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CYTOCHROME P-450: genetic and population aspects

CYTOCHROME P-450: genetic and population aspects

E-book

E-book

I. R. MavlyanovA. K. AshirmetovZ. I. MavlyanovG. J. Jarilkasinova

Need of carrying out a pharmacological genotyping for providing the individualized pharmacotherapy is shown in the monograph based on the analysis of own and literary data of the central link of drug pharmacokinetics– systems of cytochrome P-450, taking into account its genetic polymorphysm.
The monograph is intended for the clinical pharmacologists, geneticists and experts dealing with this problem.

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Emigration intentions and risk behaviour among university students

Emigration intentions and risk behaviour among...

E-book

E-book

Oľga OrosováBeáta Gajdošová (eds.)

This publication considers social, economic, political, and psychological indicators of emigration behavior and emigration intentions as appropriate predictors of future behavior.

Theories of motivation and theories of behavioral intentions and their effectiveness are popular in migration research. On the other hand, the Health Belief Model and its adaptation in the research of emigration intentions bring a relatively new and perspective view on this topic.

According to the results presented in this publication, the factors that attract students to emigration (pull factors) are language skills and career opportunities abroad, the desire for change and new experiences, perceived feasibility of emigration, and self-efficacy.

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Elementary organic molecules in biochemistry

Elementary organic molecules in biochemistry

€22.00
Availability: 45 In Stock

Vladimíra Tomečková

Nature, as well as the human body, contains an abundant quantity of organic molecules. This textbook describes selected oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds of their reactions, which are important in the human body or are found in pharmaceutical active substances, poisons, foodstuffs and heat-treated food. The last part of the textbook describes the isomerism of organic compounds, which enables dynamic changes in the structure of molecules that have different properties. Nature is filled with different plants and animals and is the first laboratory to produce bioactive organic natural compounds. These compounds are compatible with human cells and are applicable as therapeutic medicine. There is an effort to reproduce natural molecules in chemical laboratories, but they cannot be as perfect as the natural ones. Synthetic molecules can serve as a model for multiple studies, but there still does not exist a magic panacea pill or a perfect copy of nature, for the treatment of various diseases. Knowledge about the regenerative and toxic effect of medicinal substances in dependence on their structure (type and number of substituents) is very important for the understanding of their role in modulation of health and disease in dependence on their concentration. Compounds can be used daily only in recommended doses (higher doses can be toxic), but still will not replace a healthy diet. People need a varied diet to be healthy, in which are all necessary nutrients, what Hippocrates demonstrated long ago “Let food be the medicine, and let medicine be the food.” This book is written for students who select bioorganic chemistry subject during the study of general medicine or dentistry as well as for motivated students who would like to practice their knowledge and wish to improve in this subject and for students who would like to learn simplified basic organic reactions with their future application in biochemistry. Learn the simple models mainly through creative simple instruction by using different colours, by repetition, practice by drawing of formulas by hand (at least three times) and memorization of common names of compounds and their reactions which have application in biochemistry. Thus, establishing simple educational methods how to distinguish organic molecules according to the colours of a functional group can promote universal learning for all students who thought that chemistry is a difficult subject, but hopefully they change their opinion after study of this book.

Keywords: organic molecules, oxygen, sulfur, nitrogen derivatives of hydrocarbons, heterocyclic compounds, chemical reactions, isomerism of organic compounds

THE FUNCTION OF METAPHOR IN MEDIEVAL NEOPLATONISM

THE FUNCTION OF METAPHOR IN MEDIEVAL NEOPLATONISM

E-book

E-book

Mária Mičaninová - Ivica Hajdučeková (eds.)

In the framework of the project VEGA of the Ministry of Education, Science, Research and Sport of the Slovak Republic 1/0330/12 The Function of Metaphor in the Philosophy of Shlomo ben Yehuda ibn Gabirol and Shihab al-Din Yahya al-Suhrawardi, project leader Assoc. Prof. Mária Mičaninová, CSc., under the patronage of the rector of Pavol Jozef Šafárik University in Košice, The Slovak Republic, Prof. MUDr. Ladislav Mirossay, DrSc., and of The Department of Philosophy and History of Philosophy of the Faculty of Arts of the same University, took place on 4th – 5th October 2013 an International conference on The Function of Metaphor in Medieval Neoplatonism. Two days´conference was opened by Dean of the Faculty of Arts of P. J. Šafárik University, Prof. PhDr. Ján Gbúr, CSc.,in the presence of Prof. PhDr. Vladimír Leško, CSc., Head of The Department of Philosophy and History of Philosophy, and of foreign guests and students of the University.

