CYTOCHROME P-450: genetic and population aspects

E-book

Jaroslava Kopčáková

Download the e-book for free (pdf)

František Sabola kol.

Although we are not really sure if “Love is coming from the Heart” and nor we know where “the Residence of Soul” is, we are still overwhelmed by its unprecedented effort to keep us alive. Our lives are nowadays fulfilled with enormous chances to satisfy our needs and wishes. Hand in hand is changing our way of life, the intake of calories is growing and the amount of physical activity decreasing. We live longer and maybe happier but our hearts
and vessels are like mirrors showing us how we live. Diseases of the Heart and vessels have become the number one cause of death in highly developed countries including our homeland.
Prevention of cardiovascular diseases has become and an important social and health care system issue. The knowledge requirement of basic principles of cardiology and heart surgery is increasing. Without an understanding of basic principles a good clinical practice is hardly possible.
Together with my Colleagues of Heart surgery department of VÚSCH and LF UPJŠ we prepared this short overview of basic knowledge about surgery of the human heart. We hope that reading it will be more an adventure than a painful journey. If you find some answers to your unanswered questions our effort was not a waste of time.

Authors

E-book

Zuzana Kozelová

Vysokoškolský učebný text Chlopňové chyby je prvou slovenskou publikáciou, ktorá sa venuje využitiu simulátorovej medicíny vo výučbe auskultácie srdca. Cieľom publikácie bolo skvalitnenie štúdia vnútorného lekárstva využitím kardiologického simulátora, ktorým disponuje Centrum simulátorovej a virtuálnej medicíny (CSVM) na Lekárskej fakulte UPJŠ. Výučbový materiál môže poslúžiť nielen ako príprava k praktickým cvičeniam so simulátorom Cardiology Patient Simulator „K“ ver 2 (Kyoto Kagaku), ale aj ako užitočná pomôcka pre študentov počas praktických cvičení pri lôžku pacienta. Študenti v publikácii nájdu okrem detailného opisu auskultačných nálezov na jednotlivých chlopniach aj podrobne vysvetlenú ich klinickú manifestáciu u pacienta pri fyzikálnom vyšetrení. Samozrejmou súčasťou sú EKG a echokardiografické nálezy a v neposlednom rade aj možnosť manažmentu jednotlivých chlopňových chýb podľa najnovších odporúčaní Európskej kardiologickej spoločnosti. Využitie publikácie je pre študentov medicíny od internej propedeutiky (3. ročník) až po záverečné štátnicové skúšky.

Náhľad v pdf

Knihu si môžete kúpiť v tlačenej verzii na tomtoodkaze

E-book

Adriana Boleková (ed.)

Proceedings of Scientific Works

The Košice Morphological Day is an annual May meeting of morphologists, primarily attended by Košice morphological workplaces. On this occasion, a collection of scientific works is regularly published.

This year's collection was published on the occasion of the 23rd Košice Morphological Day, which did not take place due to the poor epidemiological situation.

In the collection, the authors present the results of their scientific-research and pedagogical activities, which are in the form of theoretical overview studies and research works.

Download the e-book for free  (pdf)

Ingrid Hodorová a kolektív

                Vysokoškolská učebnica „Ultrasonografická anatómia 1“ je určená predovšetkým študentom lekárskych fakúlt. Publikácia dopĺňa medzeru na medicínskom literárnom trhu, na ktorom takýto druh literatúry doteraz absentuje. V učebnici sa čitateľ oboznámi s koreláciou anatomického a ultrasonografického obrazu orgánov a štruktúr za fyziologického stavu. Táto korelácia poukazuje na úzke prepojenie teoretického predmetu anatómia s klinickou praxou s ultrasonografickým vyšetrením, ktoré je dnes neoddeliteľnou súčasťou základných vyšetrovacích metód v mnohých medicínskych odboroch.

                Učebnica pozostáva z anatomickej časti, ktorá sa venuje základnému anatomickému popisu jednotlivých orgánov brucha a panvy. Nosnou časťou učebnice je sonografická časť, ktorá popisuje a charakterizuje jednotlivé ultrasonografické snímky. Čitateľ môže priamo porovnať vzhľad a prípadné rozdiely orgánov a štruktúr získaných dvomi úplne odlišnými zobrazeniami.

                Veríme, že nová vysokoškolská učebnica splní očakávania študentov, ako aj všetkých tých, pre ktorých je oblasť ultrasonografického zobrazenia z pohľadu anatóma predmetom záujmu – bude tak prospešná nielen pre anatómov, ale aj pre začínajúcich sonografistov.

Alžbeta Blichárová a kolektív

“Pathology Part 1 (winter semester) - Practical lessons for students of general medicine” represents the first half of the university textbook designed for the pregradual study of pathology. The textbook complements the lectures of pathology and serves as a source of information for students of general medicine, that are preparing for the practical as well as the final oral examination.

