Medical Biophysics: Practical Exercises

Tatiana Muchová

Medicína stále napreduje, je stále vo vývoji. Rádiologické zobrazovacie metódy prežívajú stále výrazný rozvoj vďaka prístrojovej technike, ktorá umožňuje zavádzať nové diagnostické metódy, ako sú USG vyšetrenia s kontrastnou látkou, špeciálne CT vyšetrenia, ku ktorým je potrebný viacradový CT prístroj – CT angiografia, CT enteroklýza, CT irigografia, CT virtuálna kolonoskopia. Magnetická rezonancia už v dnešnej dobe nie je nedostupné vyšetrenie, predstavuje výrazný pokrok v diagnostike.

Vďaka moderným prístrojom môžeme vykonávať rôzne intervenčné diagnostické aj terapeutické výkony, ako sú biopsie, drenáže...

Tieto učebné texty sú určené študentom lekárskych fakúlt, obsahuje základné poznatky z rádiológie.

Publikácia je rozdelená na všeobecnú a špeciálnu časť s následným delením podľa jednotlivých modalít a vyšetrovaných orgánov.

Rádiológia predstavuje prácu s obrazovou dokumentáciou, preto aj táto publikácia je obohatená veľkým počtom obrázkov z jednotlivých rádiologických vyšetrovacích modalít.

E-book

Dominika Jarčušková

The script deals with the issue of harmful alcohol use and its consequences on individuals’ cognitive abilities. The first part is devoted to the diagnosis of dependence syndrome and the assessment of risky drinking according to internationally recognized classifications (ICD, DSM). The following chapters explain the concept of cognition and its main components. Attention is also given to changes in cognitive functions during long-term alcohol abuse. The reader is introduced to the anatomical changes in the brain caused by alcohol. Damage to white matter and disorders of neurotransmission are described. Special focus is placed on diagnoses associated with alcohol use, such as Korsakoff syndrome, Wernicke’s encephalopathy, demyelinating disorders, and hepatic encephalopathy. Attention is also paid to the possibilities of diagnosing cognitive dysfunction. General screening tests such as MMSE or MoCA are presented. More specific tools, such as PHES or BEARNI, are described in greater detail. The script also points out the possibilities of pharmacological treatment. Non-pharmacological approaches, including cognitive remediation therapy and computer-based training, are also discussed. The conclusion is devoted to modern neuromodulation methods, in particular transcranial magnetic stimulation and transcranial direct current stimulation. This university textbook is primarily intended for students of medicine, psychology, and related health sciences.

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E-kniha

Silvia Farkašová Iannaccone a kol.

The history of ethics represents the search for a fundamental principle that would enable a person to distinguish between moral and immoral, good and evil, or right and wrong. The main issues are the motives, methods, and consequences of human actions.

The integrity of the medical profession emphasizes lifelong study and practice according to professional competence, and, last but not least, adherence to ethical principles and standards of medical ethics. Medical ethics and the related communication in the process of providing healthcare are becoming increasingly relevant topics. Communication between doctor and patient itself constitutes a very important part of the diagnostic process and treatment; it significantly contributes to the creation of a mutual relationship and, to a considerable extent, ensures patient cooperation.

The development of various information and network technologies allows for rapid communication even in medicine; however, a kind word and real contact with the patient, with an appropriate choice of verbal and nonverbal communication tools in personal contact, cannot be replaced by modern technology. The present era places demands on certain communication skills of the physician. Another ethical and legal issue is informed consent, which brings the patient’s active participation in the process of providing healthcare.

The presented publication provides basic information about medical ethics, communication in medicine in general, and communication skills in medical practice. Further chapters are devoted to the issue of informed consent, ethics, and the specifics of communication with selected groups of patients. We believe that this publication will clarify for the reader the basic ethical pillars and will be helpful for basic orientation in the issues of medical communication.

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Květuše Lovásová a kol. 

Despite the wide range of high quality textbooks offered on the Slovak market there is no publication with colorful pictures and schemes that can serve as an principal tool for practical and theoretical teaching of neuroanatomy for future psychologists in non-medical academic programmes of Arts and Science Faculties. Following new trends in methods of teaching, it is necessary to pay more attention to quality, depth, and effectiveness of education.

