CYTOCHROME P-450: genetic and population aspects

E-book

Erik Dosedla

A uterine scar is currently a significant medical problem. Uterine scars most commonly occur after a Cesarean section, which is one of the most frequent laparotomic surgeries (Yazicioglu et al., 2006). The frequency of Cesarean sections increased between 1990 and 2014 in the USA from 21.2% to 32.2% (Hamilton et al., 2015), in Great Britain from 12% to 26.2% (NHS Maternity Statistics - England, 2013-14: Summary Report, 2015), and in the Slovak Republic from 8.7% to 31% (Národné centrum zdravotníckych informácii, 2016).

After a Cesarean section (CS), there is a risk of abnormal healing of the uterotomic wound, which can result in the development of certain pathological conditions in consecutive pregnancies (uterine rupture, ectopic pregnancy in the Cesarean scar, placental disorders) (Seow et al., 2004; Oyelese and Smulian, 2006; Fitzpatrick et al., 2012). In addition, a defect in the Cesarean scar is associated with chronic dysmenorrhea, chronic pelvic pain, infertility, and postmenstrual spotting (Wang et al., 2009; Bij de Vaate et al., 2011).

Ultrasound is a valuable examination method in the diagnostic and therapeutic management of these pathological conditions.

Download e-book for free (pdf)

E-book

Tatiana Kimáková - Vladimír Pavlík

The scientific monograph focuses on the characteristics of free radicals, reactive oxygen and nitrogen species, oxidative stress, and its impact on various diseases. A significant portion is dedicated to antioxidants, their classification based on multiple criteria, the characteristics of selected antioxidants in terms of their functions, manifestations of their deficiency and excess, and the overall antioxidant capacity of the body.

A special section is devoted to enzyme-based antioxidants, natural sources of antioxidants in the form of vitamins, trace elements, flavonoids, polyphenols, and coenzyme Q10. To provide a clearer understanding of antioxidants and their influence on population health, the monograph presents results from a research project included in the program "Research Support for Enhancing the Defense Capabilities of the Czech Republic in NATO Structures."

The research was conducted between 2010 and 2012 as part of preventive rehabilitation programs for professional soldiers with a sports component. The study involved 218 professional soldiers, including 180 men and 38 women, with an average age of 33.3 years. The current health status and dietary habits of the soldiers were assessed using questionnaires.

The study described the saturation of the observed group with antioxidant vitamins and statistically evaluated the relationship between their levels and the risk indicators for the development of cardiovascular diseases. Individual analyses were performed using the Reflotron device calibrated with Reflotron Precinorm control serum. Following blood collection, all participants underwent anthropometric examinations (body weight, height, waist circumference), blood pressure measurements, heart rate monitoring, and physical fitness assessments through simple functional tests.

This scientific monograph is suitable for the scientific community, students of medical, veterinary, and natural sciences, as well as public health students at all levels of university education. It is also intended for informed members of the public.

Authors

Download the e-book for free (pdf)

Marián Sabol - Helga Kostelná - Leonard Siegfried

Cieľom učebných textov je poskytnúť študentom medicíny a príbuzných odborov   poznatky o základných imunologických metódach, ktoré sa využívajú v klinickej praxi. V učebných textoch sú zahrnuté metódy na vyšetrenie fagocytózy, komplementu, imunoglobulínov, autoprotilátok,  HLA molekúl a T lymfocytov.  Súčasťou textov sú aj  postupy pre izoláciu a stanovenie počtu vybraných  typov buniek imunitného systému. Kombinácia klasických  metód (rozetové testy, fluorescenčná mikroskopia) a moderných metód   (napríklad prietoková cytometria a  ELISPOT) umožňuje orientáciu v základných laboratórnych metódach imunológie.

E-book

Andrea Madarasová Gecková - Daniela Husárová   a kol.

National Report on the Health and Health-Related Behaviour of 11-, 13-, and 15-Year-Old Schoolchildren Based on the Survey Conducted in 2021/2022 within the International Project “Health Behaviour in School-aged Children” (HBSC)

For several years, this study has provided us with key insights for a better understanding of the health-related behaviour of our young people. It examines a range of health-related topics such as sleep, mental well-being, nutritional behaviour, and physical activity. Important areas of research also include school and social relationships within it, family and family background, as well as peer relationships.

