Vybrané úlohy a výpočty z biochémie – metabolizmus

Ján Kleban a kolektív

Predkladaný pracovný zošit na praktické cvičenia z cytológie je určený poslucháčom 1. ročníka bakalárskeho štúdia biológie a 1. ročníka bakalárskeho medziodborového štúdia v kombinácii s biológiou na Prírodovedeckej fakulte Univerzity Pavla Jozefa Šafárika v Košiciach. Slúži ako návod, ktorý má študentom uľahčiť prácu a umožniť rýchlejšiu orientáciu v zadanej úlohe. Úprava pracovného zošita do formy protokolov umožňuje študentom zakresliť vlastné pozorovanie a tým stimuluje študentov k presnejšiemu a trvalejšiemu zapamätaniu si precvičovanej úlohy a zároveň umožňuje spätnú kontrolu pedagógom. Počas cvičení sa študenti postupne oboznámia so základnými pojmami optiky, s aplikáciami využívajúcimi mikroskopickú techniku, ale aj so základnými rozdielmi medzi štruktúrou rastlinnej a živočíšnej bunky a ich organelami.

Adriana Zeleňáková

Magnetic nanoparticles are extremely interesting magnetic objects that still hide much that is undiscovered, both because of their physical properties and because of their diverse applications. Iron nanoparticles, or iron oxides, are used in medical diagnostics for magnetic resonance imaging, in the treatment of hyperthermia, and an important application is the use of magnetic particles for targeted drug delivery.

The textbook "Magnetic Nanoparticles: Nanomagnetism, Preparation and Advanced Applications" is intended primarily for students of the Master's programme in Physics and students of related disciplines at universities and faculties with a physical, chemical, metallurgical and biophysical focus. The motivation for writing this textbook was to develop study material that would contribute to improving the quality of teaching in the profile subject Nanomaterials and Nanotechnology at the Institute of Physical, Faculty of Sciences, UPJŠ, in the Master's programme Condensed Matter Physics, as well as in the profile subject in the PhD programme Advanced Materials.

The university textbook is divided into eight chapters. The first and second chapters are devoted to basic information about magnetism, the origin of nanomagnetism in nanoparticles and surface phenomena. The third and fourth chapters are devoted to nanomagnetism in nanoparticle systems. The fifth chapter describes in detail individual protocols for investigating the phenomenon of superparamagnetism and the phenomenon of superspin glass using the SQUID device. The sixth chapter describes individual procedures for the preparation of magnetic nanoparticles and the seventh chapter describes individual experimental techniques for the study of magnetic nanoparticles. The final eighth chapter describes the applications of nanoparticles in biomedicine.

During the writing of this textbook, the chapters were prepared using the foreign-language specialist literature listed in the recommended reading list.

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Mária Kožurková

These university textbooks are intended for first-year master's degree students at the Faculty of Natural Sciences of UPJŠ in Košice. The scope and content of the works included in these scripts are primarily based on time and spatial constraints, taking into account the material demands of the tasks.

The aim of these scripts is to teach students basic microbiological techniques and to show them the importance of microorganisms in everyday life and their crucial role in nature. The exercises are designed to enhance students' technical skills and teach them to work according to safety principles.

The text is divided into 13 parts. Each part begins with an introduction to the theory related to the practice topic. The appendix includes a proposal for the preparation of protocols for individual exercises.

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Katarína Štrofeková

Cell Biophysics II is the one semester comprehensive course textbook for PhD students. It encompasses basic principles and mechanisms underlying cell physiology and biophysics with aims:

• General knowledge of the principles of cellular function, including membrane, cytoplasmic and nuclear roles in normal and abnormal conditions.
• In-depth understanding of the mechanisms underlying the cell functions at the molecular and subcellular level.
• Awareness of cell pathologies that lead to specific disease symptoms and phenotypes.
• The ability to apply learned principles to solve new problems (analysis & synthesis).

