Ortuť v životnom prostredí ako rizikový faktor zdravia

Mária Frankovičová - Jana Kaťuchová

Dear readers and students,

The book “Surgery for Medical Students“ is a textbook intended to be used by those studying at medical faculties and in other healthcare fields. In this textbook, the authors, encompassing all surgical specialties, have tried to provide the reader with a holistic context of the study material intended to be used in preparation for the state exam from surgery. I thank all the co-authors for their willingness and cooperation. To the students I hope you have a pleasant time reading and studying the book.

Prof. MUDr. Mária Frankovičová, PhD

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Ján Mojžiš - Ladislav Mirossay -Andrej Miroššay (eds.)

This long-standing scientific conference continues its tradition of fostering collaboration, sharing knowledge, and supporting progress in the fields of pharmacology, pharmacy, toxicology, and biomedical sciences. The 2025 meeting brings together distinguished researchers, clinicians, educators, and students from the Czech Republic, Slovakia, and beyond, united by a common goal—to advance our understanding of pharmacological science and improve human health.

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Lucia Dimunová - Jana Michalková - Gabriela Štefková - Mária Zamboriová

Following innovative trends in university education, this academic textbook offers guidance to update and make the educational process more attractive for all healthcare professions. It applies critical thinking and strategic method of concept mapping in teaching, which are suitable tools for the facilitator and the educant to achieve the desired goal. Critical thinking is an essential academic skill upon which other knowledge and intellectual virtues can be built. It is also an essential equipment for every graduate of the healthcare profession.

The textbook is complemented by a chapter focusing on methods for structural and formative assessment of learning outcomes. The publication is also enriched with sample digital concept maps of which cognitive content can be edited and graphically modified.

The aim of this academic textbook is to present a way of acquiring knowledge through critical thinking using concept mapping as a method, with the final goal of implementing the acquired knowledge into everyday practice.

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Vladimíra Tomečková

Nature, as well as the human body, contains an abundant quantity of organic molecules. This textbook describes selected oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds of their reactions, which are important in the human body or are found in pharmaceutical active substances, poisons, foodstuffs and heat-treated food. The last part of the textbook describes the isomerism of organic compounds, which enables dynamic changes in the structure of molecules that have different properties. Nature is filled with different plants and animals and is the first laboratory to produce bioactive organic natural compounds. These compounds are compatible with human cells and are applicable as therapeutic medicine. There is an effort to reproduce natural molecules in chemical laboratories, but they cannot be as perfect as the natural ones. Synthetic molecules can serve as a model for multiple studies, but there still does not exist a magic panacea pill or a perfect copy of nature, for the treatment of various diseases. Knowledge about the regenerative and toxic effect of medicinal substances in dependence on their structure (type and number of substituents) is very important for the understanding of their role in modulation of health and disease in dependence on their concentration. Compounds can be used daily only in recommended doses (higher doses can be toxic), but still will not replace a healthy diet. People need a varied diet to be healthy, in which are all necessary nutrients, what Hippocrates demonstrated long ago “Let food be the medicine, and let medicine be the food.” This book is written for students who select bioorganic chemistry subject during the study of general medicine or dentistry as well as for motivated students who would like to practice their knowledge and wish to improve in this subject and for students who would like to learn simplified basic organic reactions with their future application in biochemistry. Learn the simple models mainly through creative simple instruction by using different colours, by repetition, practice by drawing of formulas by hand (at least three times) and memorization of common names of compounds and their reactions which have application in biochemistry. Thus, establishing simple educational methods how to distinguish organic molecules according to the colours of a functional group can promote universal learning for all students who thought that chemistry is a difficult subject, but hopefully they change their opinion after study of this book.

Keywords: organic molecules, oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds, chemical reactions, isomerism of organic compounds

Gabriel Koľvek

Tento učebný text je zameraný na najčastejšie ochorenia obličiek detského veku. Venuje sa vybraným vrodeným (ako napr. vrodené anomálie obličiek a močových ciest) ako aj získaným ochoreniam obličiek (infekcie močových ciest, nefrotický syndróm, hemolyticko-uremický syndróm a ďalšie), ktoré sú opísané komplexne od epidemiológie, patofyziológie, cez klinický obraz, diagnostiku až po liečbu a prognózu. Texty zahŕňajú najnovšie diagnostické a terapeutické postupy opierajúce sa o recetné vedecké poznatky. Informácie uvedené v texte môžu významne pomôcť k úspešnému absolvovaniu štátnej skúšky z predmetu Pediatria. Text je starostlivo vybraný a rozsah kondenzovaný tak, aby vyhovoval predovšetkým potrebám pregraduálneho štúdia a zároveň dopĺňal vedomosti a skúsenosti získané na prednáškach a praktických cvičeniach. Učebnica tiež poskytuje základné informácie pre lekárov v špecializačnej príprave.

