Získané demyelinizačné ochorenia centrálneho nervového systému-diferenciálna diagnostika

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Dominik Šafčák

Both clinical and radiation oncology are the most developing parts of medicine. Regardless of the physician´s specialization, all of them will have to face subjects with cancer in their daily clinical practice. It includes not only the treatment itself, but also obtaining the diagnosis, but also differential diagnosis and treatment of different adverse events caused by oncological treatment. This publication provides basic data about tumor characteristics necessary for oncologists to determine the final stage and choose the best treatment strategy. In addition, explains the basic oncological terms, forms of therapy, and provides information about treatment timing, combination strategies and expected outcomes. It explains main endpoints of clinical trials performed in oncology to understand them.  In the second part this publication describes mechanism of action of all treatment modalities used in clinical oncology, provides information about potential side effects and basic knowledge how to deal with them. The last chapter is focused on palliative care, how to relieve symptoms of dying patient and how to deal with cancer-related pain. 

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Eva Ďurovcová - Mária Mareková

Clinical Biochemistry - selected chapters - MEFANET >>> 

After 7 years, we finally reworked the textbook on the subject of clinical biochemistry at UPJŠ FM in Košice. We have innovated information in accordance with recommendations of professional medical societies and added new chapters. As the scope of the subject is limited, the textbook does not cover all issues of biochemical diagnostics. It focuses on disorders of water-ion and acid-base balance disorders, and basic laboratory diagnostics of diseases of selected organs.

The textbook of clinical biochemistry has the ambition to become a practical aid for senior medical students and beginning doctors in the study of laboratory medicine. It should make it easier for them to orientate themselves in routinely used clinical-biochemical examinations and could form a springboard for a more detailed studying of laboratory methods and their use in diagnostic and monitoring algorithms.
Like any medical discipline, clinical biochemistry is evolving rapidly and gradually integrating with other areas of laboratory medicine. New diagnostic methods penetrate deeper into the essence of the biochemical mechanisms of the human body, and "omic" methods are gaining ground. It is almost sure that in a few years, laboratory examination looks quite different from today. If this publication quite hypothetically reaches its next edition, many chapters will need to updated, and new chapters written following the up-to-date status.
Authors thanks to their colleagues and reviewers for their professional comments and constructive criticism of the text - prof. Jaroslav Racek, MD, DrSc. from FM UK in Pilsen.
Authors thanks very kindly too prof. MUDr. Dušan Dobrota, CSc. (JFM UK Martin) and doc. MVDr. Zuzana Kostecká, PhD. (UVMP, Košice), who read and wrote review of this textbook.

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Jozef Radoňak a kol.

Skriptá chirurgická propedeutika predstavujú učebné texty prinášajúce pohl'ad do histórie chirurgie cez všeobecne platné princípy chirurgie, moderné diagnostické a terapeutické metó­dy. Patričná pozornost' sa venuje základom chirurgickej onkológie, úrazovej chirurgie, anesteziológie a resuscitácie ako aj liečbe krvácania, infekcie, šoku či transplantáciám. Súčas­ťou textu sú aj kapitoly z vojnovej chirurgie.

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Miriam Kozárová

The publication "News in Diabetology and Lipidology" focuses on extremely relevant topics in diabetology and lipidology, reflecting the state of these issues in light of the recommendations from professional societies from 2019. In diabetology, it primarily addresses the intensification of antidiabetic treatment using modern drug classes—specifically, incretin enhancers and sodium-glucose cotransporter-2 (SGLT-2) inhibitors (gliflozins). Few medical fields have experienced such a development of new pharmacological options as diabetology has in the last two decades. While pharmacotherapy for type 2 diabetes (DM2) was limited to the use of biguanides, sulfonylurea derivatives, and insulin throughout the second half of the last century, recent years have introduced entirely new groups of oral antidiabetics with cardio- and nephroprotective effects. In lipidology, it pertains to the new recommendations from the European Atherosclerosis Society (EAS) with new treatment goals for serum lipids and lipoproteins, including the use of biological therapies.