In this part of the “Pathology” series, seventy selected histopathological slides are presented. Each selected slide is provided with general information in relation to etiology and pathogenesis of the disease, as well as with corresponding morphological features, including the gross appearance and the most important histopathological characteristics. The textbook summarizes the basic concepts of general pathology that are necessary to master the broad field of systemic pathology in the second semester.

Keywords: general pathology – histopathological slides – general medicine – gross appearance – microscopic image

E-book

Iveta Domoráková et al.

The e-learning textbook is available at: https://portal.lf.upjs.sk. The textbook contains 11 chapters focusing on the microscopic anatomy of the head and neck region, with an emphasis on the oral and nasal cavities, skull bones and their development, and the detailed microscopic structure of teeth and their development. One chapter is dedicated to dentition from the perspective of the clinical significance of understanding tooth structure and development. The textbook includes chapters on the microscopic anatomy of organs that are functionally important for the head region, such as the vascular, lymphatic, endocrine, and nervous systems. The textbook is linked to an atlas, has a total of 490 pages, and features 300 original microphotographs using common histological stains, histochemical, immunohistochemical, and impregnation methods.

The textbook was created with the support of the KEGA project 019UPJŠ-4/2016.

Download it from the Mefanet portal (pdf)

E-book

Martina Šemeláková (ed.)

Proceedings contain abstracts from participants of the scientific conference with international participation under the name: Student scientific international conference GenICa”, supported by the project "Bilateral relations and common knowledge between Slovakia and Iceland research at Universities on the topic "Genomic instability and cancer "GenICa", funded under the EEA and Norwegian 2014-2021 Financial Mechanism Programme (FBR02, bilateral initiatives under the Fund for Bilateral Relations at national level co-financed by EEA and Norwegian Financial Mechanism 2014-2021) which took place on 19 - 21 June 2024 in the premises of Hotel Sorea Trigan, Štrbské Pleso, Slovakia.

Download e-book for free (pdf)

E-book

Tatiana Kimáková

The scientific monograph focuses on health determinants, healthy nutrition, its fundamental components, the consequences of unhealthy nutrition, and alternative dietary trends. The work also includes research targeting selected lifestyle factors among university students, particularly nutrition, eating habits, and physical activity.

This scientific monograph is suitable for the scientific community, students of medical and natural sciences, and public health professionals at all three levels of higher education. It is equally valuable for members of the informed general public interested in the subject.

Download the e-book for free (pdf)

E-book

Martina Čižmáriková - Peter Takáč 

It is known that pharmacology is a rapidly evolving medical field, with information about drug forms and their routes of administration constantly changing. In addition to the emergence of new drug forms, new trends are also observed in the routes of administration suitable for delivering drugs. Despite being significant factors influencing the efficacy and safety of pharmacotherapy – an indispensable component of comprehensive patient care – to our knowledge, there has been a lack of comprehensive and detailed textual material focused on this issue on the market. This fact is related to the broader scope of the professional text we are presenting, as rare drug forms or less commonly used routes of administration are only marginally mentioned or not mentioned at all in available pharmacology textbooks.

Our main goal was therefore to provide sufficient information about existing drug forms, their routes of administration, as well as their methods of delivery, which should serve to enhance the quality of pharmacotherapy in the context of so-called "tailored treatment," whose main effort is to individualize treatment for a specific patient. Although the work focuses on drug application methods, a detailed description of the technical implementation of algorithms and other related procedures is the subject of interest for other fields (nursing, surgical propaedeutics, etc.). Overall, it is a supplementary educational text provided in electronic form, which is extremely popular in today's modern informatized era. Thanks to this, the work can be used at any time at home or in a school environment, comprehensively or progressively, partially. We have also tried to enhance its quality by appropriate content organization, inclusion of practical experiences, as well as the inclusion of colorful images or photographs, overview tables, and appendices.

The textbook is supplemented by test quizzes serving to verify acquired selected knowledge, which are published on the website of the Department of Pharmacology at the Medical Faculty of UPJŠ in Košice (under "Teaching" → "Taught subjects"), and which will be continuously supplemented and updated (http://www.lf.upjs.sk/farmakologia/TEST%201.htm; http://www.lf.upjs.sk/farmakologia/TEST%202.htm).

Although the work is primarily intended for medical students, or students of pharmacy and other healthcare fields, we firmly believe that enriching information will be found in it by beginning graduates of these fields, as well as their teachers.

