Vybrané úlohy a výpočty z biochémie – metabolizmus

E-book

Zuzana Kudličková(ed.)

Proceedings of Abstracts from the Scientific Conference with International Participation Organized on the Occasion of the 50th Anniversary of the Establishment of the Department of Organic Chemistry, Faculty of Science, Pavol Jozef Šafárik University in Košice, held on June 8–10, 2016 in Košice.

The Department of Organic Chemistry was established on February 1, 1966. From its inception, the department’s development prospects have been linked to high-quality scientific research focused on the synthesis of isothiocyanates and the products of their nucleophilic additions. In addition, studies were conducted on the use of cycloaddition, cyclocondensation, and photocyclization reactions of heterocumulenes in the synthesis of heterocycles.

Currently, research at the Department of Organic Chemistry is concentrated on stereoselective syntheses of iminosugars and γ-lactam-β-lactone antibiotics, total synthesis of natural compounds and their analogues possessing a sphingoid structure, research into the synthesis of indole alkaloids from the phytoalexin group, and the synthesis of acetylcholinesterase inhibitors based on acridine and coumarin derivatives.

Download the e-book for free (pdf)

E-book

Andrea Morovská Turoňová

The discovery of radioactivity at the turn of the 19th and 20th centuries stimulated the rapid development of nuclear sciences. At the interface between nuclear physics and chemistry, disciplines such as radiochemistry, radiation chemistry and nuclear chemistry were formed.

The aim of the Nuclear Chemistry course which is taught at the PF UPJŠ is to provide basic knowledge, with an emphasis on the general value of the subject. It is important to make available the basics of various methods, techniques and their specifics in the application of nuclear phenomena in chemistry and related fields. Emphasis is also placed on the use of correct terminology, knowledge of the context of relationships and basic principles, supplemented by illustrative concrete cases.

The choice of material is rather difficult, but we count on additional monographs and textbooks to fill in the gaps of these teaching texts.

Download the e-book for free (pdf)

E-book

Karel Saksl

Solving crystal structures is the royal discipline of X-ray crystallography. Its primary task, with the exception of defects, is to describe the atomic structure of the motif that, by its repetition, fills the volume of the entire crystal or crystalline phase. This task is nowadays more or less routine for single-crystal X-ray diffraction, which can locate hundreds to thousands of non-hydrogen atoms in large unit cells. However, in real practice, we often have material available only in powder form instead of single crystals. Solving the atomic structure from its X-ray diffraction data is non-trivial, mainly because the three-dimensional diffraction space of a single crystal is reduced to one dimension by measuring a large number of randomly oriented microcrystals (crystallites). Therefore, the solution itself requires, in addition to proper measurement methodology, the selection of suitable tools, procedures, and strategies that, through optimization, will lead to the solution and refinement of the given crystalline phase. The current limit of this method is approximately 100 non-hydrogen atoms in the asymmetric part of the unit cell, which, however, is sufficient for most inorganic materials.

The goal of these educational texts is to provide students in the second and third levels of university studies with specific guidance on solving crystal structures from powder X-ray diffraction data. These scripts build upon my first monograph and require practical knowledge of its content. Similar to my previous monograph, I offer solved examples without a deep theoretical introduction, demonstrating procedures and strategies leading to the correct solution of crystalline phases using the freely available GSAS-II program. The examples are arranged from simpler to more complex, and the reader will find many useful pieces of information in the literature references as well as in the comments below the line. Part of these scripts are data intended for your individual practice of the described procedures. 

Karel Sakls

Download the e-book for free  (pdf)

E-book

Jozef Bednarčík

Crystallography deals with discerning the arrangement and bonding of atoms in crystalline solids. Almost immediately after their discovery, X-rays began to be used to study the internal structure of substances.

The first chapter of this textbook deals with the basic concepts of crystallography. At the beginning, crystalline solids are characterized. In the next section, the basic types of bonds and their characteristics are briefly presented. The main subject of this chapter is the interpretation of basic concepts such as symmetry operations, translational periodicity, grid, elementary cell. Spatial lattices and crystal systems are presented. At the end of this chapter, attention is paid to the description of individual types of defects in crystal structures. In the second chapter, the Bohr model of the hydrogen atom is presented. Individual quantum numbers and their meaning are given.

