Základy lekárskej,klinickej a laboratórnej biochémie

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Martina Šemeláková (ed.)

Proceedings contain abstracts from participants of the scientific conference with international participation under the name: Student scientific international conference GenICa”, supported by the project "Bilateral relations and common knowledge between Slovakia and Iceland research at Universities on the topic "Genomic instability and cancer "GenICa", funded under the EEA and Norwegian 2014-2021 Financial Mechanism Programme (FBR02, bilateral initiatives under the Fund for Bilateral Relations at national level co-financed by EEA and Norwegian Financial Mechanism 2014-2021) which took place on 19 - 21 June 2024 in the premises of Hotel Sorea Trigan, Štrbské Pleso, Slovakia.

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Miriam Kozárová

The publication "News in Diabetology and Lipidology" focuses on extremely relevant topics in diabetology and lipidology, reflecting the state of these issues in light of the recommendations from professional societies from 2019. In diabetology, it primarily addresses the intensification of antidiabetic treatment using modern drug classes—specifically, incretin enhancers and sodium-glucose cotransporter-2 (SGLT-2) inhibitors (gliflozins). Few medical fields have experienced such a development of new pharmacological options as diabetology has in the last two decades. While pharmacotherapy for type 2 diabetes (DM2) was limited to the use of biguanides, sulfonylurea derivatives, and insulin throughout the second half of the last century, recent years have introduced entirely new groups of oral antidiabetics with cardio- and nephroprotective effects. In lipidology, it pertains to the new recommendations from the European Atherosclerosis Society (EAS) with new treatment goals for serum lipids and lipoproteins, including the use of biological therapies.

This textbook is primarily intended for medical students in doctoral studies and doctoral candidates, as well as for physicians preparing for specialization exams in internal medicine, endocrinology, diabetology, metabolic disorders and nutrition, as well as cardiology and angiology. I believe that readers will find information in this publication that will aid them in their studies and translate into their daily clinical practice.

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Tatiana Kimáková a kol.

Ethics, as the science of the proper realization of human potential in various areas of life, also extends into the environment. For understanding the ethical aspects in this field, a thorough knowledge of the individual components of the environment, as well as their impact not only on humans but on all living nature, is very important. Therefore, questions concerning the influence of the environment are increasingly at the forefront of interest from an ethical perspective, also in connection with existing legal norms.

The modern process of civilization is characterized by rapid development of science and technology. However, this development, while raising the standard of living on one hand, also brings negative side effects on the other. The result is the disruption of ecological, biological, and natural life conditions, especially in the areas of industrial centers. The development of individual branches of industry leads to the production of liquid, gaseous, and solid wastes, the emergence of harmful risk factors threatening various components of living nature, including humans. There may be increased bioaccumulation of hazardous chemical elements in organisms, which, through their effects, represent a potential risk also in terms of carcinogenesis and mutagenesis.

For this reason, an important role of society is to create conditions to prevent the release of emissions and to reduce their concentration to the lowest possible, socially and biologically acceptable level. The assessment of the biological effects of harmful substances is based on experimental and epidemiological studies. Knowledge of concentration and duration of exposure is crucial for applying dose-effect relationships and for determining the highest permissible concentrations of pollutants. The health of the population, as a universal value and a primary human right, represents a fundamental economic resource not only for the individual, but also for society as a whole.

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Martina Chylová - Lívia Peštová