Download the e-book for free (pdf)

E-book

Lucia Dimunová - Jana Michalková - Gabriela Štefková - Mária Zamboriová

Following innovative trends in university education, this academic textbook offers guidance to update and make the educational process more attractive for all healthcare professions. It applies critical thinking and strategic method of concept mapping in teaching, which are suitable tools for the facilitator and the educant to achieve the desired goal. Critical thinking is an essential academic skill upon which other knowledge and intellectual virtues can be built. It is also an essential equipment for every graduate of the healthcare profession.

The textbook is complemented by a chapter focusing on methods for structural and formative assessment of learning outcomes. The publication is also enriched with sample digital concept maps of which cognitive content can be edited and graphically modified.

The aim of this academic textbook is to present a way of acquiring knowledge through critical thinking using concept mapping as a method, with the final goal of implementing the acquired knowledge into everyday practice.

Download e-book for free (pdf)

E-book

Ivana Hockicková-Ondrej Zahornacký

The textbook „Selected chapters in Infectology“ is a comprehensive study material about selected infectious diseases for students of medicine as well as other healthcare professions. It is primarily intended for students of general and dental medicine. It is the first textbook of its kind, aiming to provide students with comprehensive information about different types of infectious diseases, including their causes, typical symptoms, diagnostics, treatment and prevention. It is divided into a total of 18 chapters. The textbook is written in accordance with the latest knowledge about infectious diseases and serves as the foundation for success in the Infectology subject.

Download e-book for free (pdf)

E-book

Zuzana Dankulincová a kol.

The scientific monograph is the output of the Care4Youth project, which aimed to map the current system of care for adolescents with emotional and behavioral problems (EBP) in Slovakia. It captures what the care system is and what its possible shortcomings are from the perspective of all those affected (adolescents with problems, their parents, care providers and other institutions involved).

It also looks at the trajectory of adolescents with EBP in the care system, i.e. when and how adolescents with problems enter and leave the care system, or pass from one type of care to another and what impact different trajectories have on them.

Last but not least, the aim of the monograph was to provide expert information on what are the risk and protective factors that will affect their success in the care system or, conversely, that threaten them. All this in order to support the proposal for improvements in the care system that would benefit all stakeholders.

Download the e-book for free  (pdf)

E-book

Vladimíra Timková a kol.

Slovakia has one of the highest mortality rates from preventable and treatable causes. The latest data also shows that within the EU, we have the highest mortality rate from cancer. A person's health is influenced by a combination of genetics, different life circumstances, and personal decisions. While we do not have control over all of these factors, proper eating habits, regular physical activity, and quality sleep can significantly contribute to preventing health problems and chronic diseases. However, many people face barriers such as financial constraints, work overload, or a lack of reliable information and knowledge. In Slovakia, almost half of the population cannot afford to purchase nutritious food, which makes the situation even more difficult. Therefore, we have prepared a practical guide with simple, affordable, and time-efficient recommendations aimed at improving health and quality of life. The publication provides an overview of the latest research and expert recommendations related to healthy eating, sleep hygiene, physical activity, mental health improvement, building resilience and healthy relationships, and also includes important advice on how to increase motivation for health behaviour change.

Download the e-book for free (pdf)

E-book

Terézia Kisková - Stanislav Matéffy - Františka Horváthová

The laboratory rat (Rattus norvegicus) is one of the most commonly used experimental animals. It serves as a model organism for analyzing numerous biological processes and pathological mechanisms, such as cardiovascular diseases, metabolic disorders (e.g., lipid metabolism, diabetes mellitus), neurological and neuropsychiatric conditions (e.g., stroke, epilepsy, or Alzheimer's disease), neurobehavioral research, autoimmune diseases (e.g., arthritis), cancer, and renal diseases. It offers many unique advantages for modeling human diseases, testing drugs and natural substances, and studying responses to environmental factors. The size of the laboratory rat, compared to the mouse, creates ideal conditions for physiological manipulations. Additionally, rats are used in clinical toxicology to test chemical substances (Hedrich, 2000).

Download the e-book for free (pdf)

E-publication

Eva Slabá-Helena Mičková-Jozef Židzik-Lucia Klimčáková-Janka Vašková

Teaching texts „Practical Lessons in Medical biology“ provide the theoretical foundations of microscopy, various microscopic techniques and preparation of microscopic slides in an understandable form. The chapters of the teaching texts contain model questions and tasks from cytology, molecular biology and genetics enabling students to acquire new knowledge from individual thematic areas and provide instructions for the implementation of tasks during laboratory lessons in medical biology. Teaching texts are primarily intended for the practical lessons in the subjects Biology 1 and Biology 2 for foreign students of the first year of General Medicine and the subjects Medical Biology and Genetics and Regenerative Medicine for foreign students of the first and second year of Dental Medicine at P. J. Šafárik University in Košice – Faculty of Medicine.

Download the e-book for free (pdf)