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Cell Biophysics II

Cell Biophysics II

E-book

E-book

Katarína Štrofeková

Cell Biophysics II is the one semester comprehensive course textbook for PhD students. It encompasses basic principles and mechanisms underlying cell physiology and biophysics with aims:

• General knowledge of the principles of cellular function, including membrane, cytoplasmic and nuclear roles in normal and abnormal conditions.
• In-depth understanding of the mechanisms underlying the cell functions at the molecular and subcellular level.
• Awareness of cell pathologies that lead to specific disease symptoms and phenotypes.
• The ability to apply learned principles to solve new problems (analysis & synthesis).

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100 years of the koruna

100 years of the koruna

€30.69
Availability: 1 In Stock

Vladimír Tomšík et al.

The book was prepared to mark an important anniversary – one hundred years of our national currency. It was written by a team of Czech National Bank experts headed by CNB Vice-Governor, Professor Vladimír Tomšík. This publication charts the monetary policy history of our central bank (or, to use older terminology, the bank of issue) and describes its institutional development and the banknotes it has issued over time. It covers the period from the establishment of the independent Czechoslovak state in October 1918 and its currency in February 1919 to the present. We have therefore named the publication 100 years of the koruna. Given the twists and turns of history, however, part of the narrative relates to the joint Czechoslovak state, part to the occupied Protectorate and part to the independent Czech Republic. As a result, the original joint Czechoslovak currency was divided temporarily in 1939–1945 and then again – this time for good – in 1993. From that point on, the currencies of the two successor states went their own ways, the Czech koruna continuing to the present day and the Slovak koruna until it was replaced by the single European currency in 2009.

Regionalism and Its Contribution to General International Law

Regionalism and Its Contribution to General...

E-book

E-book

Ján KlučkaĽudmila Elbert

The present monograph "Regionalism and its Contribution to General International Law" was written at the Institute of European Law and Department of International Law, Faculty of Law, Pavol Jozef Safarik University in Kosice, as a part of the project (APVV-O823-11) carried out in 2011-2015, representing one of its final publication utputs. 

The main reason for choosing the topic was to evaluate regionalism in its various relationships and forms with respect to international law, and also to evaluate the place,importance and duties of international law in respect to the establishment and functioning of various forms of regionalgroups.

It is a fact that even though a lot of attention has been paid to regionalism, a more complex evaluation of the impact it has had on international law, and vice versa, is still lacking. The efforts of the present monograph are to partially eliminate this gap.

After giving a brief insight into how regionalism has developed, its content and terminology, the monograph studies in more details individual types of regionalism in the form of old and new regionalism, as well as treaty and institutional regionalism; its specifications and contributions to the international law.

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Realism, Modernism, Postmodernism: Five Modern Literary Texts in Context

Realism, Modernism, Postmodernism: Five Modern...

E-book

E-book

Soňa Šnircová

This textbook has been designed as supporting material for the postgraduate course on modern trends in European literature. It focuses on the presentation of five modern literary modes of writing: the realistic mode which was brought to its prominence by the nineteenth-century Realist movement; the stream-of-consciousness and ‘absurdist’ modes which were developed in the context of modernism; and the magical realist and metafictional modes which are associated mainly with postmodernist literary trends. Each mode is represented by a well-known text which demonstrates the formal aspects of each mode and deals with the thematic concerns typical of the literary movement that influenced its production.

The textbook adopts an interdisciplinary approach, placing the chosen literary texts into the historical, philosophical and cultural contexts that shaped their characters, and thereby providing the background knowledge necessary for a deeper understanding of their formal and thematic aspects.

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Nursing care  - clinical procedure I

Nursing care - clinical procedure I

€14.60
Availability: 10 In Stock

Gabriela Štefková - Mária ZamboriováMária Sováriová SoósováRenáta Shafout

We would like to introduce the study material/textbook Nursing Care Clinical Procedures I, which was developed to cover the curriculum of Nursing Care 1 for medical students. Clinical procedures are an essential component of nursing practice. The textbook contains four main chapters. Each chapter begins with a general explanation of the topic, followed by detailed method description of procedures to help students deliver high - quality care to patients. Some chapters also include appendi xes in order to pick up some special examples from clinical practice. The textbook strongly describes bandages because a carelessly or improperly applied bandage can cause discomfort to the patient, in many cases it may expose the wound to the danger of infection. To the best of wound knowledge, these procedures reflect currently accepted clinical practice and up-to-date information. The textbook can be easily integrated into an educational programme and can be used in the laboratory as well as in clinical practice. During the preparation of this textbook the information, facts, notes, publications, books and literature presented in the references section were also used. The publication include DVD, which is concentrated on applying bandages from head to lower extremity. DVD was developed in cooperation during IRES project. The student can also find additional information to study by following references. The reading level of Nursing Care Clinical Procedures I is designed to be comprehensible to as many students as possible, including those for whom Engl ish is a second language. We hope that this textbook will be useful to all readers. The authors take no personal responsibility for applying this information to a particular clinical practice
situation.