Učebné texty Psychológia v medicíne prezentujú základné poznatky o správaní sa a prežívaní človeka nielen v chorobe, približujú psychodiagnostické postupy a psychoterapeutickú liečbu pacientov. Podstatnou súčasťou práce je kapitola, ktorá pojednáva o lekárskej psychológii. Táto časť práce poukazuje na význam komunikácie a interakcie medzi lekárom a pacientom a nutnosť zohľadnenia významných vzťahových aspektov medzi nimi. Kapitola sa ďalej venuje psychosomatickému rozmeru vybraných chorôb v kontexte rôznych medicínskych odborov. Zároveň je analyzovaná psychologická problematika pacientov s telesným, zmyslovým postihnutím a duševne zaostalých osôb, záver učebnice predstavuje opis špecifík práce s detským pacientom. Pomocou týchto učebných textov si študenti medicíny majú osvojiť základné psychologické poznatky, získať vedomosti o efektívnej komunikácii s pacientmi, príbuznými a ostatným zdravotníckym personálom, tvorivo pristupovať k riešeniu problémov pri práci. Zároveň práca zdôrazňuje potrebu duševnej hygieny a starostlivosti o seba, ktorá je v práci lekára nevyhnutná.

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Ahmad Gharaibeh - Marek Lacko

Authors describe the clinical and paraclinical examination methods necessary for the diagnosis and treatment of orthopedic diseases in both children and adults.

The examination methods are categorized based on individual anatomical locations. A valuable chapter discusses joint aspirations, detailing their indications, techniques for performing them, and potential complications. The chapter showcasing patient documentation for students serves as a significant aid for practical exams before the state final examination in surgery.

This work appropriately complements the available educational literature required for international undergraduate students in general medicine, as well as for physicians in specialized training in orthopedics and related fields.

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Mária Pallayová - Štefan Kujaník

The “Textbook of Practical Physiology, Part I - Cardiovascular Physiology” by Mária Pallayová and Štefan Kujaník is a practical textbook of Human Physiology intended for English speaking medical students from general medicine and dentistry curricula.

The textbook covers basic principles in cardiovascular physiology and methods of the cardiovascular examination. Adequate knowledge of the cardiovascular physiology is important for the understanding of cardiovascular system function, as well as for the diagnosis and proper treatment of cardiovascular and other diseases. The practical tasks are constructed to facilitate knowledge acquisition and encourage students to develop practical skills, for instance the ability to follow experimental protocols, to work as part of a team, and to interpret data.

The textbook is written in English and comprises 91 pages in B5 format, grouped into twelve chapters. Each chapter is divided into six sections (Introduction, Principle, Importance, Materials, Procedure, and Protocol) to facilitate students’ understanding of the topics and assist them with preparation of the laboratory reports. The text is accompanied by explanatory figures, graphs, and tables that contribute to the learning experience.

Authors

Vincent Nagy

Predkladaná monografia sa komplexne venuje problematike urolitiázy. Má 19 kapitol, ktoré zahrňujú celú šírku problematiky urolitiázy a to epidemiológiu, etiológiu, typy konkrementov, osobitné situácie pri urolitiáze, diagnostiku urolitiázy, zobrazovacie vyšetrovacie metódy pri urolitiáze, konzervatívnu liečbu urolitiázy, chirurgické a endoskopické metódy liečby urolitiázy, metafylaxiu konkrementov a konkrementy v močovom mechúri. V monografii sa zdôrazňuje význam individuálneho rozhodovania o optimálnom spôsobe liečby. Do úvahy sa berie veľkosť konkrementov, ich počet, lokalizácia, anatomické predpoklady a röntgenologické charakteristiky. Pri plánovaní aktívnej liečby sa zdôrazňuje význam resp. potreba zobrazovacími metódami vyšetriť aj anatómiu vývodných močových ciest. Nezastupiteľné miesto, najmä v prípadoch viacpočetnej a opakujúcej sa urolitiázy a geneticky podmienenej urolitiázy, má kompletné metabolické vyšetrenie. Dokumentuje všetky moderné spôsoby diagnostiky a liečby urolitázy. Metodicky opisuje liečbu urolitiázy – akútny management pri renálnej kolike, pri urosepse pri konkrementom zablokovanej obličke a v tehotenstve. Prevažná väčšina pacientov s urolitiázou je liečená farmakologicky a semininvazívnymi technikami. Vychádza sa z vlastných skúseností, komentuje využitie extrakorporálnej litotripsie, endoskopických metód, stentov. Monografia venuje pozornosť aj auxiliárnym metódam, ktoré sa používajú v liečbe urolitiázy, liečbe sprievodnej infekcie, poranení obličiek a močových ciest, poranení okolitých orgánov, rôznych spôsobov derivácie moču, krvácania. V závere sú spomenuté kalcifikácie pri obličkových tumoroch.