This textbook is primarily intended for medical students in doctoral studies and doctoral candidates, as well as for physicians preparing for specialization exams in internal medicine, endocrinology, diabetology, metabolic disorders and nutrition, as well as cardiology and angiology. I believe that readers will find information in this publication that will aid them in their studies and translate into their daily clinical practice.

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Zuzana Dankulincová a kol.

The scientific monograph is the output of the Care4Youth project, which aimed to map the current system of care for adolescents with emotional and behavioral problems (EBP) in Slovakia. It captures what the care system is and what its possible shortcomings are from the perspective of all those affected (adolescents with problems, their parents, care providers and other institutions involved).

It also looks at the trajectory of adolescents with EBP in the care system, i.e. when and how adolescents with problems enter and leave the care system, or pass from one type of care to another and what impact different trajectories have on them.

Last but not least, the aim of the monograph was to provide expert information on what are the risk and protective factors that will affect their success in the care system or, conversely, that threaten them. All this in order to support the proposal for improvements in the care system that would benefit all stakeholders.

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Želmíra Macejová

Vysokoškolský učebný text: “Vybrané kapitoly z reumatológie pre študentov lekárskych fakúlt“je určený na  pregraduálne štúdium pre študentov lekárskych fakúlt v študijnom odbore: všeobecné lekárstvo a zubné lekárstvo v rámci predmetu interná medicína 4. Kapitoly uvedené v danom diele zahŕňajú základy reumatológie, ktoré postačuje pre absolventa LF UPJŠ, zároveň slúži aj pre pregraduálnu prípravu v nelekárskom študijnom odbore – fyzioterapia.  Uvedené informácie sú základom pre prípravu na tzv. postupovú skúšku v rámci spoločného internistického kmeňa a zároveň podkladom aj pre špecializačné štúdium v odboroch všeobecný lekár a fyziatricko- rehabilitačný lekár. Text je rozdelený na  tieto časti:  vyšetrovacie metódy v reumatológii, terapeutické výkony v reumatológii,  autoimunitné ochorenia v reumatológii, kryštálmi indukované artritídy, infekčné artritídy, nezápalové reumatické ochorenia a metabolické ochorenia kostí. V závere je obrazová príloha k jednotlivým nozologickým jednotkám, ktoré sú podrobne opísané v texte.    

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Štefan Tóth

Dyslipidemia is one of the main risk factors for the development of cardiovascular diseases. In recent years, extensive research has been conducted, leading to changes in therapeutic recommendations for dyslipidemia. These scripts aim to provide readers in the introductory chapters with information on the basic management of patients with dyslipidemia, procedures, target levels, and available medications and their combinations for achieving target levels, focusing on the practical aspect of dyslipidemia treatment. In the special section of the script, an overview is provided of the basic characteristics, studies of individual available hypolipemics, as well as hypolipemics that are not yet on our market or are still in the stage of clinical trials

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Michal Legiňa kol.

Progress in biology and medicine has always been significantly related to advances in physics. Not only has physics supplied instruments and methods of measurement that have led to many discoveries in physiology and medicine, but methods of physical research have changed many of the older approaches to the biologic sciences. Such circumstances have even led to development of a new scientific field: biophysics, which uses to a great extent physical instrumentation procedures applied to an experimental system. Because any instrument is an additional factor in any experimental system, it may affect the data. To interpret physical data on biological material correctly then, it is necessary to consider the characteristics of instrument response.

A practical course enables a student to acquire some skills, experience and methodological knowledge for performance of experiments and evaluation of measured data. Due to the fast development of instrumentation technology, it is not possible to teach every operation and procedure upon instruments we may use in a future. Besides the basic physical principles, the aim of a practical course is to point out some general rules and skills for instrument operation and for the interpretation of the measured values derived from such operation.