Next, energy levels and allowed transitions within an atom with multiple electrons are described. The second chapter concludes with the characterization of the basic absorption and emission processes. The third chapter is devoted to the production of X-ray radiation and its properties. Sources of X-ray radiation and a description of their operation are presented.

Interaction of X-ray radiation with matter, absorption and detection of X-ray radiation are the subject of the last part of this chapter.

Download the e-book for free (pdf)

E-book

Mária Vilková - Zuzana Kudličková - Ján Elečko

Organic chemistry is the chemistry of carbon. Organic compounds in the form of large molecules (macromolecules), such as nucleic acids, proteins, carbohydrates, and lipids are the basic elements of living organisms. This study material is created for non-chemistry students, especially students of biology. Most of these students have little or no knowledge of organic chemistry. Therefore, we proceed from the basic principles of organic chemistry to biochemistry.

The basic principles of organic chemistry and biochemistry are briefly summarized in individual chapters, but the main content consists of tasks for practising basic knowledge. To check the correctness of solving the tasks, the correct solutions are also given. The importance of this study material lies in the fact that students will get additional study material that they will use in studying the subject Basics of Chemistry.

Download the e-book for free (pdf)

E-book

Miroslava Martinková

This electronic material focuses on the subject of secondary metabolism and its products - secondary metabolites. The material gives an overview of the basic building blocks and construction mechanisms through which molecules can be synthesized in living organisms (plants). The processes of formation of the mentioned metabolites are explained using the basic mechanisms of organic reactions. Several of the secondary metabolites presented have a remarkable biological profile and are used as therapeutics or serve as lead compounds for the development of novel pharmacological agents. This electronic document is primarily intended for students of the Master's degree programme in Organic Chemistry as supporting material for the profile subject Chemistry of Natural Products.

Download e-book for free (pdf)

E-book

Zuzana Jurašeková

Úvod k praktikám k experimentálnym metódam biofyziky

The university textbook titled Laboratory Techniques and Calculations is designed for the first-year students of the bachelor's degree in Biophysics at the Institute of Physics, Faculty of Sciences, P. J. Šafárik University in Košice. The objective is to equip students with fundamental knowledge and practical skills for the work in a chemical laboratory. It is essential for addressing different biophysical issues and experiments that students will have to solve later. The textbook comprises three principal sections: a theoretical part focused on the calculations, a section dedicated to laboratory work, and the last part offers a brief introduction to spectroscopy. The theoretical part summarizes the basic definitions and equations related to the characterization and preparation of solutions and mixtures. The second, most comprehensive part provides guidance and suggestions for safe and efficient practices in a chemical laboratory. The primary focus is on the manipulation of chemical substances and the use of specific small laboratory instruments and equipment. The fundamental laboratory procedure guides for the selected laboratory works are also provided. As part of a short introduction to spectroscopy, students can become familiar with fundamental spectroscopic concepts and principles. UV-VIS absorption spectrophotometry receives special attention, along with a brief introduction to fluorescence. The textbook is supplemented by various practical and theoretical tasks, as well as numerous web links to further explanatory texts and videos.

Download the e-book for free (pdf)

E-publication
Soňa Király

The Book of Abstracts of the institutional conference Novel Trends in Chemistry, Research and Education 2025 consists of 88 contributions that reflect the current scientific direction and disciplinary diversity of chemical research at our faculty. The publication is divided into several chapters, including abstracts of 6 invited lectures, 4 plenary lectures, and thematically oriented sessions covering a broad spectrum of chemical disciplines. A total of 78 abstracts are included within the sections.