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Ladislav Kočan-Dušan Rybár-Róbert Rapčan

The autonomic nervous system is a vital component of the peripheral nervous system, responsible for maintaining homeostasis and regulating internal processes within the body. Unlike the voluntary control exerted by the central nervous system, the autonomic nervous system operates involuntarily, innervating smooth organs, vessels, skin glands, and even exerting some influence over skeletal muscles in connection with vegetative functions such as breathing, digestion, and the urinary and gonadal systems. Its impact extends crucially to the cardiac muscles of the heart and plays a significant role in endocrine and metabolic functions, thermoregulation, as well as emotional and behavioral responses, including adaptive reactions to stressors. The aim of this publication is to provide a comprehensive and objective exploration of the anatomical and physiological intricacies of the autonomic nervous system, offering insights into its clinical applications. Within these pages, we meticulously delineate various interventional therapeutic procedures tailored to specific diagnoses related to the autonomic nervous system, aligning each intervention with the anatomical framework of the autonomic system. The efficacy of these procedures is evaluated based on the level of evidence, as per the current recommendations of Evidence-Based Medicine. This publication is primarily crafted for fifth and sixth-year medical students and medical professionals specializing in anesthesiology, intensive care, and pain medicine. It serves as a valuable resource for gaining a deeper understanding of autonomic nervous system function and its clinical implications, facilitating informed decision-making in clinical practice.

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Jana Raková et al.

The proposed university textbook focuses on topics related to nutrition and nutritional recommendations for patients with selected diseases.

The aim is to provide dietary recommendations for patients with cardiovascular diseases, obesity, metabolic syndrome, gastrointestinal and hepatobiliary disorders, and bone and joint diseases. An important part of the content includes nutrition in relation to cancer. Beneficial for the present time is also a chapter focused on food allergies and intolerances.

The publication highlights specific and targeted nutritional interventions as part of the treatment regimen, which is essential to know and follow in a patient's personal life.

PhDr. Jana Raková, PhD.
(on behalf of the authors' collective)

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Eva Slabá-Helena Mičková-Jozef Židzik-Lucia Klimčáková-Janka Vašková

Teaching texts „Practical Lessons in Medical biology“ provide the theoretical foundations of microscopy, various microscopic techniques and preparation of microscopic slides in an understandable form. The chapters of the teaching texts contain model questions and tasks from cytology, molecular biology and genetics enabling students to acquire new knowledge from individual thematic areas and provide instructions for the implementation of tasks during laboratory lessons in medical biology. Teaching texts are primarily intended for the practical lessons in the subjects Biology 1 and Biology 2 for foreign students of the first year of General Medicine and the subjects Medical Biology and Genetics and Regenerative Medicine for foreign students of the first and second year of Dental Medicine at P. J. Šafárik University in Košice – Faculty of Medicine.

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Alžbeta Blichárová a kolektív 

„Patológia 1. časť (zimný semester) - Praktické cvičenia pre študentov všeobecného lekárstva“ je prvou časťou vysokoškolskej učebnice predstavujúcou prvú polovicu výučby (zimný semester). V tejto časti je popísaných 70 diagnóz, kde každej je venovaná jedna strana. V popise je uvedené poradové číslo zhodujúce sa s číslom preparátu a názov danej diagnózy. Študent sa pri každom preparáte oboznámi so základnými informáciami o danej chorobe, jej makroskopickým a mikroskopickým obrazom. Navyše je vytvorené miesto, v ktorom si študent môže zaznačiť (nakresliť) charakteristický mikroskopický obraz danej choroby. Preparáty v tejto učebnici sú zamerané na všeobecnú patológiu – regresívne a progresívne zmeny, pigmentáciu, hojenie, zápaly a nádory.

Tým, že učebnica umožňuje preparáty zakresľovať, vytvára študentom priestor pre trvalejšie zapamätanie si danej problematiky. Je vynikajúcim zdrojom pre prípravu študentov na kolokvium a ústnu skúšku.

Vincent Nagy

Predkladaná monografia sa komplexne venuje problematike urolitiázy. Má 19 kapitol, ktoré zahrňujú celú šírku problematiky urolitiázy a to epidemiológiu, etiológiu, typy konkrementov, osobitné situácie pri urolitiáze, diagnostiku urolitiázy, zobrazovacie vyšetrovacie metódy pri urolitiáze, konzervatívnu liečbu urolitiázy, chirurgické a endoskopické metódy liečby urolitiázy, metafylaxiu konkrementov a konkrementy v močovom mechúri. V monografii sa zdôrazňuje význam individuálneho rozhodovania o optimálnom spôsobe liečby. Do úvahy sa berie veľkosť konkrementov, ich počet, lokalizácia, anatomické predpoklady a röntgenologické charakteristiky. Pri plánovaní aktívnej liečby sa zdôrazňuje význam resp. potreba zobrazovacími metódami vyšetriť aj anatómiu vývodných močových ciest. Nezastupiteľné miesto, najmä v prípadoch viacpočetnej a opakujúcej sa urolitiázy a geneticky podmienenej urolitiázy, má kompletné metabolické vyšetrenie. Dokumentuje všetky moderné spôsoby diagnostiky a liečby urolitázy. Metodicky opisuje liečbu urolitiázy – akútny management pri renálnej kolike, pri urosepse pri konkrementom zablokovanej obličke a v tehotenstve. Prevažná väčšina pacientov s urolitiázou je liečená farmakologicky a semininvazívnymi technikami. Vychádza sa z vlastných skúseností, komentuje využitie extrakorporálnej litotripsie, endoskopických metód, stentov. Monografia venuje pozornosť aj auxiliárnym metódam, ktoré sa používajú v liečbe urolitiázy, liečbe sprievodnej infekcie, poranení obličiek a močových ciest, poranení okolitých orgánov, rôznych spôsobov derivácie moču, krvácania. V závere sú spomenuté kalcifikácie pri obličkových tumoroch.