Essentials of Language Typology

Essentials of Language Typology

E-book

E-book

Lívia Körtvélyessy

This university textbook explains to students enrolled in the course Linguistic Typology and Universals the basic terminology, theoretical approaches, and research methods. The textbook is divided into eleven chapters. Each chapter presents theoretical knowledge in an accessible manner, along with practical exercises aimed at developing students’ skills in the respective area.

The textbook covers the following topics: the subject and nature of linguistic typology, a brief history of this linguistic discipline, genealogical classification of languages, various approaches and main objectives of typology across different linguistic levels (phonology, morphology, syntax, and lexicon), as well as areal typology, complex issues of language universals, and the nature and essence of typologists’ work. Given the extensive research activities of linguists from the Department of British and American Studies at Pavol Jozef Šafárik University in Košice, the textbook also introduces students to the results achieved by these scholars in this rapidly developing field of linguistics.

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Cognitive neuroscience of auditory and cross-modal perception - Lectures and assignments

Cognitive neuroscience of auditory and...

E-book

Norbert Kopčo - Frederick Gallun - Beáta Tomoriová - Ľuboš Hládek(eds.)

Cognitive neuroscience is a fast developing scientific field which aims at uncovering the neural basis of human perception and cognition. To achieve this goal, cognitive neuroscience uses a variety of tools and approaches ranging from non-invasive brain imaging to psychophysics and neural modeling. Mastering such tools requires skills and knowledge from multiple scientific domains, including neurophysiology, cognitive psychology, and several computational fields.

Access on request via email: kogneuro (@) gmail.com

http://pcl.upjs.sk/workshopcd 

https://sites.google.com/site/kogneuro/

Compendium of Hygiene

Compendium of Hygiene

€18.10
Availability: 109 In Stock

 Kvetoslava Rimárová 

The theme of the presented university textbook is a summary of selected basic knowledge of hygiene - environmental medicine. The script includes significant areas of environmental medicine as a science: the basics of environmental medicine, health and prevention issues of environmental health and risk assessment of potential exposure, the issue of air pollution, indoor pollution, problems of drinking water, the action of soil and solid waste, further issue of housing, nutrition and the impact of working conditions on health. Nutritional factors textbooks dealing with issues of rational nutrition, describe the individual components of nutrition, but also address the issue of food hygiene and the possibilities of foodborne infections. One chapter is also devoted to the impact of environmental conditions on health of children and youth. 

University textbook as a manuscript consists from 199 manuscript pages, is divided into 12 basic chapters, contains 36 citations in the literature.  In the Preface, the issue of categorization of diseases and define the basic concepts of health, prevention. Other chapters deal with the above selected chapters hygiene.

This university textbook comes as a basic university textbook for students of general  medicine in the English language, for students of bachelor's and master's studies  of medical schools - mainly bachelor's and master' program of  "Public health". Students of medicine and dentistry can also use these textbooks as an educational tool in the study of other subjects in the teaching of public health.

Autor

Basic Principles of Cardiac Surgery

Basic Principles of Cardiac Surgery

€13.16
Availability: 29 In Stock

František Sabola kol.

Although we are not really sure if “Love is coming from the Heart” and nor we know where “the Residence of Soul” is, we are still overwhelmed by its unprecedented effort to keep us alive. Our lives are nowadays fulfilled with enormous chances to satisfy our needs and wishes. Hand in hand is changing our way of life, the intake of calories is growing and the amount of physical activity decreasing. We live longer and maybe happier but our hearts
and vessels are like mirrors showing us how we live. Diseases of the Heart and vessels have become the number one cause of death in highly developed countries including our homeland.
Prevention of cardiovascular diseases has become and an important social and health care system issue. The knowledge requirement of basic principles of cardiology and heart surgery is increasing. Without an understanding of basic principles a good clinical practice is hardly possible.
Together with my Colleagues of Heart surgery department of VÚSCH and LF UPJŠ we prepared this short overview of basic knowledge about surgery of the human heart. We hope that reading it will be more an adventure than a painful journey. If you find some answers to your unanswered questions our effort was not a waste of time.

Authors

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