Autor

Martina Vidová Ugurbas

Plastická chirurgia je vysoko špecializovaný medicínsky odbor, ktorý sa zaoberá korekciou defektov, rekonštrukciou a zdokonaľovaním ľudského tela.

Náplňou plastickej chirurgie je korekcia rôznych defektov, vrodených i získaných. Medzi vrodené chyby patria deformity tváre, rázštepy pery a podnebia, deformity ušnice, vrodené vývojové chyby končatín. Najčastejšie získané defekty sú po poraneniach, po chirurgických výkonoch, po fyzikálnych poškodeniach kože a štruktúr krytých kožou.

Do plastickej chirurgie patrí i estetická chirurgia, onkochirurgia a mikrochirurgia, ktorá si zaslúži osobitnú pozornosť. Novými trendami v estetickej chirurgii je rekonštrukcia pomocou tukového tkaniva, kmeňových buniek, používanie rôznych umelých materiálov a implantátov.

Predložené učebné texty v jednotlivých kapitolách popisujú základné princípy plastickej chirurgie, používanie lalokových plastík a iné možnosti krytia defektov. V ôsmych kapitolách sú jednotlivo popísané chirurgické možnosti rekonštrukcie tváre, trupu a končatín. Učebné texty venujú pozornosť malígnym a benígnym kožným tumorom a ich liečbe. Posledná kapitola sa zaoberá najčastejšími estetickými operáciami ako sú augmentácia a redukcia prsníkov, facelifting či blefaroplastika.

E-book

Iveta Domoráková et al.

The e-learning textbook is available at: https://portal.lf.upjs.sk. The textbook contains 11 chapters focusing on the microscopic anatomy of the head and neck region, with an emphasis on the oral and nasal cavities, skull bones and their development, and the detailed microscopic structure of teeth and their development. One chapter is dedicated to dentition from the perspective of the clinical significance of understanding tooth structure and development. The textbook includes chapters on the microscopic anatomy of organs that are functionally important for the head region, such as the vascular, lymphatic, endocrine, and nervous systems. The textbook is linked to an atlas, has a total of 490 pages, and features 300 original microphotographs using common histological stains, histochemical, immunohistochemical, and impregnation methods.

The textbook was created with the support of the KEGA project 019UPJŠ-4/2016.

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 Ingrid Dravecká 

College textbook "Investigation methods in Diabetology" is designed for students of medicine. It can help them in preparing for an exam from internal medicine but specially in preparing for a state exam from internal medicine. The introduction is devoted to classification and diagnostic criteria of diabetes mellitus. Further It describes investigation options (clinical, laboratory, imaging) of different types of diabetes mellitus as well as its acute and chronic complications. At the end there are given diagnostics and classification of the individual components of the metabolic syndrome, obesity and dyslipidemia.

Author

E-book

Mária Rašiová

Cardiovascular diseases are among the main causes of morbidity and mortality in developed countries. Academic textbook: Selected Chapters from Angiology is devoted to the most common vascular diseases that the angiologist encounters on a daily basis.

Dilated artery diseases (abdominal aortic aneurysm), as well as stenotizing diseases of peripheral arteries, are described. Diseases such as deep vein thrombosis, thrombophlebitis and chronic venous insufficiency are discussed in the venous vascular system section. I also deal with the most common lymphatic vascular system disease ˗ lymphoedema.

In the individual chapters the risk factors of the diseases, symptoms and signs, diagnostics, treatment modalities (pharmacological therapy, endovascular therapy, angiosurgical therapy) and possible complications of the therapy are briefly analyzed.

My priority was to present the information in a logical, interesting and comprehensible form for students and for common clinical practice.

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Iveta Cimbolákováa kol.

