Základy lekárskej,klinickej a laboratórnej biochémie

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Pavol Jarčuška - Daniel Pella - Ján Rosocha (eds.)

Proceedings of lectures from thematic conferences organized by UVP MediPark

UVP Medipark – the path to innovation in research, diagnostics, and treatment – was the title of the conference held on Tuesday, May 29, 2018, at the premises of the Faculty of Medicine, Pavol Jozef Šafárik University in Košice. The patronage of the event was taken over by the rector of UPJŠ, Prof. RNDr. Pavol Sovák, CSc. The conference program was divided into two main areas – Innovative scientific technologies, clinical research, and the path to the development of new drugs, and UVP Medipark – main research areas.

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Marek Šoltés - Jozef Radoňak

Laparoscopic surgery today represents the standard and, in many respects, a preferred modality of surgical treatment. The dynamics of its global expansion, enabled by advancements in biomedical technologies and the development of global information and communication channels, is unprecedented in the history of surgery. Currently, there is virtually no abdominal operation that is not performed laparoscopically, with laparoscopic procedures often being the method of choice.

Despite—or perhaps because of—the unprecedentedly rapid penetration of laparoscopic surgeries into everyday surgical practice, universally accepted technical standards are still lacking in many respects. The high variability of procedural approaches within individual laparoscopic operations stems more from the traditions of specific workplaces than from evidence-based medicine. This situation is further influenced by the development of new and revived concepts such as mini-laparoscopy, SILS (Single Incision Laparoscopic Surgery), NOTES (Natural Orifice Transluminal Endoscopic Surgery), and their hybrid combinations with classical laparoscopy.

The aim of this monograph is to draw the attention of the professional community back to the fundamental principles of laparoscopic surgery, which should serve as a foundation for the effective and safe performance of laparoscopic operations, as well as a basis for a critical stance towards fashionable innovative trends.

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Eva Mechírová - Iveta Domoráková

The content of this "Practical lessons" represents a record of the appearance, under the light microscope of the tissues, organs and systems of the human body. In addition, it provides visual guidelines during the practical phase of a histology course. It is hoped that this book will be especially useful to students to understand fully the microscopic structure of human tissues and organs.

Authors

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Štefan Tóth

Dyslipidemia is one of the main risk factors for the development of cardiovascular diseases. In recent years, extensive research has been conducted, leading to changes in therapeutic recommendations for dyslipidemia. These scripts aim to provide readers in the introductory chapters with information on the basic management of patients with dyslipidemia, procedures, target levels, and available medications and their combinations for achieving target levels, focusing on the practical aspect of dyslipidemia treatment. In the special section of the script, an overview is provided of the basic characteristics, studies of individual available hypolipemics, as well as hypolipemics that are not yet on our market or are still in the stage of clinical trials

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Tatiana Kimáková

Táto vedecká monografia je komplexnou vedeckou prácou zameranou na prítomnosť a pôsobenie ortuti v životnom prostredí, ale aj na rizikové faktory zdravia, ktoré sú s ňou spojené. Monografia predstavuje charakteristiku ortuti v multidisciplinárnom zábere, prezentuje využitie v priemysle a v zdravotníctve, popisuje negatívne vplyvy ortuti v životnom prostredí, na zdravotný stav obyvateľstva. Zároveň prináša návrhy a odporúčania pre rizikové skupiny ľudí. Súčasťou monografie je komplexný výskum koncentrácie ortuti vo vzorkách komodít domácej i zahraničnej produkcie a vo vzorkách rastlín pomocou atómového absorpčného spektrometra AMA 254. Vedecká monografia je vhodná pre vedeckú komunitu, študentov medicínskych, veterinárnych, prírodovedných a poľnohospodárskych odborov ako aj pre študentov verejného zdravotníctva všetkých troch stupňov vysokoškolského štúdia. Monografia je učená aj pre všetkých záujemcov z radov informovanej verejnosti.

Autorka

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Dominika Jarčušková

The script deals with the issue of harmful alcohol use and its consequences on individuals’ cognitive abilities. The first part is devoted to the diagnosis of dependence syndrome and the assessment of risky drinking according to internationally recognized classifications (ICD, DSM). The following chapters explain the concept of cognition and its main components. Attention is also given to changes in cognitive functions during long-term alcohol abuse. The reader is introduced to the anatomical changes in the brain caused by alcohol. Damage to white matter and disorders of neurotransmission are described. Special focus is placed on diagnoses associated with alcohol use, such as Korsakoff syndrome, Wernicke’s encephalopathy, demyelinating disorders, and hepatic encephalopathy. Attention is also paid to the possibilities of diagnosing cognitive dysfunction. General screening tests such as MMSE or MoCA are presented. More specific tools, such as PHES or BEARNI, are described in greater detail. The script also points out the possibilities of pharmacological treatment. Non-pharmacological approaches, including cognitive remediation therapy and computer-based training, are also discussed. The conclusion is devoted to modern neuromodulation methods, in particular transcranial magnetic stimulation and transcranial direct current stimulation. This university textbook is primarily intended for students of medicine, psychology, and related health sciences.

