HOW TO STUDY AND NOT FORGET - Principles of brain-compatible learning

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Terézia Kisková - Stanislav Matéffy - Františka Horváthová

The laboratory rat (Rattus norvegicus) is one of the most commonly used experimental animals. It serves as a model organism for analyzing numerous biological processes and pathological mechanisms, such as cardiovascular diseases, metabolic disorders (e.g., lipid metabolism, diabetes mellitus), neurological and neuropsychiatric conditions (e.g., stroke, epilepsy, or Alzheimer's disease), neurobehavioral research, autoimmune diseases (e.g., arthritis), cancer, and renal diseases. It offers many unique advantages for modeling human diseases, testing drugs and natural substances, and studying responses to environmental factors. The size of the laboratory rat, compared to the mouse, creates ideal conditions for physiological manipulations. Additionally, rats are used in clinical toxicology to test chemical substances (Hedrich, 2000).

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Martina Chylová - Lívia Peštová

Učebné texty Psychológia v medicíne prezentujú základné poznatky o správaní sa a prežívaní človeka nielen v chorobe, približujú psychodiagnostické postupy a psychoterapeutickú liečbu pacientov. Podstatnou súčasťou práce je kapitola, ktorá pojednáva o lekárskej psychológii. Táto časť práce poukazuje na význam komunikácie a interakcie medzi lekárom a pacientom a nutnosť zohľadnenia významných vzťahových aspektov medzi nimi. Kapitola sa ďalej venuje psychosomatickému rozmeru vybraných chorôb v kontexte rôznych medicínskych odborov. Zároveň je analyzovaná psychologická problematika pacientov s telesným, zmyslovým postihnutím a duševne zaostalých osôb, záver učebnice predstavuje opis špecifík práce s detským pacientom. Pomocou týchto učebných textov si študenti medicíny majú osvojiť základné psychologické poznatky, získať vedomosti o efektívnej komunikácii s pacientmi, príbuznými a ostatným zdravotníckym personálom, tvorivo pristupovať k riešeniu problémov pri práci. Zároveň práca zdôrazňuje potrebu duševnej hygieny a starostlivosti o seba, ktorá je v práci lekára nevyhnutná.

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Iveta Cimbolákováa kol.

The premise “today’s research shapes the healthcare of tomorrow” expresses the importance of medical research and the reason for its pursuit. Scientific research and advances in biomedical sciences, as well as their application in medical practice and in the process of delivering healthcare, nevertheless bring new problems in the area of ethics.

Biomedical research itself requires the precise definition of hypotheses, which are tested both under laboratory conditions and on experimental animals. Although clinical studies on human subjects are expected to benefit individual participants and to advance fundamental biomedical knowledge, they also entail certain risks depending on the nature of the research. These risks must be minimized, and the experiment should be conducted freely while also taking place within specific measures to protect all involved-not only the test subjects, but also the researchers themselves.

The presented publication provides an overview of the general conditions and ethical principles of research involving laboratory animals and human subjects, the issue of professional and ethical assessment of projects, as well as fraud and the publication of results. At present, we are witnessing tremendous progress in molecular biological sciences, which brings ethical dilemmas also in the field of genetics. For this reason, one of the chapters is devoted to the latest findings in this area.

