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Praktické cvičenia z imunológie
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Marián Sabol - Helga Kostelná - Leonard Siegfried
Cieľom učebných textov je poskytnúť študentom medicíny a príbuzných odborov poznatky o základných imunologických metódach, ktoré sa využívajú v klinickej praxi. V učebných textoch sú zahrnuté metódy na vyšetrenie fagocytózy, komplementu, imunoglobulínov, autoprotilátok, HLA molekúl a T lymfocytov. Súčasťou textov sú aj postupy pre izoláciu a stanovenie počtu vybraných typov buniek imunitného systému. Kombinácia klasických metód (rozetové testy, fluorescenčná mikroskopia) a moderných metód (napríklad prietoková cytometria a ELISPOT) umožňuje orientáciu v základných laboratórnych metódach imunológie.
Data sheet
- Method of publication:
- Printed publication
- Authors:
- Marián Sabol - Helga Kostelná - Leonard Siegfried
- Document type:
- Academic textbook - scripts
- Number of pages:
- 66
- Year of publication:
- 2017
- Publication language:
- Slovak
- Faculty:
- Faculty of Medicine
- License:
- Copyright
Thank you for the reviews ! Your comment is submitted
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CYTOCHROME P-450: genetic and population aspects
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I. R. Mavlyanov - A. K. Ashirmetov - Z. I. Mavlyanov - G. J. Jarilkasinova
Need of carrying out a pharmacological genotyping for providing the individualized pharmacotherapy is shown in the monograph based on the analysis of own and literary data of the central link of drug pharmacokinetics– systems of cytochrome P-450, taking into account its genetic polymorphysm.
The monograph is intended for the clinical pharmacologists, geneticists and experts dealing with this problem.
Elementary organic molecules in biochemistry
Nature, as well as the human body, contains an abundant quantity of organic molecules. This textbook describes selected oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds of their reactions, which are important in the human body or are found in pharmaceutical active substances, poisons, foodstuffs and heat-treated food. The last part of the textbook describes the isomerism of organic compounds, which enables dynamic changes in the structure of molecules that have different properties. Nature is filled with different plants and animals and is the first laboratory to produce bioactive organic natural compounds. These compounds are compatible with human cells and are applicable as therapeutic medicine. There is an effort to reproduce natural molecules in chemical laboratories, but they cannot be as perfect as the natural ones. Synthetic molecules can serve as a model for multiple studies, but there still does not exist a magic panacea pill or a perfect copy of nature, for the treatment of various diseases. Knowledge about the regenerative and toxic effect of medicinal substances in dependence on their structure (type and number of substituents) is very important for the understanding of their role in modulation of health and disease in dependence on their concentration. Compounds can be used daily only in recommended doses (higher doses can be toxic), but still will not replace a healthy diet. People need a varied diet to be healthy, in which are all necessary nutrients, what Hippocrates demonstrated long ago “Let food be the medicine, and let medicine be the food.” This book is written for students who select bioorganic chemistry subject during the study of general medicine or dentistry as well as for motivated students who would like to practice their knowledge and wish to improve in this subject and for students who would like to learn simplified basic organic reactions with their future application in biochemistry. Learn the simple models mainly through creative simple instruction by using different colours, by repetition, practice by drawing of formulas by hand (at least three times) and memorization of common names of compounds and their reactions which have application in biochemistry. Thus, establishing simple educational methods how to distinguish organic molecules according to the colours of a functional group can promote universal learning for all students who thought that chemistry is a difficult subject, but hopefully they change their opinion after study of this book.
Keywords: organic molecules, oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds, chemical reactions, isomerism of organic compounds
História univerzitnej nemocnice Louisa Pasteura...
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Základná teória fyziologických, fyzikálnych a...
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The textbook provides a clear view of the importance of respiratory care, with an emphasis on prevention and treatment procedures. The introductory chapters present the anatomical and physiological principles of respiratory function necessary for understanding further contexts of the issue. Methods for facilitating expectoration of mucus and foreign bodies are explained. Great emphasis is placed on correct procedures for humidifying and warming the inhaled mixture, including the basics of aerosol therapy. This is an issue that is particularly important in invasive, but also non-invasive methods of ventilation therapy. The work also contains more detailed physical justifications for the explained principles. From a practical perspective, the chapters that draw attention to frequent errors in the use of humidification and aerosol technologies are also important. The texts are supplemented with many illustrative original images and explanations.