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 Ingrid Dravecká 

College textbook "Investigation methods in Diabetology" is designed for students of medicine. It can help them in preparing for an exam from internal medicine but specially in preparing for a state exam from internal medicine. The introduction is devoted to classification and diagnostic criteria of diabetes mellitus. Further It describes investigation options (clinical, laboratory, imaging) of different types of diabetes mellitus as well as its acute and chronic complications. At the end there are given diagnostics and classification of the individual components of the metabolic syndrome, obesity and dyslipidemia.

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Ivana Skoumalová - Zuzana Dankulincová

The publication entitled Competencies for clinical practice in the field of communication with the patient serves as the background and teaching material.

The text is structured to bring theoretical knowledge about the topic, current research findings in the field and practical tips for training skills in practice. It provides clear information on individual parts of the training and is designed to acquire knowledge that is the basis for practical skills in medical communication, especially in communication with patients.

It is intended for general and dental students to deepen their knowledge and acquire missing skills in medical communication, which are evidence-based and research-validated skills that have a demonstrable positive impact on patient communication.

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Iveta Domoráková - Štefan Tóth - Zuzana Fagová - Eva Mechírová - Alexandra Kunová - Kristína Čurgali - Viera Eliášová - Monika Holodová - Marianna Danková

In our new electronic textbook, FUNDAMENTALS OF HISTOLOGY II – Textbook and Atlas of Microscopic Anatomy of Organs, we present students and the professional public with essential information about the microscopic structure of organs, accompanied by extensive visual documentation of organ structures and clear legends for the microphotographs.

All histological specimens come from the archive of the Institute of Histology and Embryology, are used in practical exercises, and are also included in teaching presentations. The electronic textbook is intended for undergraduate and postgraduate students of general medicine and dentistry at medical faculties, as well as for students of veterinary medicine and pharmacy, and biology students at faculties of natural sciences.

The textbook is designed so that students can find clear explanations of most medical terms and also reinforce their knowledge of professional terminology in Latin. An advantage of the electronic textbook is the ability to enlarge microscopic photographs, allowing detailed observation of structures without any qualitative loss of the viewed image. The microphotographs used in the atlas were taken with the following equipment: Zeiss Promicra and Olympus BX50 with a Canon EOS 2000D digital camera and QP Industrial 3.2 software.

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Jana Raková et al.

The proposed university textbook focuses on topics related to nutrition and nutritional recommendations for patients with selected diseases.

The aim is to provide dietary recommendations for patients with cardiovascular diseases, obesity, metabolic syndrome, gastrointestinal and hepatobiliary disorders, and bone and joint diseases. An important part of the content includes nutrition in relation to cancer. Beneficial for the present time is also a chapter focused on food allergies and intolerances.

The publication highlights specific and targeted nutritional interventions as part of the treatment regimen, which is essential to know and follow in a patient's personal life.

PhDr. Jana Raková, PhD.
(on behalf of the authors' collective)

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Peter Olexa

Učebné texty „Vybrané kapitoly z gerontológie a geriatrie" sú určené pre štúdium študentov medicíny na Lekárskej fakulty UPJŠ v odbore Všeobecné lekárstvo v rámci výučby klinických špecializačných blokov v odbore Interná medicína - Geriatria .

Vo svojom úvode sa učebné texty venujú demografii z pohľadu starnutia populácie, vysvetľujú základné pojmy ako gerontológia, jej rozdelenie a následne sa zaoberajú aj úlohou a poslaním klinického odboru geriatria. Následne zrozumiteľne opisujú a vysvetľujú základné piliere geriatrickej medicíny, ktorými sú komplexné geriatrické vyšetrenie, základné geriatrické syndrómy, kam patrí krehkosť, malnutrícia, sarkopénia, kognitívne poruchy, a polyfarmácia . V závere sa venujú ageizmu, ktorý je tiež dôležitým javom v dnešnej klinickej medicíne.

MUDr. Peter Olexa, PhD.

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Miriam Kozárová

Simulation-based medical education has become an integral part of medical education in the 21st century. It represents a modern and effective way to enable medical, nursing, emergency medicine, and other healthcare team members to safely develop clinical skills, decision-making abilities, and teamwork. Simulation-based medical education (SBME) is primarily about opportunities to try out and experience medical/nursing/rescue procedures in a safe environment without any risk to real patients.

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Kvetoslava Rimarová a kol.

Učebnica poskytuje komplexný a interdisciplinárny pohľad na problematiku humánnej výživy v kontexte verejného zdravotníctva, hygieny výživy a prevencie ochorení. Je koncipovaná ako základný aj rozširujúci študijný materiál pre študentov zdravotníckych, biomedicínskych a verejno-zdravotníckych odborov, ako aj pre odborníkov pôsobiacich v oblasti výživy, hygieny, potravinárstva a zdravotnej politiky. Publikácia systematicky pokrýva všetky kľúčové oblasti výživy človeka – od základných zložiek potravy (bielkoviny, sacharidy, tuky, vitamíny, minerálne látky), ich biologickej a energetickej hodnoty, cez odporúčané výživové dávky a tvorbu racionálneho jedálnička, až po hodnotenie nutričného stavu populácie. Osobitná pozornosť je venovaná antioxidantom, probiotikám a funkčným potravinám, ktoré predstavujú moderný a dynamicky sa rozvíjajúci segment výživovej vedy.