Such kind of illustrated textbook with the interesting graphic design should connect this important morphological subject and clinical medicine to understand the nervous system in the clinical context. This publication was created by using of original, new detailed pictures, and graphic schemes and was supplemented with a short clinical notes. It will be very helpfull to understand the details of neuroanatomical structures and brain regions.

We hope that originality and details of this book will find its application in studies of neuroanatomy for psychologists. 

E-book

Jana Raková et al.

The proposed university textbook focuses on topics related to nutrition and nutritional recommendations for patients with selected diseases.

The aim is to provide dietary recommendations for patients with cardiovascular diseases, obesity, metabolic syndrome, gastrointestinal and hepatobiliary disorders, and bone and joint diseases. An important part of the content includes nutrition in relation to cancer. Beneficial for the present time is also a chapter focused on food allergies and intolerances.

The publication highlights specific and targeted nutritional interventions as part of the treatment regimen, which is essential to know and follow in a patient's personal life.

PhDr. Jana Raková, PhD.
(on behalf of the authors' collective)

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 Eva Ďurovcová - Mária Mareková 

The presented textbook is intended for students of general medicine and should support their knowledge about indication and interpretation of basic biochemical tests. Clinical biochemistry continues to be one of the most rapidly advancing areas of laboratory medicine, which in line with using of modern technology more and more emphasizes the evidence-based medicine in order to improve diagnosis and monitoring of patients. Selected topics have an ambition to outline and explain the most common issues of biochemical diagnosis of in internal medicine. Individual chapters are devoted to disorders of water, electrolyte and acid-base balance, kidney and liver disease, diabetes mellitus, and biomarkers used in the diagnosis of cardiac necrosis and heart failure. Given the limited range, the textbook merely summarizes the basic knowledge that students have obtained during the study of other subjects, such as medical biochemistry, pathophysiology and internal medicine, and emphasis is given to laboratory diagnosis in accordance with the newer guidelines of professional societies. We hope that the textbook will be helpful in the study of clinical subjects and encourage students' interest in laboratory medicine.

Authors

E-book

Peter Fedoročko (eds.)

From June 14 to June 17, 2022, the 8th annual Spring School for Doctoral Students at Pavol Jozef Šafárik University in Košice will take place in Liptovský Ján. The scientific program of the spring school will comprise 3 plenary lectures by leading scientific experts and 1 workshop. Doctoral students will present their research papers in two sections: 22 doctoral students of Faculty of Public Administration, Faculty of Law and Faculty of Arts, and 26 doctoral students of Faculty of Medicine and Faculty of Science. The scientific programme of the spring school will also include a panel discussion with the management of Pavol Jozef Šafárik University in Košice.

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E-book

Emil Fraenkel  Martin Kaško Jana Deptová

The authors address the current view on the pathophysiology of type 2 diabetes mellitus, while the following sections are devoted to classification, clinical presentation, diagnosis, and epidemiology of diabetes. The work provides insights into outpatient therapeutic management of patients by specialists and during hospitalisation for acute complications of diabetes, taking into account the latest recommendations from the last two years. Separate chapters are devoted to the management of associated and concomitant diseases, such as hypertension, dyslipidemia, or complications of diabetes, including cardiovascular complications, neuropathy, nephropathy, and ocular complications. The work also discusses the issue of diabetes mellitus in pregnancy, including gestational diabetes mellitus. A special chapter, written by a co-author, is devoted to the issue of osteoporosis in patients with diabetes mellitus.

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E-book

Jaroslava Kopčáková

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E-book

Ladislav Kočan - Dušan Rybár - Róbert Rapčan

The autonomic nervous system is a vital component of the peripheral nervous system, responsible for maintaining homeostasis and regulating internal processes within the body. Unlike the voluntary control exerted by the central nervous system, the autonomic nervous system operates involuntarily, innervating smooth organs, vessels, skin glands, and even exerting some influence over skeletal muscles in connection with vegetative functions such as breathing, digestion, and the urinary and gonadal systems. Its impact extends crucially to the cardiac muscles of the heart and plays a significant role in endocrine and metabolic functions, thermoregulation, as well as emotional and behavioral responses, including adaptive reactions to stressors.