The textbook is intended primarily for doctors, nurses and physiotherapists working in the fields of anaesthesiology and intensive care, emergency medicine, in all workplaces that are dedicated to the treatment and care of patients with respiratory problems, such as pneumology, internal medicine, surgical units treating patients in the postoperative period. Last but not least, it is also an excellent supplementary study material for medical students, nursing students and paramedics.
Sledovanie vybraných faktorov životného štýlu...
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The scientific monograph focuses on health determinants, healthy nutrition, its fundamental components, the consequences of unhealthy nutrition, and alternative dietary trends. The work also includes research targeting selected lifestyle factors among university students, particularly nutrition, eating habits, and physical activity.
This scientific monograph is suitable for the scientific community, students of medical and natural sciences, and public health professionals at all three levels of higher education. It is equally valuable for members of the informed general public interested in the subject.
Pathology Part 1 Practical lesons for students...
Alžbeta Blichárová a kolektív
“Pathology Part 1 (winter semester) - Practical lessons for students of general medicine” represents the first half of the university textbook designed for the pregradual study of pathology. The textbook complements the lectures of pathology and serves as a source of information for students of general medicine, that are preparing for the practical as well as the final oral examination.
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Chirurgia srdca pre medikov
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The textbook "Heart surgery for medics" was created in response to repeated requests from students of the Faculty of Medicine P.J.Šafárik University, for the surgery state exam study material. In terms of content, the text corresponds to the required knowledges in cardiac surgery, needed to pass the state exam in surgery. Orientation in the issue of cardiac surgery is not only necessary for students whose specialization will be closely related to the given field. Basic knowledge of cardiac surgery is necessary for every medical faculty graduate. Knowing the treatment options, but also the possible complications of individual cardiac surgical procedures, is necessary for most medical specialties. Only by mastering the basics of each medical field can the patient be properly, adequately and modernly managed.
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The scientific monograph is the output of the Care4Youth project, which aimed to map the current system of care for adolescents with emotional and behavioral problems (EBP) in Slovakia. It captures what the care system is and what its possible shortcomings are from the perspective of all those affected (adolescents with problems, their parents, care providers and other institutions involved).
It also looks at the trajectory of adolescents with EBP in the care system, i.e. when and how adolescents with problems enter and leave the care system, or pass from one type of care to another and what impact different trajectories have on them.
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Medical Biophysics: Practical Exercises
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Progress in biology and medicine has always been significantly related to advances in physics. Not only has physics supplied instruments and methods of measurement that have led to many discoveries in physiology and medicine, but methods of physical research have changed many of the older approaches to the biologic sciences. Such circumstances have even led to development of a new scientific field: biophysics, which uses to a great extent physical instrumentation procedures applied to an experimental system. Because any instrument is an additional factor in any experimental system, it may affect the data. To interpret physical data on biological material correctly then, it is necessary to consider the characteristics of instrument response.
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There are two kinds of lessons in practical courses. The first one focuses on laboratory measurements of some important physical quantities and the evaluation of the measured data. These measured quantities are components of the subject “medical biophysics” or of the phenomena studied. Experience provided in managing various scales and tables, as well as in the construction of tables and graphs is substantial. Lessons also enable students to repeat and to strengthen their knowledge of secondary school physics, which is useful for understanding of many phenomena studied in medical biophysics. The second kind of lesson provides experience with some of the diagnostic and therapeutic medical instruments, which can be seen in practical medicine.
The understanding of basic physical principles of corresponding instruments is both recommended and demanded. Theoretical preparation is not only an appropriate condition for the practical managing of the whole lesson, but also helps to avoid injury. This textbook, therefore, intends to help students in preparing for both the practical lessons and the final exam.
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Zdravie na dosah
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Slovakia has one of the highest mortality rates from preventable and treatable causes. The latest data also shows that within the EU, we have the highest mortality rate from cancer. A person's health is influenced by a combination of genetics, different life circumstances, and personal decisions. While we do not have control over all of these factors, proper eating habits, regular physical activity, and quality sleep can significantly contribute to preventing health problems and chronic diseases. However, many people face barriers such as financial constraints, work overload, or a lack of reliable information and knowledge. In Slovakia, almost half of the population cannot afford to purchase nutritious food, which makes the situation even more difficult. Therefore, we have prepared a practical guide with simple, affordable, and time-efficient recommendations aimed at improving health and quality of life. The publication provides an overview of the latest research and expert recommendations related to healthy eating, sleep hygiene, physical activity, mental health improvement, building resilience and healthy relationships, and also includes important advice on how to increase motivation for health behaviour change.