Download the e-book for free

 Ľubomír Panigaj - Peter Ľuptáčik 

(Náčrt systému a fylogenézy)

Učebný text je primárne určený pre študentov jednoodborového štúdia biológie a všeobecnej ekológie, ako aj odborom učiteľského štúdia v rôznych kombináciách s biológiou. Venuje sa v nich opisu jednotlivých skupín živočíchov, ich morfológiu a anatómiu ilustruje na obrazových materiáloch. K jednotlivým morfologickým a anatomickým štruktúram sa v texte nevyjadrujeme podrobnejšie, nakoľko text nadväzuje na predmet Porovnávacia morfológia živočíchov, kde na úrovni organológie boli tieto najvýznamnejšie štruktúry v rámci prednášok a cvičení detailne vysvetlené a opísané. Rozsah učebného textu nie je veľký, podávame v ňom základné minimum poznatkov, čo je podmienené jednak rozsahom predmetu, ktorý je len jednosemestrový, jednak tým, že ďalšie, špecializované predmety rozširujú spektrum poznatkov napr. na úrovni entomológie, hydrobiológie alebo pôdnej biológie. V zavere niektorých kapitol formulujeme niekoľko cvičných otázok, ktoré si študenti môžu na základe predchádzajúceho textu zodpovedať, s podobnými otázkami sa totiž môžu stretnúť na skúške alebo na štátniciach.

Autori

E-book

Ján Guniš - Ľubomír Šnajder

Prílohy

College scripts Programming in Python 1 are intended for future teachers of computer science. The content of the course is related to the teaching of programming in Scratch and is an introduction to text-based programming in Python.

Programming is introduced as a means of developing problem-solving skills. The first chapter is devoted to problem solving. The next 12 chapters sequentially introduce basic language constructions, data structures, and selected types of algorithms. Each of these chapters begins with an introduction to the problem. This section is primarily intended for self-study, to prepare students for the exercises. The following subchapter summarizes and completes the knowledge, and additional insights and approaches related to the chapter topic are presented. The chapters include a collection of exercises designed to practice and deepen knowledge and skills on the topic.

The final part of the chapter presents the solved problems. This section serves as a guide to solving the problems in the collection.

i

Download the e-book for free (pdf)

E-publication

Beáta Valkayed.
Ivana Slepáková-Lenka Maliničová a kol.

The EFFUSE Teacher's Guide is a practical educational material for primary and secondary school teachers who want to develop environmental awareness with their pupils through field-based learning. It is based on the concept of the EFFUSE project (‘Environment for the future by science education’), which aims to link science, research and education with environmental protection. The manual provides teachers with methodological support for planning and implementing outdoor activities aimed at observing and documenting organisms around the Laborec River and the Uh River. It contains instructions for working with real samples, basic biomonitoring procedures and offers the opportunity to participate in the creation of a virtual laboratory that mirrors the state of the local aquatic ecosystem. Through these activities, pupils will learn to understand the links between human activity and the state of the environment, while learning the basics of how scientists work in the fields of biology and ecology. The guide also motivates teachers to become agents of positive change, inspire the younger generation to be active and engage the community in conservation. It is a challenge and an opportunity to create a space for meaningful learning in line with current trends in environmental and digital education.

Download the e-book for free (pdf)

E-book

Janka Vrláková - Stanislav Vokál

Atomic and nuclear physics are relatively young scientific disciplines forming the final part of the general physics course at the Faculty of Physics of the Jagiellonian University. Their aim is to explain the nature of the basic physical properties of atoms, atomic nucleus and elementary particles.

This is also the content of the lectures and exercises ‘General Physics IV’ in the 2nd year of the Bachelor's degree in Physics at the Faculty of Natural Sciences (PF) of the P.J. Šafárik University (UPJŠ) in Košice. They are followed by optional lectures ‘Nuclear Radiation in the Environment’, ‘Introduction to the Physics of the Microworld’ in the 3rd year of the Bachelor's degree of single-discipline study of physics, or teacher study of physics in combination with another subject, and ‘Subnuclear Physics’ in the 1st year of the Master's degree of teacher study of physics in combination with another subject.

In the aforementioned lectures, the latest experimental findings on the structure and behaviour of the microworld are presented by means of physical theories and their subsequent experimental verification in experiments.

Download the e-book for free (pdf)

E-book

Michal Jaščur

This is a supporting text for the undergraduate students interested in quan- tum theory of magnetism. The text represents an introduction to various theoretical approaches used in this eld. It is an open material, in the sense that it will be supported by appropriate problems to be solved by student at seminars and also as a homework.