Učebnica reflektuje aktuálne trendy v stravovaní vrátane alternatívnych spôsobov výživy, prerušovaného pôstu, vysokoproteínových diét a konzumácie spracovaných a ultraprocesovaných potravín, pričom ich hodnotí z hľadiska vedeckých dôkazov, zdravotných prínosov aj rizík. Dôležitou súčasťou je problematika cudzorodých látok v potravinách, potravinárskych aditív a legislatívnych rámcov ich používania, ako aj význam pitnej vody, jej kvalita, úprava a zdravotné riziká spojené s kontamináciou. Publikácia sa venuje aj špecifickým oblastiam, ako sú alimentárne nákazy, výživa v jednotlivých vývinových obdobiach detí, nemocničné stravovanie a diétne systémy.

Praktickú hodnotu učebnice zvyšuje zaradenie metodicky spracovanej praktickej časti zameranej na mikrobiologické hodnotenie pokrmov rýchleho občerstvenia, založenej na reálnych dátach regionálnych úradov verejného zdravotníctva. Text je spracovaný prehľadne, s využitím tabuliek, obrázkov a aktuálnej odbornej literatúry, čo umožňuje čitateľovi nielen osvojenie teoretických poznatkov, ale aj ich aplikáciu v praxi. Učebnica predstavuje ucelený, moderný a vedecky podložený zdroj poznatkov o výžive ako jednom zo základných determinantov zdravia populácie.

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Ahmad Gharaibeh - Marek Lacko

Authors describe the clinical and paraclinical examination methods necessary for the diagnosis and treatment of orthopedic diseases in both children and adults.

The examination methods are categorized based on individual anatomical locations. A valuable chapter discusses joint aspirations, detailing their indications, techniques for performing them, and potential complications. The chapter showcasing patient documentation for students serves as a significant aid for practical exams before the state final examination in surgery.

This work appropriately complements the available educational literature required for international undergraduate students in general medicine, as well as for physicians in specialized training in orthopedics and related fields.

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Dominik Šafčák

Both clinical and radiation oncology are the most developing parts of medicine. Regardless of the physician´s specialization, all of them will have to face subjects with cancer in their daily clinical practice. It includes not only the treatment itself, but also obtaining the diagnosis, but also differential diagnosis and treatment of different adverse events caused by oncological treatment. This publication provides basic data about tumor characteristics necessary for oncologists to determine the final stage and choose the best treatment strategy. In addition, explains the basic oncological terms, forms of therapy, and provides information about treatment timing, combination strategies and expected outcomes. It explains main endpoints of clinical trials performed in oncology to understand them.  In the second part this publication describes mechanism of action of all treatment modalities used in clinical oncology, provides information about potential side effects and basic knowledge how to deal with them. The last chapter is focused on palliative care, how to relieve symptoms of dying patient and how to deal with cancer-related pain. 

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Vladimíra Tomečková

Nature, as well as the human body, contains an abundant quantity of organic molecules. This textbook describes selected oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds of their reactions, which are important in the human body or are found in pharmaceutical active substances, poisons, foodstuffs and heat-treated food. The last part of the textbook describes the isomerism of organic compounds, which enables dynamic changes in the structure of molecules that have different properties. Nature is filled with different plants and animals and is the first laboratory to produce bioactive organic natural compounds. These compounds are compatible with human cells and are applicable as therapeutic medicine. There is an effort to reproduce natural molecules in chemical laboratories, but they cannot be as perfect as the natural ones. Synthetic molecules can serve as a model for multiple studies, but there still does not exist a magic panacea pill or a perfect copy of nature, for the treatment of various diseases. Knowledge about the regenerative and toxic effect of medicinal substances in dependence on their structure (type and number of substituents) is very important for the understanding of their role in modulation of health and disease in dependence on their concentration. Compounds can be used daily only in recommended doses (higher doses can be toxic), but still will not replace a healthy diet. People need a varied diet to be healthy, in which are all necessary nutrients, what Hippocrates demonstrated long ago “Let food be the medicine, and let medicine be the food.” This book is written for students who select bioorganic chemistry subject during the study of general medicine or dentistry as well as for motivated students who would like to practice their knowledge and wish to improve in this subject and for students who would like to learn simplified basic organic reactions with their future application in biochemistry. Learn the simple models mainly through creative simple instruction by using different colours, by repetition, practice by drawing of formulas by hand (at least three times) and memorization of common names of compounds and their reactions which have application in biochemistry. Thus, establishing simple educational methods how to distinguish organic molecules according to the colours of a functional group can promote universal learning for all students who thought that chemistry is a difficult subject, but hopefully they change their opinion after study of this book.

Keywords: organic molecules, oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds, chemical reactions, isomerism of organic compounds