Environment a jeho etické aspekty
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Ethics, as the science of the proper realization of human potential in various areas of life, also extends into the environment. For understanding the ethical aspects in this field, a thorough knowledge of the individual components of the environment, as well as their impact not only on humans but on all living nature, is very important. Therefore, questions concerning the influence of the environment are increasingly at the forefront of interest from an ethical perspective, also in connection with existing legal norms.
The modern process of civilization is characterized by rapid development of science and technology. However, this development, while raising the standard of living on one hand, also brings negative side effects on the other. The result is the disruption of ecological, biological, and natural life conditions, especially in the areas of industrial centers. The development of individual branches of industry leads to the production of liquid, gaseous, and solid wastes, the emergence of harmful risk factors threatening various components of living nature, including humans. There may be increased bioaccumulation of hazardous chemical elements in organisms, which, through their effects, represent a potential risk also in terms of carcinogenesis and mutagenesis.
For this reason, an important role of society is to create conditions to prevent the release of emissions and to reduce their concentration to the lowest possible, socially and biologically acceptable level. The assessment of the biological effects of harmful substances is based on experimental and epidemiological studies. Knowledge of concentration and duration of exposure is crucial for applying dose-effect relationships and for determining the highest permissible concentrations of pollutants. The health of the population, as a universal value and a primary human right, represents a fundamental economic resource not only for the individual, but also for society as a whole.
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The present multimedia university textbook is intended for students of the bachelor's degree programme in nursing, not excluding both medical and nursing degree courses.
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Základy histológie I. Učebnica a mikroskopický...
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The peer-reviewed textbook and microscopic atlas is aimed at understanding the basic microscopic structure of cells and tissues in a light microscope. Texts in the textbook are complemented by a rich set of histologic micrographs with basic and specific staining techniques.
All histologic micrographs were prepared by the author's team at the Department of Histology and Embryology, Faculty of Medicine, UPJŠ.
Štúdie zdravotného a nutričného stavu populácie...
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This manual is published as an auxiliary methodological script for students of bachelor and master courses of medical faculties - especially bachelor and master courses of ‘Public Health’.
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Clinical Biochemistry
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Clinical Biochemistry - selected chapters - MEFANET >>>
After 7 years, we finally reworked the textbook on the subject of clinical biochemistry at UPJŠ FM in Košice. We have innovated information in accordance with recommendations of professional medical societies and added new chapters. As the scope of the subject is limited, the textbook does not cover all issues of biochemical diagnostics. It focuses on disorders of water-ion and acid-base balance disorders, and basic laboratory diagnostics of diseases of selected organs.
The textbook of clinical biochemistry has the ambition to become a practical aid for senior medical students and beginning doctors in the study of laboratory medicine. It should make it easier for them to orientate themselves in routinely used clinical-biochemical examinations and could form a springboard for a more detailed studying of laboratory methods and their use in diagnostic and monitoring algorithms.
Like any medical discipline, clinical biochemistry is evolving rapidly and gradually integrating with other areas of laboratory medicine. New diagnostic methods penetrate deeper into the essence of the biochemical mechanisms of the human body, and "omic" methods are gaining ground. It is almost sure that in a few years, laboratory examination looks quite different from today. If this publication quite hypothetically reaches its next edition, many chapters will need to updated, and new chapters written following the up-to-date status.
Authors thanks to their colleagues and reviewers for their professional comments and constructive criticism of the text - prof. Jaroslav Racek, MD, DrSc. from FM UK in Pilsen.
Authors thanks very kindly too prof. MUDr. Dušan Dobrota, CSc. (JFM UK Martin) and doc. MVDr. Zuzana Kostecká, PhD. (UVMP, Košice), who read and wrote review of this textbook.
CYTOCHROME P-450: genetic and population aspects
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I. R. Mavlyanov - A. K. Ashirmetov - Z. I. Mavlyanov - G. J. Jarilkasinova
Need of carrying out a pharmacological genotyping for providing the individualized pharmacotherapy is shown in the monograph based on the analysis of own and literary data of the central link of drug pharmacokinetics– systems of cytochrome P-450, taking into account its genetic polymorphysm.