The text consists of four chapters that form closed themes of the in- troductory quantum theory of magnetism. In the rst part we explain the quantum origin of the magnetism illustrating the appearance of the ex- change interaction for the case of hydrogen molecule. The second chapter is devoted to the application of the Bogolyubov inequality to the Heisenberg model and it represents the part which is usually missing in the textbooks of magnetism. The third chapter deals with the standard spin wave-theory including the Bloch and Holstein-Primakoff a approach. Finally, we discuss the application of the Jordan-Wigner transformation to one-dimensional spin-1/2 XY model.

The primary ambition of this supportive text is to explain diverse math- ematical methods and their applications in the quantum theory of mag- netism. The text is written in the form which should be sufficient to de- velop the skills of the students up to the very high level. In fact, it is expected that students following this course will able to make their own original applications of the methods presented in this book.

Download the e-book for free (pdf)

E-book

Ondrej Krídlo - Gabriel Semanišin

For computer scientists, the constant challenge is to seek efficient algorithms and various technical and implementation possibilities to improve the computational complexity of currently known algorithms. Partial solutions are offered by approaches such as grid-based methods and parallelization of computation. Quantum computers represent a significant but still unfulfilled promise. From a theoretical perspective, probabilistic and approximation approaches provide very effective solutions, and these are the methods we aim to explore in detail.

These electronic university textbooks serve as supplementary materials for the course Approximation and Probabilistic Algorithms. They were developed from the authors' materials and contributions by Prof. RNDr. Viliam Geffert, DrSc., whom the authors thank for providing the manuscript. Acknowledgments also extend to RNDr. Ján Katrenič, PhD., who prepared the first set of exercises for the course, and Žaneta Semanišinová, who reviewed large portions of the text and contributed suggestions for its improvement.

Download the e-book for free (pdf)

E-book

Jozef Strečka- Katarína Karl’ová (eds.)

Zborník obsahuje program a abstrakty workshopu s názvom: 1st Workshop on Perspective Electron Spin Systems for Future Quantum Technologies, ktorý sa bude konať 28.-29. júna 2022 v Košiciach. Workshop je organizovaný Prírodovedeckou fakultou Pavla Jozefa Šafárika v Košiciach a Ústavom experimentálnej fyziky Slovenskej akadémie vied v Košiciach s finančnou podporou Agentúry na podporu výskumu a vývoja. Ústrednými témami konferencie budú súčasné problémy kvantovej fyziky - kvantovej teórie magnetizmu spinových a elektrónových štruktúr, exotických kvantových spinových stavov, kvantového previazania, kvantových fázových prechodov, topologického kvantového počítania a kvantového spracovania informácie. Účastníci workshopu budú prezentovať originálne pôvodné výsledky svojho výskumu, ktoré môžu zásadným spôsobom ovplyvniť vývoj budúcich kvantových technológií.   

Download the e-book for free (pdf)

E-book

Božena Mihalíková - Ján Ohriska

This text is intended for first-year students in 76-12-8 ‘General Education Teaching’ in combinations with mathematics. It is based on the authors' lectures and their more than ten years of experience in teaching this subject at the Faculty of Education of the University of Applied Sciences. When writing it, the authors tried to take into account the specificity of mathematics teaching studies.

The present teaching text was not written due to the lack of textbooks on mathematical analysis. The reason for writing it was the authors' findings that the students do not have sufficient experience in working with specialized literature from secondary school, the difficulties for many of them (especially in the first semesters) are caused by even a slightly different interpretation, not rarely also by a change in labeling, which makes them miss the essence of the studied problem. The authors of the text did not set out to be original. Their aim was to make such a selection of topics as is necessary for a future teacher of mathematics and to choose such a method of interpretation which, in their opinion, is suitable for first-year students.

A good mastery of the curriculum (expansion of the mathematical apparatus and the related possibilities of applying other methods of proof as well as the acquisition of the necessary numerical skills) presupposes the use of other literary sources (textbooks, collections of problems) according to the teacher's recommendation.

Download the e-book for free (pdf)