečnej bázy. Porovnanie CEA vs CAS je zaujímavou a diskutabilnou témou mnohých štúdií. Avšak, aj napriek celosvetovému mohutnému rozvoju endovaskulárnej liečby karotická endarterektómia ostáva zlatým štandardom liečby stenózy ACI u symptomatických aj asymptomatických pacientov.

V tejto monografii by sme radi akcentovali a systematizovali problematiku chirurgickej prevencie CMP z pohľadu cievneho chirurga.