The monograph is intended for the clinical pharmacologists, geneticists and experts dealing with this problem.
Elementary organic molecules in biochemistry
Nature, as well as the human body, contains an abundant quantity of organic molecules. This textbook describes selected oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds of their reactions, which are important in the human body or are found in pharmaceutical active substances, poisons, foodstuffs and heat-treated food. The last part of the textbook describes the isomerism of organic compounds, which enables dynamic changes in the structure of molecules that have different properties. Nature is filled with different plants and animals and is the first laboratory to produce bioactive organic natural compounds. These compounds are compatible with human cells and are applicable as therapeutic medicine. There is an effort to reproduce natural molecules in chemical laboratories, but they cannot be as perfect as the natural ones. Synthetic molecules can serve as a model for multiple studies, but there still does not exist a magic panacea pill or a perfect copy of nature, for the treatment of various diseases. Knowledge about the regenerative and toxic effect of medicinal substances in dependence on their structure (type and number of substituents) is very important for the understanding of their role in modulation of health and disease in dependence on their concentration. Compounds can be used daily only in recommended doses (higher doses can be toxic), but still will not replace a healthy diet. People need a varied diet to be healthy, in which are all necessary nutrients, what Hippocrates demonstrated long ago “Let food be the medicine, and let medicine be the food.” This book is written for students who select bioorganic chemistry subject during the study of general medicine or dentistry as well as for motivated students who would like to practice their knowledge and wish to improve in this subject and for students who would like to learn simplified basic organic reactions with their future application in biochemistry. Learn the simple models mainly through creative simple instruction by using different colours, by repetition, practice by drawing of formulas by hand (at least three times) and memorization of common names of compounds and their reactions which have application in biochemistry. Thus, establishing simple educational methods how to distinguish organic molecules according to the colours of a functional group can promote universal learning for all students who thought that chemistry is a difficult subject, but hopefully they change their opinion after study of this book.
Keywords: organic molecules, oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds, chemical reactions, isomerism of organic compounds
História univerzitnej nemocnice Louisa Pasteura...
Miroslav Mydlík - Július Vajó (eds.)
Základná teória fyziologických, fyzikálnych a...
Jozef Firment a kolektív
The textbook provides a clear view of the importance of respiratory care, with an emphasis on prevention and treatment procedures. The introductory chapters present the anatomical and physiological principles of respiratory function necessary for understanding further contexts of the issue. Methods for facilitating expectoration of mucus and foreign bodies are explained. Great emphasis is placed on correct procedures for humidifying and warming the inhaled mixture, including the basics of aerosol therapy. This is an issue that is particularly important in invasive, but also non-invasive methods of ventilation therapy. The work also contains more detailed physical justifications for the explained principles. From a practical perspective, the chapters that draw attention to frequent errors in the use of humidification and aerosol technologies are also important. The texts are supplemented with many illustrative original images and explanations.
The textbook is intended primarily for doctors, nurses and physiotherapists working in the fields of anaesthesiology and intensive care, emergency medicine, in all workplaces that are dedicated to the treatment and care of patients with respiratory problems, such as pneumology, internal medicine, surgical units treating patients in the postoperative period. Last but not least, it is also an excellent supplementary study material for medical students, nursing students and paramedics.
Sledovanie vybraných faktorov životného štýlu...
E-book
The scientific monograph focuses on health determinants, healthy nutrition, its fundamental components, the consequences of unhealthy nutrition, and alternative dietary trends. The work also includes research targeting selected lifestyle factors among university students, particularly nutrition, eating habits, and physical activity.
This scientific monograph is suitable for the scientific community, students of medical and natural sciences, and public health professionals at all three levels of higher education. It is equally valuable for members of the informed general public interested in the subject.
Pathology Part 1 Practical lesons for students...
Alžbeta Blichárová a kolektív
“Pathology Part 1 (winter semester) - Practical lessons for students of general medicine” represents the first half of the university textbook designed for the pregradual study of pathology. The textbook complements the lectures of pathology and serves as a source of information for students of general medicine, that are preparing for the practical as well as the final oral examination.