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Vladimíra Tomečková

Nature, as well as the human body, contains an abundant quantity of organic molecules. This textbook describes selected oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds of their reactions, which are important in the human body or are found in pharmaceutical active substances, poisons, foodstuffs and heat-treated food. The last part of the textbook describes the isomerism of organic compounds, which enables dynamic changes in the structure of molecules that have different properties. Nature is filled with different plants and animals and is the first laboratory to produce bioactive organic natural compounds. These compounds are compatible with human cells and are applicable as therapeutic medicine. There is an effort to reproduce natural molecules in chemical laboratories, but they cannot be as perfect as the natural ones. Synthetic molecules can serve as a model for multiple studies, but there still does not exist a magic panacea pill or a perfect copy of nature, for the treatment of various diseases. Knowledge about the regenerative and toxic effect of medicinal substances in dependence on their structure (type and number of substituents) is very important for the understanding of their role in modulation of health and disease in dependence on their concentration. Compounds can be used daily only in recommended doses (higher doses can be toxic), but still will not replace a healthy diet. People need a varied diet to be healthy, in which are all necessary nutrients, what Hippocrates demonstrated long ago “Let food be the medicine, and let medicine be the food.” This book is written for students who select bioorganic chemistry subject during the study of general medicine or dentistry as well as for motivated students who would like to practice their knowledge and wish to improve in this subject and for students who would like to learn simplified basic organic reactions with their future application in biochemistry. Learn the simple models mainly through creative simple instruction by using different colours, by repetition, practice by drawing of formulas by hand (at least three times) and memorization of common names of compounds and their reactions which have application in biochemistry. Thus, establishing simple educational methods how to distinguish organic molecules according to the colours of a functional group can promote universal learning for all students who thought that chemistry is a difficult subject, but hopefully they change their opinion after study of this book.

Keywords: organic molecules, oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds, chemical reactions, isomerism of organic compounds

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I. R. Mavlyanov - A. K. Ashirmetov - Z. I. Mavlyanov - G. J. Jarilkasinova

Need of carrying out a pharmacological genotyping for providing the individualized pharmacotherapy is shown in the monograph based on the analysis of own and literary data of the central link of drug pharmacokinetics– systems of cytochrome P-450, taking into account its genetic polymorphysm.
The monograph is intended for the clinical pharmacologists, geneticists and experts dealing with this problem.

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Magdaléna Hagovská - Alena Buková - Ľubomír Lachváč

Overweight as a risk factor for the development of civilization diseases and urogenital dysfunctions

Overweight and obesity represent a significant risk factor for the development of several diseases of civilisation, such as cardiovascular disease, type 2 diabetes mellitus and various forms of cancer. They also contribute significantly to urogenital dysfunctions such as urinary incontinence, overactive bladder and pelvic organ prolapse. Mechanisms that link excess weight to these dysfunctions include increased intra-abdominal pressure, hormonal changes, and chronic inflammatory processes that negatively affect the structure and function of the urogenital system. Prevention and treatment of overweight and obesity are therefore crucial not only in terms of reducing the risk of civilization diseases, but also in improving the quality of life through the prevention and treatment of urogenital dysfunctions.

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Ingrid Hodorová - Květuše Lovásová

The publication is a continuation of the already published university textbook"Ultrasound Anatomy 1" and fills the gap in the medical literary market concerning the ultrasound view of peripheral nerves and vessels of the limbs, and neck as well.

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Peter Berek

University scripts “Visceral pathology of vascular origin“analyze one of the most challenging vascular regions, the aorta and the visceral aortic branches, from the surgical perspective. The diagnostic and the treatment aneurysms of the abdominal aorta are dedicated to the first chapter. Early diagnostic and operative treatment is crucial in the treatment of ruptured aneurysms of the abdominal aorta. Shortening of the interval between the patient’s arrival with ruptured aneurysm of the abdominal aorta into the hospital and the beginning of the operation decreased the perioperative mortality. This shortening, together with the use of the cell savers, led to the dropping of perioperative mortality from 50% to 20%. The diagnostics and surgical treatment of the acute and chronic occlusion of the aorta and iliac arteries are analyzed in the second chapter. In this chapter, the focus is given to the aortobifemoral bypass as “the gold standard“ of the surgical therapy of aortoiliac atherosclerosis. The management of acute mesenteric ischemia is the content of the third chapter. Acute mesenteric ischemia is a severe condition with high mortality. The problem of acute mesenterial ischemia is a delayed diagnostic that is the reason for poor therapeutical outcomes of the disease. The possible imagine studies and operations used in treating acute mesenteric ischemia are brought in this chapter. Chronic mesenteric ischemia leads to cachexia. The diagnosis of chronic mesenterial ischemia is one of the most demanding, and surgical therapy used in the treatment of chronic mesenterial ischemia also belongs to the most challenging operations. Left-sided colon ischemia belongs to the severe complications of the aortoiliac reconstructions. Left-sided colon ischemia has a high mortality. In the prevention of the left-sided colon, ischemia is preserving at least one internal iliac artery. The complex diagnostics treatment of intraabdominal compressive syndromes as Dunbar syndróme, „Nutcracker“ syndróme a Wilkie syndróme, analyzed in the last chapter.