The premise “today’s research shapes the healthcare of tomorrow” expresses the importance of medical research and the reason for its pursuit. Scientific research and advances in biomedical sciences, as well as their application in medical practice and in the process of delivering healthcare, nevertheless bring new problems in the area of ethics.

Biomedical research itself requires the precise definition of hypotheses, which are tested both under laboratory conditions and on experimental animals. Although clinical studies on human subjects are expected to benefit individual participants and to advance fundamental biomedical knowledge, they also entail certain risks depending on the nature of the research. These risks must be minimized, and the experiment should be conducted freely while also taking place within specific measures to protect all involved-not only the test subjects, but also the researchers themselves.

The presented publication provides an overview of the general conditions and ethical principles of research involving laboratory animals and human subjects, the issue of professional and ethical assessment of projects, as well as fraud and the publication of results. At present, we are witnessing tremendous progress in molecular biological sciences, which brings ethical dilemmas also in the field of genetics. For this reason, one of the chapters is devoted to the latest findings in this area.

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Peter Berek

With the development of endovascular surgery, there is a gradual advancement in ACI stenting. The minimally invasive approach has made this methodology suitable for patients with serious concomitant cardiac or pulmonary diseases. Another advantage compared to surgical treatment was better access to the ICA in patients after radiotherapy, after previous neck surgeries, as well as in patients with stenoses close to the skull base.

The comparison of CEA vs CAS is an interesting and debatable topic in many studies. However, despite the massive global development of endovascular treatment, carotid endarterectomy remains the gold standard for treating ICA stenosis in both symptomatic and asymptomatic patients. In this monograph, we would like to accentuate and systematize the issue of surgical stroke prevention from the perspective of a vascular surgeon.

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Dominik Šafčák

Both clinical and radiation oncology are the most developing parts of medicine. Regardless of the physician´s specialization, all of them will have to face subjects with cancer in their daily clinical practice. It includes not only the treatment itself, but also obtaining the diagnosis, but also differential diagnosis and treatment of different adverse events caused by oncological treatment. This publication provides basic data about tumor characteristics necessary for oncologists to determine the final stage and choose the best treatment strategy. In addition, explains the basic oncological terms, forms of therapy, and provides information about treatment timing, combination strategies and expected outcomes. It explains main endpoints of clinical trials performed in oncology to understand them.  In the second part this publication describes mechanism of action of all treatment modalities used in clinical oncology, provides information about potential side effects and basic knowledge how to deal with them. The last chapter is focused on palliative care, how to relieve symptoms of dying patient and how to deal with cancer-related pain. 

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Darina Kluchová 

Martina Zavacká a kolektív

Kniha „DIABETICKÁ NOHA Z POHĽADU CIEVNEHO CHIRURGA“ obsahuje 14 kapitol. Pojednáva o syndróme diabetickej nohy z multidisciplinárneho pohľadu viacerých odborníkov: angiochirurga, diabetológa, chirurga, podiatra, röntgenológa, neurológa a algeziológa. Úvodné kapitoly majú charakter propedeutiky, čo má taktiež význam aj pre pregraduálnu výchovu. Nasledujúce kapitoly sa zaoberajú vznikom syndrómu, výskytom, jeho diagnostikou, terapeutickými postupmi, pridruženými postihnutiami neurologického charakteru, starostlivosťou podiatra a algeziológa pri pretrvávaní bolestí. Ďalšie časti sú vyhradené chirurgickej a endovaskulárnej liečbe tepien cestou cievneho chirurga a intervenčných angiológov. Nezabúdajúc na problematiku amputácií a správnu rehabilitáciu pacientov s diabetom.  V knihe nájdu poučenie cievni chirurgovia, angiológovia, všeobecní chirurgovia, diabetológovia, neurológia, röntgenológovia, podiatri  a všeobecní lekári.

Kniha je zdrojom najnovších teoretických i praktických informácií pre postgraduálnu výchovu vyššie spomenutých odborníkov.

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