In this part of the “Pathology” series, seventy selected histopathological slides are presented. Each selected slide is provided with general information in relation to etiology and pathogenesis of the disease, as well as with corresponding morphological features, including the gross appearance and the most important histopathological characteristics. The textbook summarizes the basic concepts of general pathology that are necessary to master the broad field of systemic pathology in the second semester.
Keywords: general pathology – histopathological slides – general medicine – gross appearance – microscopic image
Chirurgia srdca pre medikov
E-book
Tomáš Toporcer - Adrián Kolesár
The textbook "Heart surgery for medics" was created in response to repeated requests from students of the Faculty of Medicine P.J.Šafárik University, for the surgery state exam study material. In terms of content, the text corresponds to the required knowledges in cardiac surgery, needed to pass the state exam in surgery. Orientation in the issue of cardiac surgery is not only necessary for students whose specialization will be closely related to the given field. Basic knowledge of cardiac surgery is necessary for every medical faculty graduate. Knowing the treatment options, but also the possible complications of individual cardiac surgical procedures, is necessary for most medical specialties. Only by mastering the basics of each medical field can the patient be properly, adequately and modernly managed.
Cesta labyrintom: Dospievajúci s emocionálnymi...
E-book
Zuzana Dankulincová a kol.
The scientific monograph is the output of the Care4Youth project, which aimed to map the current system of care for adolescents with emotional and behavioral problems (EBP) in Slovakia. It captures what the care system is and what its possible shortcomings are from the perspective of all those affected (adolescents with problems, their parents, care providers and other institutions involved).
It also looks at the trajectory of adolescents with EBP in the care system, i.e. when and how adolescents with problems enter and leave the care system, or pass from one type of care to another and what impact different trajectories have on them.
Last but not least, the aim of the monograph was to provide expert information on what are the risk and protective factors that will affect their success in the care system or, conversely, that threaten them. All this in order to support the proposal for improvements in the care system that would benefit all stakeholders.
Medical Biophysics: Practical Exercises
Michal Legiňa kol.
Progress in biology and medicine has always been significantly related to advances in physics. Not only has physics supplied instruments and methods of measurement that have led to many discoveries in physiology and medicine, but methods of physical research have changed many of the older approaches to the biologic sciences. Such circumstances have even led to development of a new scientific field: biophysics, which uses to a great extent physical instrumentation procedures applied to an experimental system. Because any instrument is an additional factor in any experimental system, it may affect the data. To interpret physical data on biological material correctly then, it is necessary to consider the characteristics of instrument response.
A practical course enables a student to acquire some skills, experience and methodological knowledge for performance of experiments and evaluation of measured data. Due to the fast development of instrumentation technology, it is not possible to teach every operation and procedure upon instruments we may use in a future. Besides the basic physical principles, the aim of a practical course is to point out some general rules and skills for instrument operation and for the interpretation of the measured values derived from such operation.
There are two kinds of lessons in practical courses. The first one focuses on laboratory measurements of some important physical quantities and the evaluation of the measured data. These measured quantities are components of the subject “medical biophysics” or of the phenomena studied. Experience provided in managing various scales and tables, as well as in the construction of tables and graphs is substantial. Lessons also enable students to repeat and to strengthen their knowledge of secondary school physics, which is useful for understanding of many phenomena studied in medical biophysics. The second kind of lesson provides experience with some of the diagnostic and therapeutic medical instruments, which can be seen in practical medicine.
The understanding of basic physical principles of corresponding instruments is both recommended and demanded. Theoretical preparation is not only an appropriate condition for the practical managing of the whole lesson, but also helps to avoid injury. This textbook, therefore, intends to help students in preparing for both the practical lessons and the final exam.
Authors
Zdravie na dosah
E-book
Vladimíra Timková a kol.
Slovakia has one of the highest mortality rates from preventable and treatable causes. The latest data also shows that within the EU, we have the highest mortality rate from cancer. A person's health is influenced by a combination of genetics, different life circumstances, and personal decisions. While we do not have control over all of these factors, proper eating habits, regular physical activity, and quality sleep can significantly contribute to preventing health problems and chronic diseases. However, many people face barriers such as financial constraints, work overload, or a lack of reliable information and knowledge. In Slovakia, almost half of the population cannot afford to purchase nutritious food, which makes the situation even more difficult. Therefore, we have prepared a practical guide with simple, affordable, and time-efficient recommendations aimed at improving health and quality of life. The publication provides an overview of the latest research and expert recommendations related to healthy eating, sleep hygiene, physical activity, mental health improvement, building resilience and healthy relationships, and also includes important advice on how to increase motivation for health behaviour change.