The aim of this publication is to provide a comprehensive and objective exploration of the anatomical and physiological intricacies of the autonomic nervous system, offering insights into its clinical applications. Within these pages, we meticulously delineate various interventional therapeutic procedures tailored to specific diagnoses related to the autonomic nervous system, aligning each intervention with the anatomical framework of the autonomic system. The efficacy of these procedures is evaluated based on the level of evidence, as per the current recommendations of Evidence-Based Medicine.

This publication is primarily crafted for fifth and sixth-year medical students and medical professionals specializing in anesthesiology, intensive care, and pain medicine. It serves as a valuable resource for gaining a deeper understanding of autonomic nervous system function and its clinical implications, facilitating informed decision-making in clinical practice.

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E-book

Magdaléna Hagovská - Alena Buková - Ľubomír Lachváč

Overweight as a risk factor for the development of civilization diseases and urogenital dysfunctions

Overweight and obesity represent a significant risk factor for the development of several diseases of civilisation, such as cardiovascular disease, type 2 diabetes mellitus and various forms of cancer. They also contribute significantly to urogenital dysfunctions such as urinary incontinence, overactive bladder and pelvic organ prolapse. Mechanisms that link excess weight to these dysfunctions include increased intra-abdominal pressure, hormonal changes, and chronic inflammatory processes that negatively affect the structure and function of the urogenital system. Prevention and treatment of overweight and obesity are therefore crucial not only in terms of reducing the risk of civilization diseases, but also in improving the quality of life through the prevention and treatment of urogenital dysfunctions.

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E-book

Sylvia Dražilová - Laura Gombošová - Martin Janičko - Ľubomír Skladaný - Eduard Veseliny

University textbooks are focused on undergraduate medical students and young doctors engaged in specialized training in gastroenterology, hepatology, and internal medicine.

The authors aimed to somewhat replace the lack of a concise and straightforward textbook on gastroenterology and hepatology for medical students, while also providing specific, directly applicable information for young doctors in inpatient departments caring for these patients.

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E-book

Iveta Domoráková - Štefan Tóth - Zuzana Fagová - Kristína Čurgali - Viera Eliášová - Alexandra Kunová - Monika Holodová

The peer-reviewed textbook and microscopic atlas is aimed at understanding the basic microscopic structure of cells and tissues in a light microscope. Texts in the textbook are complemented by a rich set of histologic micrographs with basic and specific staining techniques.

All histologic micrographs were prepared by the author's team at the Department of Histology and Embryology, Faculty of Medicine, UPJŠ.

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Vladimíra Tomečková

Nature, as well as the human body, contains an abundant quantity of organic molecules. This textbook describes selected oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds of their reactions, which are important in the human body or are found in pharmaceutical active substances, poisons, foodstuffs and heat-treated food. The last part of the textbook describes the isomerism of organic compounds, which enables dynamic changes in the structure of molecules that have different properties. Nature is filled with different plants and animals and is the first laboratory to produce bioactive organic natural compounds. These compounds are compatible with human cells and are applicable as therapeutic medicine. There is an effort to reproduce natural molecules in chemical laboratories, but they cannot be as perfect as the natural ones. Synthetic molecules can serve as a model for multiple studies, but there still does not exist a magic panacea pill or a perfect copy of nature, for the treatment of various diseases. Knowledge about the regenerative and toxic effect of medicinal substances in dependence on their structure (type and number of substituents) is very important for the understanding of their role in modulation of health and disease in dependence on their concentration. Compounds can be used daily only in recommended doses (higher doses can be toxic), but still will not replace a healthy diet. People need a varied diet to be healthy, in which are all necessary nutrients, what Hippocrates demonstrated long ago “Let food be the medicine, and let medicine be the food.” This book is written for students who select bioorganic chemistry subject during the study of general medicine or dentistry as well as for motivated students who would like to practice their knowledge and wish to improve in this subject and for students who would like to learn simplified basic organic reactions with their future application in biochemistry. Learn the simple models mainly through creative simple instruction by using different colours, by repetition, practice by drawing of formulas by hand (at least three times) and memorization of common names of compounds and their reactions which have application in biochemistry. Thus, establishing simple educational methods how to distinguish organic molecules according to the colours of a functional group can promote universal learning for all students who thought that chemistry is a difficult subject, but hopefully they change their opinion after study of this book.