There are two kinds of lessons in practical courses. The first one focuses on laboratory measurements of some important physical quantities and the evaluation of the measured data. These measured quantities are components of the subject “medical biophysics” or of the phenomena studied. Experience provided in managing various scales and tables, as well as in the construction of tables and graphs is substantial. Lessons also enable students to repeat and to strengthen their knowledge of secondary school physics, which is useful for understanding of many phenomena studied in medical biophysics. The second kind of lesson provides experience with some of the diagnostic and therapeutic medical instruments, which can be seen in practical medicine.

The understanding of basic physical principles of corresponding instruments is both recommended and demanded. Theoretical preparation is not only an appropriate condition for the practical managing of the whole lesson, but also helps to avoid injury. This textbook, therefore, intends to help students in preparing for both the practical lessons and the final exam.

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Mária Pallayová - Štefan Kujaník

The “Textbook of Practical Physiology, Part I - Cardiovascular Physiology” by Mária Pallayová and Štefan Kujaník is a practical textbook of Human Physiology intended for English speaking medical students from general medicine and dentistry curricula.

The textbook covers basic principles in cardiovascular physiology and methods of the cardiovascular examination. Adequate knowledge of the cardiovascular physiology is important for the understanding of cardiovascular system function, as well as for the diagnosis and proper treatment of cardiovascular and other diseases. The practical tasks are constructed to facilitate knowledge acquisition and encourage students to develop practical skills, for instance the ability to follow experimental protocols, to work as part of a team, and to interpret data.

The textbook is written in English and comprises 91 pages in B5 format, grouped into twelve chapters. Each chapter is divided into six sections (Introduction, Principle, Importance, Materials, Procedure, and Protocol) to facilitate students’ understanding of the topics and assist them with preparation of the laboratory reports. The text is accompanied by explanatory figures, graphs, and tables that contribute to the learning experience.

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Adriana Boleková - Natália Hvizdošová (eds.)

Košický morfologický deň je každoročné májové stretnutie morfológov, ktorého sa zúčastňujú najmä košické morfologické pracoviská. Pri tejto príležitosti sa pravidelne vydáva zborník vedeckých prác. Tohoročný zborník je vydaný pri príležitosti 27. košického morfologického dňa. V zborníku autori prezentujú výsledky svojej vedecko-výskumnej a pedagogickej činnosti, ktoré majú charakter teoretických prehľadových štúdií a výskumných prác.

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Andrea Madarasová Gecková - Daniela Husárová a kol.

The aim of this publication is to present the latest findings of the international study Health Behavior in School-aged Children (HBSC), regarding the health and health-related behavior of school-aged children in Slovakia.After four years, it again brings information on various topics covering physical and mental health, nutritional behavior, leisure-time activities, use of psychoactive substances, within social environment of school-aged children, including family, school and peers. The publication also presents newfindings connected to objectively measured physical fitness of these children. Finally, data about school-aged children with special educational needs are also presented.The findings play an important role in understanding the needs of the new generation of adolescents and are an important source of information for all those who work with them, not only professionals but also parents.Last but not least, they are also beneficial for all stakeholders and institutions who participate in the preparing of policies and strategies focused on supporting the health of school-aged children.

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Marek Šoltés - Jozef Radoňak

Laparoscopic surgery today represents the standard and, in many respects, a preferred modality of surgical treatment. The dynamics of its global expansion, enabled by advancements in biomedical technologies and the development of global information and communication channels, is unprecedented in the history of surgery. Currently, there is virtually no abdominal operation that is not performed laparoscopically, with laparoscopic procedures often being the method of choice.

Despite—or perhaps because of—the unprecedentedly rapid penetration of laparoscopic surgeries into everyday surgical practice, universally accepted technical standards are still lacking in many respects. The high variability of procedural approaches within individual laparoscopic operations stems more from the traditions of specific workplaces than from evidence-based medicine. This situation is further influenced by the development of new and revived concepts such as mini-laparoscopy, SILS (Single Incision Laparoscopic Surgery), NOTES (Natural Orifice Transluminal Endoscopic Surgery), and their hybrid combinations with classical laparoscopy.

The aim of this monograph is to draw the attention of the professional community back to the fundamental principles of laparoscopic surgery, which should serve as a foundation for the effective and safe performance of laparoscopic operations, as well as a basis for a critical stance towards fashionable innovative trends.