Environment a jeho etické aspekty
E-book
Tatiana Kimáková a kol.
Ethics, as the science of the proper realization of human potential in various areas of life, also extends into the environment. For understanding the ethical aspects in this field, a thorough knowledge of the individual components of the environment, as well as their impact not only on humans but on all living nature, is very important. Therefore, questions concerning the influence of the environment are increasingly at the forefront of interest from an ethical perspective, also in connection with existing legal norms.
The modern process of civilization is characterized by rapid development of science and technology. However, this development, while raising the standard of living on one hand, also brings negative side effects on the other. The result is the disruption of ecological, biological, and natural life conditions, especially in the areas of industrial centers. The development of individual branches of industry leads to the production of liquid, gaseous, and solid wastes, the emergence of harmful risk factors threatening various components of living nature, including humans. There may be increased bioaccumulation of hazardous chemical elements in organisms, which, through their effects, represent a potential risk also in terms of carcinogenesis and mutagenesis.
For this reason, an important role of society is to create conditions to prevent the release of emissions and to reduce their concentration to the lowest possible, socially and biologically acceptable level. The assessment of the biological effects of harmful substances is based on experimental and epidemiological studies. Knowledge of concentration and duration of exposure is crucial for applying dose-effect relationships and for determining the highest permissible concentrations of pollutants. The health of the population, as a universal value and a primary human right, represents a fundamental economic resource not only for the individual, but also for society as a whole.
Ošetrovateľstvo v chirurgii I
E-book
Silvia Danková - Lucia Dimunová - Beáta Grešš Halász - Jana Sušinková
The present multimedia university textbook is intended for students of the bachelor's degree programme in nursing, not excluding both medical and nursing degree courses.
The purpose of the present publication is to provide a comprehensive view of the nature of surgical nursing, focusing on the method of providing nursing care - the nursing process. It comprehensively describes the individual steps of perioperative nursing care and the subsequent possible complications associated with surgical procedures. Documents the depth of knowledge and skills training in chronic wound care management issues. Respects the culture of patient and healthcare professional safety.
The college textbook uses e-learning methods in combination with traditional face-to-face education. Based on the latest resources, it respects the concept of health care delivery and professional training of nurses.
Download e-book for free (pdf)
Základy histológie I. Učebnica a mikroskopický...
E-book
Iveta Domoráková - Štefan Tóth - Zuzana Fagová - Kristína Čurgali - Viera Eliášová - Alexandra Kunová - Monika Holodová
The peer-reviewed textbook and microscopic atlas is aimed at understanding the basic microscopic structure of cells and tissues in a light microscope. Texts in the textbook are complemented by a rich set of histologic micrographs with basic and specific staining techniques.
All histologic micrographs were prepared by the author's team at the Department of Histology and Embryology, Faculty of Medicine, UPJŠ.
Štúdie zdravotného a nutričného stavu populácie...
E-book
This manual is published as an auxiliary methodological script for students of bachelor and master courses of medical faculties - especially bachelor and master courses of ‘Public Health’.
Students of general medicine and dentistry can also use these teaching texts as an educational aid when studying the subject “Hygiene”, which is taught either on its own or as part of broader subjects, e.g. “Public Health”.
Clinical Biochemistry
E-book
Eva Ďurovcová - Mária Mareková
Clinical Biochemistry - selected chapters - MEFANET >>>
After 7 years, we finally reworked the textbook on the subject of clinical biochemistry at UPJŠ FM in Košice. We have innovated information in accordance with recommendations of professional medical societies and added new chapters. As the scope of the subject is limited, the textbook does not cover all issues of biochemical diagnostics. It focuses on disorders of water-ion and acid-base balance disorders, and basic laboratory diagnostics of diseases of selected organs.
The textbook of clinical biochemistry has the ambition to become a practical aid for senior medical students and beginning doctors in the study of laboratory medicine. It should make it easier for them to orientate themselves in routinely used clinical-biochemical examinations and could form a springboard for a more detailed studying of laboratory methods and their use in diagnostic and monitoring algorithms.