Keywords: organic molecules, oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds, chemical reactions, isomerism of organic compounds

E-publikácia

Silvia Farkašová Iannaccone

Forensic medicine is a fundamental medical discipline that deals with determining the cause of death in cases of violent and non-violent deaths, as well as investigating and assessing the effects of violence on the human body, including in cases involving living persons. This textbook provides a comprehensive and complex overview of the basic tasks and theoretical knowledge of forensic medicine. Its aim is to provide a theoretical basis in the form of images of morphological autopsy findings for the study of the compulsory subject Forensic Medicine and Medical Law in the study programs General Medicine and Dentistry. The author emphasizes the need to know the basics of forensic medicine in every medical field and to take a multidisciplinary approach when clarifying medical-legal issues.

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Miroslav Gajdoš - Igor J.Šulla a kol. 

Učebnica pre lekárov a študentov všeobecného lekárstva

Medicína je neprestajne sa vyvíjajúca vedná disciplína. Základný výskum v spojení s klinickou praxou rozširujú súčasné vedomosti, čo sa veľmi výrazne prejavuje aj v neurovedách, v praktickej podobe hlavne v neurofyziológii, neurofarmakológii, neurológii, diagnostickej aj intervenčnej neurorádiológii a v neurochirurgii. V priebehu ostatných troch desaťročí neurovedy prekonali pozoruhodný vývoj. Podnietili ho potreby praxe a umožnilo využitie poznatkov biológie, chémie, biochémie, aplikovanej matematiky, výpočtovej techniky a fyzikálnych objavov realizovaných v moderných prístrojoch i liečebných postupoch. To všetko podstatne uľahčilo, spresnilo a urýchlilo diagnostiku ochorení nervového systému, umožnilo relatívne bezpečné chirurgické zásahy na štruktúrach v minulosti nedostupných a otvorilo nové perspektívy, hlavne v oblasti reparácie poškodených tkanív, respektíve ich funkcií autotransplantáciou kmeňových/progenitorových buniek, terapeutickými zásahmi na genómovej, prípadne proteómovej úrovni. Ako vysokoškolskí učitelia sa každodenne stretávame nielen s mimoriadnym záujmom študentov i zdravotníckych pracovníkov o nové poznatky, ale aj s určitou neistotou pri posudzovaní možností, ktoré jednotlivé disciplíny patriace do skupiny neurovied ponúkajú. Jednou z príčin spomenutého javu je pravdepodobne časový faktor, keď najnovšie poznatky ešte nestačili preniknúť do odbornej literatúry, alebo v nej nie sú dostatočne zdôraznené. Druhou príčinou môže byť pomerne malá skúsenosť s niektorými ochoreniami nervového systému, ktoré sa síce vyskytujú zriedkavejšie, ale ich následky sú závažné. Cieľ, ktorý sme sledovali napísaním tejto učebnice, bolo aspoň čiastočne odstrániť spomenuté nedostatky všetkých odborných publikácií.

Počas prípravy rukopisu sme sa snažili, aby terapeutické postupy, názvy liekov a ich dávkovanie boli v súlade s najnovšími poznatkami vedy a klinickej praxe. Oprávnene však môžeme predpokladať, že budúce objavy zmenia súčasný pohľad na problematiku diagnostiky aj liečby ochorení nervového systému.

Vysokoškolská učebnica je určená študentom všeobecného lekárstva UPJŠ Lekárskej fakulty v Košiciach a lekárom, zameraným hlavne na všeobecné lekárstvo.

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