The findings deepen our understanding of the mechanisms influencing differences and changes in young people’s health and risk behaviours. They are crucial for the development of effective health promotion programmes and health-related behavioural interventions, educational programmes in this field, and for monitoring their effectiveness—not only at the national but also at the international level. The knowledge gained is important for a better understanding of the needs of schoolchildren and for adapting services and systemic support so that these needs are taken into account to the greatest possible extent in today’s rapidly changing world. The study can help us understand the impact of the COVID-19 pandemic on the quality of both mental and physical health.

The pandemic and the related epidemiological and hygiene measures aimed at limiting the spread of the virus have meant significant restrictions in the daily lives of people of all ages—including children and adolescents. The standard educational process, social contact with peers, extracurricular activities, and other interests both in and out of school were severely disrupted, which had a significant impact on the experiences of schoolchildren.

Download the e-book for free (pdf)

E-book

Pavol Jarčuška - Pavol Kristian - Ivan Schréter (eds.)

The abstract almanac was issued at the occasion of XXII. Slovak – Czech congress on infectoius diseases held in Jasná.

Overall it contains 70 reports that cover current issues in infectology. Contributions are focused on patients with infections caused by multidrug resistant organisms, HIV infected patients, patients with hepatitis and infections in immunocompromised patients.

Thers is a special section dedicated to new aspects in nursing care.

Download the e-book for free (pdf)

E-book

Silvia Danková - Valéria Parová - Gabriela Štefková - Libuša Tirpáková

This university textbook is intended for students of the field of nursing and brings closer the issues in selected clinical fields of nursing, namely dermatovenerology, ophthalmology, otorhinolaryngology and dentistry.

It focuses on the characterization, management of care, reporting and dispensing of specific diseases and nursing care of selected diseases in these fields. It provides important information on the implementation of specific investigative methods and nursing activities that reflect the latest knowledge of the profession, professional guidelines and evidence-based practice.

The authors used relevant sources of domestic and foreign literature as well as electronic sources, which are listed at the end of individual chapters, when processing individual topics. The aim of the authors was to create a university textbook that would help nursing students to orientate themselves in the mentioned clinical fields, or could also be beneficial for nurses in practice.

Download e-book for free (pdf)

E-book

Ján Mojžiš - Ladislav Mirossay -Andrej Miroššay (eds.)

This long-standing scientific conference continues its tradition of fostering collaboration, sharing knowledge, and supporting progress in the fields of pharmacology, pharmacy, toxicology, and biomedical sciences. The 2025 meeting brings together distinguished researchers, clinicians, educators, and students from the Czech Republic, Slovakia, and beyond, united by a common goal—to advance our understanding of pharmacological science and improve human health.

Download the e-book for free (pdf)

E-book

Zuzana Kozelová

Vysokoškolský učebný text Chlopňové chyby je prvou slovenskou publikáciou, ktorá sa venuje využitiu simulátorovej medicíny vo výučbe auskultácie srdca. Cieľom publikácie bolo skvalitnenie štúdia vnútorného lekárstva využitím kardiologického simulátora, ktorým disponuje Centrum simulátorovej a virtuálnej medicíny (CSVM) na Lekárskej fakulte UPJŠ. Výučbový materiál môže poslúžiť nielen ako príprava k praktickým cvičeniam so simulátorom Cardiology Patient Simulator „K“ ver 2 (Kyoto Kagaku), ale aj ako užitočná pomôcka pre študentov počas praktických cvičení pri lôžku pacienta. Študenti v publikácii nájdu okrem detailného opisu auskultačných nálezov na jednotlivých chlopniach aj podrobne vysvetlenú ich klinickú manifestáciu u pacienta pri fyzikálnom vyšetrení. Samozrejmou súčasťou sú EKG a echokardiografické nálezy a v neposlednom rade aj možnosť manažmentu jednotlivých chlopňových chýb podľa najnovších odporúčaní Európskej kardiologickej spoločnosti. Využitie publikácie je pre študentov medicíny od internej propedeutiky (3. ročník) až po záverečné štátnicové skúšky.

Náhľad v pdf

Knihu si môžete kúpiť v tlačenej verzii na tomtoodkaze

Mária Pallayová - Štefan Kujaník

The “Textbook of Practical Physiology, Part I - Cardiovascular Physiology” by Mária Pallayová and Štefan Kujaník is a practical textbook of Human Physiology intended for English speaking medical students from general medicine and dentistry curricula.