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Marek Bombara

The collection of exercises summarises and supplements the exercises realised at the Pavol Jozef Šafárik in Košice within the lecture course Elementary Particle Physics. The collection is intended for the master students of the Nuclear and Subnuclear Physics subject, but it could be beneficial also for other physics subjects or even for interdisciplinary study. 

The division of chapters roughly copies the order of lectures. At the beginning, students will briefly familiarize themselves with the basics of special relativity and its practical use in particle physics.

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Jozef Bednarčík (ed.)

Pavol Jozef Šafárik University in Košice under the auspices of Ministry of Education, Research, Development and Youth of the Slovak Republic, Ministry of Economy of the Slovak Republic and European X-Ray Free-Electron Laser Facility GmbH in Hamburg organizes School of XFEL and Synchrotron Radiation Users 2024 (SFEL 2024). The school is continuation of the Winter Schools of Synchrotron radiation held in 2011, 2013, 2014 and SFEL 2017, 2018, 2019 and 2022. The aim of the SFEL2024 school is to facilitate the growth of new Slovak research community of high expertise in high-efficiency RTG laser and synchrotron and neutron sources. The SFEL school is designed for efficient transfer of the rapidly developing know-how in these areas to young generation – researchers and university students. The next aim of the SFEL2024 is strengthening of personal connections between the local Slovak research community and forming scientific teams of XFEL users. Slovak research community thus can take advantage of the fact that Slovakia is a shareholder of European XFEL GmbH Company in Hamburg, but also makes more efficient use of other closely related scientific facilities, including ILL and ESRF in Grenoble and DESY in Hamburg.

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Rastislav Varga

The movement of domain walls in ferromagnetic materials is utilized in various magnetic devices for storing, processing, or transmitting signals and information. This mainly includes transformer cores, various sensors, memory devices (e.g., HDDs in PCs), as well as modern spintronic devices such as Racetrack memories, domain wall motion-based electronics, and so on.

This book is intended to serve as a textbook for advanced courses in the field of magnetic materials. It is primarily aimed at students interested in studying magnetic materials, as well as professionals from various fields who wish to understand the basics of domain structure and its changes. It is divided into nine chapters. The first chapter deals with a brief history of the study of domain structure in magnetic materials. The second chapter provides an introduction to the causes and manifestations of magnetic anisotropies. The third and fourth chapters are devoted to the causes of domain structure formation and domain walls. The fifth chapter discusses the structure of domain walls, their potential, and the critical field required for domain wall movement. The sixth chapter is dedicated to magnetization processes, one of which - domain wall movement - is discussed in detail in chapter 7. The eighth chapter contains a theoretical solution for domain wall movement. The final ninth chapter presents a modern method of domain wall movement induced by electric current.

The presented work assumes that the reader has at least basic knowledge in the field of magnetism. Otherwise, the author refers the reader to basic literature (e.g., [2.1 - 2.6]).

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Andrej Mock

The structure of the animal body is extremely varied. Each species has its distinctive morphological features, which bears as a testimony to long-term development and belonging to the developmental lineage. At the same time, the body has been tested for a long time by natural conditions, resulting in unique adaptations to the environment and life strategy. Despite this admirable variety - which includes both recent and fossil animals and which we have far from mapped – a comparison of body parts brings knowledge we can generalize: the main building principles, and boundaries within which phenotypic diversity is realized.

Comparative animal morphology today uses the latest methodological material and knowledge from other disciplines, from genetics, molecular biology and experimental embryology, through progressive imaging methods (e.g. electron microscopy, computer micro-tomography) and the possibilities of subsequent software processing of image material (measurement, staining, etc.) to the view of physics, chemistry, statics and geometry on the structures (to nanostructures) of the living body. Detailed knowledge of historical and contemporary conditions on Earth is an important interpretative context in the study of animal morphology. Surprisingly, the knowledge accumulated after centuries of research is now rapidly supplemented by new knowledge, and often the traditional knowledge is subsequently reinterpreted. Finally, and no less important, in studying animal (and human) morphology, we learn surprising knowledge about ourselves.