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Želmíra Macejová

Vysokoškolský učebný text: “Vybrané kapitoly z reumatológie pre študentov lekárskych fakúlt“je určený na  pregraduálne štúdium pre študentov lekárskych fakúlt v študijnom odbore: všeobecné lekárstvo a zubné lekárstvo v rámci predmetu interná medicína 4. Kapitoly uvedené v danom diele zahŕňajú základy reumatológie, ktoré postačuje pre absolventa LF UPJŠ, zároveň slúži aj pre pregraduálnu prípravu v nelekárskom študijnom odbore – fyzioterapia.  Uvedené informácie sú základom pre prípravu na tzv. postupovú skúšku v rámci spoločného internistického kmeňa a zároveň podkladom aj pre špecializačné štúdium v odboroch všeobecný lekár a fyziatricko- rehabilitačný lekár. Text je rozdelený na  tieto časti:  vyšetrovacie metódy v reumatológii, terapeutické výkony v reumatológii,  autoimunitné ochorenia v reumatológii, kryštálmi indukované artritídy, infekčné artritídy, nezápalové reumatické ochorenia a metabolické ochorenia kostí. V závere je obrazová príloha k jednotlivým nozologickým jednotkám, ktoré sú podrobne opísané v texte.    

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Silvia Mišíková

This learning text deals with heart rhythm disorders. The book is intended for medical students. There are in a simple way characterized bradycardic and tachycardic heart rhythm disorders. The script explains mechanism of arrhythmias, symptoms, diagnostics, and differential diagnostics and treatment. The greatest emphasis is focused on detection of the arrhythmias based on the surface ECG. All arrhythmias are explained by clinical ECG.

In conclusion, there is ECG quiz which consists of 27 clinical ECG records.

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Ingrid Hodorová - Květuše Lovásová

Publikácia je pokračovaním už vydanej vysokoškolskej učebnice "Ultrasonografická anatómia 1" a dopĺňa ďalšiu medzeru na medicínskom literárnom trhu, týkajúcu sa ultrasonografického pohľadu na periférne nervy a cievy končatín a krku.

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Jaroslav Majerník - Andrea Kačmariková

The university textbook "Databases in MS Access - accompanying texts for practical exercises" is intended for students of medical faculties, students of non-technical universities and all beginners in working with databases. It introduces the reader to the issue of database data processing and explains the basic principles that need to be known when creating relational databases. It is therefore suitable for those who have not yet worked with databases, or who have started thinking about managing their data using their own database.

However, even more "experienced" computer users can find useful information here. The university textbook is written in the way that its content can be mastered with basic knowledge of working with computers and programs running in the environment of MS Windows operating system.

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Kvetoslava Rimarová a kol.

Učebnica poskytuje komplexný a interdisciplinárny pohľad na problematiku humánnej výživy v kontexte verejného zdravotníctva, hygieny výživy a prevencie ochorení. Je koncipovaná ako základný aj rozširujúci študijný materiál pre študentov zdravotníckych, biomedicínskych a verejno-zdravotníckych odborov, ako aj pre odborníkov pôsobiacich v oblasti výživy, hygieny, potravinárstva a zdravotnej politiky. Publikácia systematicky pokrýva všetky kľúčové oblasti výživy človeka – od základných zložiek potravy (bielkoviny, sacharidy, tuky, vitamíny, minerálne látky), ich biologickej a energetickej hodnoty, cez odporúčané výživové dávky a tvorbu racionálneho jedálnička, až po hodnotenie nutričného stavu populácie. Osobitná pozornosť je venovaná antioxidantom, probiotikám a funkčným potravinám, ktoré predstavujú moderný a dynamicky sa rozvíjajúci segment výživovej vedy.