The textbook covers basic principles in cardiovascular physiology and methods of the cardiovascular examination. Adequate knowledge of the cardiovascular physiology is important for the understanding of cardiovascular system function, as well as for the diagnosis and proper treatment of cardiovascular and other diseases. The practical tasks are constructed to facilitate knowledge acquisition and encourage students to develop practical skills, for instance the ability to follow experimental protocols, to work as part of a team, and to interpret data.

The textbook is written in English and comprises 91 pages in B5 format, grouped into twelve chapters. Each chapter is divided into six sections (Introduction, Principle, Importance, Materials, Procedure, and Protocol) to facilitate students’ understanding of the topics and assist them with preparation of the laboratory reports. The text is accompanied by explanatory figures, graphs, and tables that contribute to the learning experience.

Authors

Darina Kluchová a kol. 

An illustrated text for dental students

Marek Stupák et al.

Medical Chemistry presents an overview of the most important topics of general, organic and bioinorganic chemistry for students of General and Dental Medicine study programs. Its aim is to provide a theoretical basis for the study of the subject Medical Chemistry and for understanding processes and chemical reactions which are taking place in the human body.

Each topic directly links chemical principles to the processes in living organisms and thus can help the students to clearly see the application of the presented information. Therefore, it also provides a good starting point for further study of Medical Biochemistry, for which the knowledge of these principles is necessary.

Download e-book for free (pdf)

E-book

Mária Sováriová Soósová a kol.

The proposed university textbook provides knowledge in the field of nursing in internal medicine. It is intended primarily for students of the nursing program, but also for nurses working in this specialization. The textbook builds on the previous two parts: Nursing Process in Internal Medicine I (Sováriová Soósová, 2006) and Nursing Process in Internal Medicine II (Suchanová, 2007). It is divided into four chapters, focusing on disorders of water and electrolyte balance and acid-base equilibrium, kidney and urinary tract diseases, endocrine system diseases, and musculoskeletal disorders.

Each chapter is similarly structured, beginning with diagnostic methods commonly used in the respective area. Subsequent subchapters address nursing care for selected diseases of specific bodily systems. Each subchapter consists of a clinical introduction (characteristics of the disease, its etiology, clinical presentation, diagnosis, and treatment) and nursing care for the given disease. This includes assessment, formulation of nursing diagnoses, and planning nursing care (setting goals, outcome criteria, and planning possible interventions).

The textbook serves as a model framework and algorithm for managing nursing care using the nursing process method.

Download the e-book for free (pdf)

E-book

Ahmad Gharaibeh - Marek Lacko

Authors describe the clinical and paraclinical examination methods necessary for the diagnosis and treatment of orthopedic diseases in both children and adults.

The examination methods are categorized based on individual anatomical locations. A valuable chapter discusses joint aspirations, detailing their indications, techniques for performing them, and potential complications. The chapter showcasing patient documentation for students serves as a significant aid for practical exams before the state final examination in surgery.

This work appropriately complements the available educational literature required for international undergraduate students in general medicine, as well as for physicians in specialized training in orthopedics and related fields.

Download e-book for free (pdf)

Jozef Radoňak a kol.

Skriptá chirurgická propedeutika predstavujú učebné texty prinášajúce pohl'ad do histórie chirurgie cez všeobecne platné princípy chirurgie, moderné diagnostické a terapeutické metó­dy. Patričná pozornost' sa venuje základom chirurgickej onkológie, úrazovej chirurgie, anesteziológie a resuscitácie ako aj liečbe krvácania, infekcie, šoku či transplantáciám. Súčas­ťou textu sú aj kapitoly z vojnovej chirurgie.

Květuše Lovásová a kol. 

Despite the wide range of high quality textbooks offered on the Slovak market there is no publication with colorful pictures and schemes that can serve as an principal tool for practical and theoretical teaching of neuroanatomy for future psychologists in non-medical academic programmes of Arts and Science Faculties. Following new trends in methods of teaching, it is necessary to pay more attention to quality, depth, and effectiveness of education.

Such kind of illustrated textbook with the interesting graphic design should connect this important morphological subject and clinical medicine to understand the nervous system in the clinical context. This publication was created by using of original, new detailed pictures, and graphic schemes and was supplemented with a short clinical notes. It will be very helpfull to understand the details of neuroanatomical structures and brain regions.

We hope that originality and details of this book will find its application in studies of neuroanatomy for psychologists. 

H.Mičková - V.Habalová - J.Židzik - E.Slabá