The author of the presented textbook had the ambition in a simplified form to introduce the reader, especially the student of biological studies, into a dynamic and fascinating scientific discipline, as the current comparative animal morphology is.

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Jana Špaková Raschmanová - Zuzana Kudličková - Kvetoslava Stanková

Organic chemistry plays a key role in our lives, from the pharmaceutical industry to the production of plastics and food additives. Additionally, it is essential in biochemistry, as it deals with the basic building blocks of living organisms, such as carbohydrates, lipids, proteins, and nucleic acids. One of the best ways to teach organic chemistry and increase students' interest in the subject is through conducting school experiments. This study material presents a collection of visually striking practical experiments in organic chemistry that will help students better understand the chemical processes and techniques used in the field. This electronic study material is supplemented with visual material, allowing students to verify the results of experiments and better understand the individual procedures. At the end of each section, there are questions to help assess the acquired knowledge and encourage deeper understanding of the experiments conducted.

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Kveta Markušová - Daniela Kladeková

Electrochemistry is the science that studies ionic systems and the processes or phenomena that occur at the interface between ionic systems and metals or semiconductors. At the current stage of development, electrochemistry can be divided into two main areas based on its focus. The first one - ionics - deals with the properties of ionic systems (solutions, melts, solid electrolytes). The second area - electrodeics - focuses on phenomena at the electrode/ionic system interface.

Both ionics and electrodeics investigate equilibrium and non-equilibrium phenomena and processes. Research into the properties of ionic systems under equilibrium conditions provides information and insights into the structure and composition of electrolyte solutions, melts, and solid electrolytes, while measurements under non-equilibrium conditions provide data on the electrical conductivity of ionic systems. In the field of electrodeics, the study of equilibria at the electrode/solution (or melt) interface is the domain of electrochemical thermodynamics. Measuring the rates of processes occurring at this phase interface and explaining the principles governing these processes fall under the scope of electrode process kinetics or electrochemical kinetics.

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Mariana Budovská

The aim of writing the university textbook "Selected Heterocyclic Compounds" was to create a study aid for students of the Organic Chemistry program, which provides essential information in a clear format for the subject of Heterocyclic Compounds. In selecting the content of the textbook, the goal was to present basic information about the chemistry of the most significant heterocycles. Given that the summary of chemical knowledge about heterocycles is vast, it was not possible to include all heterocyclic compounds in the content.

The intention was for readers to orient themselves in the field of heterocyclic compounds. Separate chapters included in the content address the nomenclature of heterocycles, basic chemical properties of individual heterocycles, their synthesis and reactions, the occurrence of heterocycles in nature, and their practical applications (medications, dyes, pesticides, detergents, etc.).

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Vladimír Zeleňák (ed.)

Proceedings of Abstracts of the Student Scientific Conference of the Faculty of Science, Pavol Jozef Šafárik University in Košice

A characteristic feature of education at high-quality universities — among which the Faculty of Science at Pavol Jozef Šafárik University (UPJŠ) in Košice proudly belongs — is the close connection between education and scientific research. Students gain knowledge in their field of study not only through theoretical coursework in individual disciplines, but also through active involvement in solving specific scientific tasks as part of research teams. This can occur during the development of final theses or through participation in the Student Research Assistant Program (ŠPVS), which was revitalized at the faculty in 2015.

The Student Scientific Conference (ŠVK) is one of the faculty’s traditional events, organized during the Faculty’s Science Days as part of Sciencefest. By its very nature, it fits seamlessly into the aforementioned framework of combining education with research, and it has long enjoyed great popularity and student interest. In 2016, the conference featured presentations by 125 students of the Faculty of Science at UPJŠ in Košice, across 16 thematic sections. This collection of abstracts provides an overview of the focus and goals of the student projects. We believe it will serve as inspiration for other potential participants of future conferences and will also be of interest to the broader public, offering additional insight into the faculty's activities.