Like any medical discipline, clinical biochemistry is evolving rapidly and gradually integrating with other areas of laboratory medicine. New diagnostic methods penetrate deeper into the essence of the biochemical mechanisms of the human body, and "omic" methods are gaining ground. It is almost sure that in a few years, laboratory examination looks quite different from today. If this publication quite hypothetically reaches its next edition, many chapters will need to updated, and new chapters written following the up-to-date status.
Authors thanks to their colleagues and reviewers for their professional comments and constructive criticism of the text - prof. Jaroslav Racek, MD, DrSc. from FM UK in Pilsen.
Authors thanks very kindly too prof. MUDr. Dušan Dobrota, CSc. (JFM UK Martin) and doc. MVDr. Zuzana Kostecká, PhD. (UVMP, Košice), who read and wrote review of this textbook.
CYTOCHROME P-450: genetic and population aspects
E-book
I. R. Mavlyanov - A. K. Ashirmetov - Z. I. Mavlyanov - G. J. Jarilkasinova
Need of carrying out a pharmacological genotyping for providing the individualized pharmacotherapy is shown in the monograph based on the analysis of own and literary data of the central link of drug pharmacokinetics– systems of cytochrome P-450, taking into account its genetic polymorphysm.
The monograph is intended for the clinical pharmacologists, geneticists and experts dealing with this problem.
Elementary organic molecules in biochemistry
Nature, as well as the human body, contains an abundant quantity of organic molecules. This textbook describes selected oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds of their reactions, which are important in the human body or are found in pharmaceutical active substances, poisons, foodstuffs and heat-treated food. The last part of the textbook describes the isomerism of organic compounds, which enables dynamic changes in the structure of molecules that have different properties. Nature is filled with different plants and animals and is the first laboratory to produce bioactive organic natural compounds. These compounds are compatible with human cells and are applicable as therapeutic medicine. There is an effort to reproduce natural molecules in chemical laboratories, but they cannot be as perfect as the natural ones. Synthetic molecules can serve as a model for multiple studies, but there still does not exist a magic panacea pill or a perfect copy of nature, for the treatment of various diseases. Knowledge about the regenerative and toxic effect of medicinal substances in dependence on their structure (type and number of substituents) is very important for the understanding of their role in modulation of health and disease in dependence on their concentration. Compounds can be used daily only in recommended doses (higher doses can be toxic), but still will not replace a healthy diet. People need a varied diet to be healthy, in which are all necessary nutrients, what Hippocrates demonstrated long ago “Let food be the medicine, and let medicine be the food.” This book is written for students who select bioorganic chemistry subject during the study of general medicine or dentistry as well as for motivated students who would like to practice their knowledge and wish to improve in this subject and for students who would like to learn simplified basic organic reactions with their future application in biochemistry. Learn the simple models mainly through creative simple instruction by using different colours, by repetition, practice by drawing of formulas by hand (at least three times) and memorization of common names of compounds and their reactions which have application in biochemistry. Thus, establishing simple educational methods how to distinguish organic molecules according to the colours of a functional group can promote universal learning for all students who thought that chemistry is a difficult subject, but hopefully they change their opinion after study of this book.
Keywords: organic molecules, oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds, chemical reactions, isomerism of organic compounds
História univerzitnej nemocnice Louisa Pasteura...
Miroslav Mydlík - Július Vajó (eds.)
Základná teória fyziologických, fyzikálnych a...
Jozef Firment a kolektív
The textbook provides a clear view of the importance of respiratory care, with an emphasis on prevention and treatment procedures. The introductory chapters present the anatomical and physiological principles of respiratory function necessary for understanding further contexts of the issue. Methods for facilitating expectoration of mucus and foreign bodies are explained. Great emphasis is placed on correct procedures for humidifying and warming the inhaled mixture, including the basics of aerosol therapy. This is an issue that is particularly important in invasive, but also non-invasive methods of ventilation therapy. The work also contains more detailed physical justifications for the explained principles. From a practical perspective, the chapters that draw attention to frequent errors in the use of humidification and aerosol technologies are also important. The texts are supplemented with many illustrative original images and explanations.
The textbook is intended primarily for doctors, nurses and physiotherapists working in the fields of anaesthesiology and intensive care, emergency medicine, in all workplaces that are dedicated to the treatment and care of patients with respiratory problems, such as pneumology, internal medicine, surgical units treating patients in the postoperative period. Last but not least, it is also an excellent supplementary study material for medical students, nursing students and paramedics.