Učebnica reflektuje aktuálne trendy v stravovaní vrátane alternatívnych spôsobov výživy, prerušovaného pôstu, vysokoproteínových diét a konzumácie spracovaných a ultraprocesovaných potravín, pričom ich hodnotí z hľadiska vedeckých dôkazov, zdravotných prínosov aj rizík. Dôležitou súčasťou je problematika cudzorodých látok v potravinách, potravinárskych aditív a legislatívnych rámcov ich používania, ako aj význam pitnej vody, jej kvalita, úprava a zdravotné riziká spojené s kontamináciou. Publikácia sa venuje aj špecifickým oblastiam, ako sú alimentárne nákazy, výživa v jednotlivých vývinových obdobiach detí, nemocničné stravovanie a diétne systémy.

Praktickú hodnotu učebnice zvyšuje zaradenie metodicky spracovanej praktickej časti zameranej na mikrobiologické hodnotenie pokrmov rýchleho občerstvenia, založenej na reálnych dátach regionálnych úradov verejného zdravotníctva. Text je spracovaný prehľadne, s využitím tabuliek, obrázkov a aktuálnej odbornej literatúry, čo umožňuje čitateľovi nielen osvojenie teoretických poznatkov, ale aj ich aplikáciu v praxi. Učebnica predstavuje ucelený, moderný a vedecky podložený zdroj poznatkov o výžive ako jednom zo základných determinantov zdravia populácie.

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Lucia Bosáková - Zuzana Dankulincová - Daniela Fiľakovská

Publication called Scientific communication and management of research projects serves as background and teaching material. Its aim is to help university students and researchers develop competencies important for scientific work, such as scientific integrity, critical work with literary sources, management of research projects and scientific communication. Publication is divided into four parts.

The first part is focused on the preparation of a research project, where it is important to know the basic ethical principles applied in the research project, but also to be able to critically assess literary sources and process them. In the second part, it provides information on the preparation of research projects and their management, including their financing, from preparation and planning, through initialization to implementation, management, logistics, monitoring, evaluation and termination. The third part pays attention to the preparation, processing and presentation of scientific results in the form of a scientific article, presentation, poster or press release, thus covering not only a professional but also a lay audience.

The final fourth part provides information about communication with a scientific journal, whether it is the process of sending, revising an article up to its publication, or the process of assessing scientific work by scientific journal editors in the process of screening and peer review.

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Jozef Židzik - Terézia Hudáková - Martina Šemeláková - Ján Šalagovič

Methods in human genetics and molecular biology encompass various experimental, diagnostic and analytical techniques used to investigate the structure, function, expression, and regulation of genes, as well as general molecular processes in human cells. The university textbook Methods in Human Genetics and Molecular Biology provides a comprehensive overview of classical and modern experimental and analytical procedures. In fifteen chapters, it addresses methods such as PCR, RFLP, FISH, Western blot, DNA sequencing, DNA microarrays, molecular cloning, cytogenetic analysis, and forensic genetic analysis. The book is primarily intended as study material for the course of the same name taught in the 2nd year of study at the UPJŠ Faculty of Medicine, but it can also be used by all university students in the fields of biology, biotechnology, and related disciplines.

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Peter Fedoročko (eds.)

From June 14 to June 17, 2022, the 8th annual Spring School for Doctoral Students at Pavol Jozef Šafárik University in Košice will take place in Liptovský Ján. The scientific program of the spring school will comprise 3 plenary lectures by leading scientific experts and 1 workshop. Doctoral students will present their research papers in two sections: 22 doctoral students of Faculty of Public Administration, Faculty of Law and Faculty of Arts, and 26 doctoral students of Faculty of Medicine and Faculty of Science. The scientific programme of the spring school will also include a panel discussion with the management of Pavol Jozef Šafárik University in Košice.

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