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Soňa Király

The Book of Abstracts of The 9th International Conference on Novel Materials Fundamentals and Applications, NFA 2025, contains 46 contributions from the participants of this conference. This congress is primarily focused on novel materials, ranging from theory to practical applications, with the aim of demonstrating how fundamental discoveries can lead to innovative implementations. All contributions are inspiring and professionally prepared.

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Denisa Maceková-Monika Václavková-Marek Kvet-Ivana Sotáková
The Digilib Digital Library of Formative Assessment Tools – User Guide, Part A introduces the Digilib application as the key component of the library, designed to support the implementation of formative assessment in teaching at all levels of education. It explains the structure of the system, its modules, the principles of user roles, and the possibilities for working with the digital formative assessment tools. Particular attention is paid to the possibilities for creating, editing, and assigning the tools to students, as well as to providing personalised real-time feedback. The User Guide also explains how the Digilib application is interconnected with the affiliated applications Digiform and Digilib Images, which expand the possibilities for creating and visualising assessment tools. The guide is intended for teachers at all levels of education, student teachers, school administrators, and digital coordinators who are interested in the systematic use of the Digilib digital library to support the implementation of formative assessment, enhance the quality of the educational process, and foster the development of students’ self-assessment and reflective competences.
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Zuzana Kudličková(ed.)

Proceedings of Abstracts from the Scientific Conference with International Participation Organized on the Occasion of the 50th Anniversary of the Establishment of the Department of Organic Chemistry, Faculty of Science, Pavol Jozef Šafárik University in Košice, held on June 8–10, 2016 in Košice.

The Department of Organic Chemistry was established on February 1, 1966. From its inception, the department’s development prospects have been linked to high-quality scientific research focused on the synthesis of isothiocyanates and the products of their nucleophilic additions. In addition, studies were conducted on the use of cycloaddition, cyclocondensation, and photocyclization reactions of heterocumulenes in the synthesis of heterocycles.

Currently, research at the Department of Organic Chemistry is concentrated on stereoselective syntheses of iminosugars and γ-lactam-β-lactone antibiotics, total synthesis of natural compounds and their analogues possessing a sphingoid structure, research into the synthesis of indole alkaloids from the phytoalexin group, and the synthesis of acetylcholinesterase inhibitors based on acridine and coumarin derivatives.

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Ondrej Hutník

The concept of the integral is one of the most significant concepts in mathematics as a whole. In its most primitive form, it was already used by the ancient Greeks in the creation of Euclidean geometry. However, it was only after Descartes' work on analytical geometry in 1637 that mathematicians could begin to consider the integral as a subject of analysis. Descartes' work laid the groundwork for the discovery of infinitesimal calculus by Leibniz and Newton around 1665. At that time, a great dispute arose over the priority of this discovery, dividing scholars of Germany and England into two opposing camps, each favoring their own champion. Today, we know that Newton's work on fluxions and fluents was somewhat earlier, but Leibniz's notation and approach have gained more acceptance in the mathematical world, and the symbols ∫ ∫ and d d are still used today. A brief overview of the history of the integral will be presented in Chapter 1.

Today, there is a plethora of scripts, textbooks, and books dedicated to explaining the concept of the integral. Therefore, every potential author faces the initial question of whether to write another text on this topic. Our affirmative answer to this question was driven by the students' request to find the subject matter of a part of the winter semester of the second year presented in a coherent form. The second motivation is a slightly different approach to the topic. If we consider the methods typically used in solving problems and gaining routine with a certain integral, it mainly involves the Newton-Leibniz formula, and often there is little time left to compute the definite (Riemann) integral using its definition. Therefore, we included a discussion of the Newton integral in Chapter 2, which reflects this fact and is directly related to the indefinite integral, whose various calculation methods receive relatively much attention in the previous semester. Only after that, in Chapter 3, do we build the theory of the Riemann integral, present criteria for its existence, classes of integrable functions, basic properties, and finally its relationship with the Newton integral. Questions primarily concerning geometric applications are addressed in Chapter 4, and in the final chapter, we focus on extending the Riemann integral to unbounded functions and unbounded intervals.

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