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František Sabola kol.

Although we are not really sure if “Love is coming from the Heart” and nor we know where “the Residence of Soul” is, we are still overwhelmed by its unprecedented effort to keep us alive. Our lives are nowadays fulfilled with enormous chances to satisfy our needs and wishes. Hand in hand is changing our way of life, the intake of calories is growing and the amount of physical activity decreasing. We live longer and maybe happier but our hearts
and vessels are like mirrors showing us how we live. Diseases of the Heart and vessels have become the number one cause of death in highly developed countries including our homeland.
Prevention of cardiovascular diseases has become and an important social and health care system issue. The knowledge requirement of basic principles of cardiology and heart surgery is increasing. Without an understanding of basic principles a good clinical practice is hardly possible.
Together with my Colleagues of Heart surgery department of VÚSCH and LF UPJŠ we prepared this short overview of basic knowledge about surgery of the human heart. We hope that reading it will be more an adventure than a painful journey. If you find some answers to your unanswered questions our effort was not a waste of time.

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Lucia Dimunová - Jana Michalková - Gabriela Štefková - Mária Zamboriová

Following innovative trends in university education, this academic textbook offers guidance to update and make the educational process more attractive for all healthcare professions. It applies critical thinking and strategic method of concept mapping in teaching, which are suitable tools for the facilitator and the educant to achieve the desired goal. Critical thinking is an essential academic skill upon which other knowledge and intellectual virtues can be built. It is also an essential equipment for every graduate of the healthcare profession.

The textbook is complemented by a chapter focusing on methods for structural and formative assessment of learning outcomes. The publication is also enriched with sample digital concept maps of which cognitive content can be edited and graphically modified.

The aim of this academic textbook is to present a way of acquiring knowledge through critical thinking using concept mapping as a method, with the final goal of implementing the acquired knowledge into everyday practice.

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Tatiana Muchová

Medicína stále napreduje, je stále vo vývoji. Rádiologické zobrazovacie metódy prežívajú stále výrazný rozvoj vďaka prístrojovej technike, ktorá umožňuje zavádzať nové diagnostické metódy, ako sú USG vyšetrenia s kontrastnou látkou, špeciálne CT vyšetrenia, ku ktorým je potrebný viacradový CT prístroj – CT angiografia, CT enteroklýza, CT irigografia, CT virtuálna kolonoskopia. Magnetická rezonancia už v dnešnej dobe nie je nedostupné vyšetrenie, predstavuje výrazný pokrok v diagnostike.

Vďaka moderným prístrojom môžeme vykonávať rôzne intervenčné diagnostické aj terapeutické výkony, ako sú biopsie, drenáže...

Tieto učebné texty sú určené študentom lekárskych fakúlt, obsahuje základné poznatky z rádiológie.

Publikácia je rozdelená na všeobecnú a špeciálnu časť s následným delením podľa jednotlivých modalít a vyšetrovaných orgánov.

Rádiológia predstavuje prácu s obrazovou dokumentáciou, preto aj táto publikácia je obohatená veľkým počtom obrázkov z jednotlivých rádiologických vyšetrovacích modalít.

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Magdaléna Hagovská - Alena Buková - Ľubomír Lachváč

Overweight as a risk factor for the development of civilization diseases and urogenital dysfunctions

Overweight and obesity represent a significant risk factor for the development of several diseases of civilisation, such as cardiovascular disease, type 2 diabetes mellitus and various forms of cancer. They also contribute significantly to urogenital dysfunctions such as urinary incontinence, overactive bladder and pelvic organ prolapse. Mechanisms that link excess weight to these dysfunctions include increased intra-abdominal pressure, hormonal changes, and chronic inflammatory processes that negatively affect the structure and function of the urogenital system. Prevention and treatment of overweight and obesity are therefore crucial not only in terms of reducing the risk of civilization diseases, but also in improving the quality of life through the prevention and treatment of urogenital dysfunctions.

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