Autor

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Renáta Suchanová - Lucia Dimunová

The following textbook deals with issues related to communication in medical practice which significantly affects the survival and behaviour of a patient. Communication skills and the attitude of healthcare professionals exercised towards a patient have significant impact on patient’s ability to handle treatment and his or hers co-operation during the process.

This publication is intended to serve as a guide applicable towards deeper knowledge, better comprehension and overall understanding of the mental state of an ill person, his or her needs, stances, behaviour patterns, but also his or her management of the illness. Attention is also paid to the active building of a relationship between the healthcare professional and the patient, with emphasis on respect, truthfulness, and mutual understanding in communication. Particularly accentuated are issues related to specific effective communication skills, methods, and techniques serviceable during interactions with a patient; application of empathy and proactive approach are highlighted.

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Ingrid Hodorová - Květuše Lovásová

The publication is a continuation of the already published university textbook"Ultrasound Anatomy 1" and fills the gap in the medical literary market concerning the ultrasound view of peripheral nerves and vessels of the limbs, and neck as well.

Jozef Radoňak a kol.

Skriptá chirurgická propedeutika predstavujú učebné texty prinášajúce pohl'ad do histórie chirurgie cez všeobecne platné princípy chirurgie, moderné diagnostické a terapeutické metó­dy. Patričná pozornost' sa venuje základom chirurgickej onkológie, úrazovej chirurgie, anesteziológie a resuscitácie ako aj liečbe krvácania, infekcie, šoku či transplantáciám. Súčas­ťou textu sú aj kapitoly z vojnovej chirurgie.

Marek Stupák et al.

Medical Chemistry presents an overview of the most important topics of general, organic and bioinorganic chemistry for students of General and Dental Medicine study programs. Its aim is to provide a theoretical basis for the study of the subject Medical Chemistry and for understanding processes and chemical reactions which are taking place in the human body.

Each topic directly links chemical principles to the processes in living organisms and thus can help the students to clearly see the application of the presented information. Therefore, it also provides a good starting point for further study of Medical Biochemistry, for which the knowledge of these principles is necessary.

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Miriam Kozárová

The publication "News in Diabetology and Lipidology" focuses on extremely relevant topics in diabetology and lipidology, reflecting the state of these issues in light of the recommendations from professional societies from 2019. In diabetology, it primarily addresses the intensification of antidiabetic treatment using modern drug classes—specifically, incretin enhancers and sodium-glucose cotransporter-2 (SGLT-2) inhibitors (gliflozins). Few medical fields have experienced such a development of new pharmacological options as diabetology has in the last two decades. While pharmacotherapy for type 2 diabetes (DM2) was limited to the use of biguanides, sulfonylurea derivatives, and insulin throughout the second half of the last century, recent years have introduced entirely new groups of oral antidiabetics with cardio- and nephroprotective effects. In lipidology, it pertains to the new recommendations from the European Atherosclerosis Society (EAS) with new treatment goals for serum lipids and lipoproteins, including the use of biological therapies.

This textbook is primarily intended for medical students in doctoral studies and doctoral candidates, as well as for physicians preparing for specialization exams in internal medicine, endocrinology, diabetology, metabolic disorders and nutrition, as well as cardiology and angiology. I believe that readers will find information in this publication that will aid them in their studies and translate into their daily clinical practice.

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Mária Pallayová - Soňa Grešová - Pavol Švorc - Ivana Bačová

Adekvátne vedomosti z lekárskej fyziológie sú dôležité pre správne porozumenie funkcií jednotlivých orgánových systémov, ako aj pre diagnostiku a správnu liečbu ochorení. Vysokoškolský učebný text Praktické cvičenia z fyziológie je navrhnutý tak, aby dopĺňal prednášky a semináre z Lekárskej fyziológie. Každá kapitola je rozdelená do niekoľkých častí (Úvod, Princíp, Materiál, Postup, Protokol), aby študentom uľahčila porozumenie jednotlivých tém a bola nápomocná pri vypracovávaní laboratórnych protokolov. Jednotlivé kapitoly zahŕňajú ochranu a bezpečnosť pri práci, úvod do fyziológie, hematológiu, kardiovaskulárny systém, respiračný systém a vylučovací systém. Od študentov sa očakáva, že počas praktických cvičení získajú praktické skúsenosti pri riešení jednotlivých úloh zameraných na oblasť lekárskej fyziológie a budú rozvíjať aj dôležité analytické a komunikačné zručnosti, ktoré im pomôžu analyzovať a prezentovať vedecké dáta.