Elementary organic molecules in biochemistry

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Miriam Kozárová

The publication "News in Diabetology and Lipidology" focuses on extremely relevant topics in diabetology and lipidology, reflecting the state of these issues in light of the recommendations from professional societies from 2019. In diabetology, it primarily addresses the intensification of antidiabetic treatment using modern drug classes—specifically, incretin enhancers and sodium-glucose cotransporter-2 (SGLT-2) inhibitors (gliflozins). Few medical fields have experienced such a development of new pharmacological options as diabetology has in the last two decades. While pharmacotherapy for type 2 diabetes (DM2) was limited to the use of biguanides, sulfonylurea derivatives, and insulin throughout the second half of the last century, recent years have introduced entirely new groups of oral antidiabetics with cardio- and nephroprotective effects. In lipidology, it pertains to the new recommendations from the European Atherosclerosis Society (EAS) with new treatment goals for serum lipids and lipoproteins, including the use of biological therapies.

This textbook is primarily intended for medical students in doctoral studies and doctoral candidates, as well as for physicians preparing for specialization exams in internal medicine, endocrinology, diabetology, metabolic disorders and nutrition, as well as cardiology and angiology. I believe that readers will find information in this publication that will aid them in their studies and translate into their daily clinical practice.

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Štefan Tóth

Dyslipidemia is one of the main risk factors for the development of cardiovascular diseases. In recent years, extensive research has been conducted, leading to changes in therapeutic recommendations for dyslipidemia. These scripts aim to provide readers in the introductory chapters with information on the basic management of patients with dyslipidemia, procedures, target levels, and available medications and their combinations for achieving target levels, focusing on the practical aspect of dyslipidemia treatment. In the special section of the script, an overview is provided of the basic characteristics, studies of individual available hypolipemics, as well as hypolipemics that are not yet on our market or are still in the stage of clinical trials

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Ingrid Hodorová a kol. 

„Pracovný zošit z anatómie“ je určený pre výučbu študentov nelekárskych bakalárskych odborov ako doplnkový študijný materiál. Z dôvodu, že študenti uvedených odborov nemajú možnosť kontaktu s reálnymi anatomickými štruktúrami je pre nich výučba predmetu anatómie neatraktívna. Veríme, že predkladaný pracovný zošit so svojimi ilustráciami anatomických štruktúr umožní študentom aktívnejšie sa zapojiť do vyučovacieho procesu, čím sa pre nich predmet anatómie stane prístupnejší a atraktívnejší.

Kolektív autorov

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Denisa Harvanová (ed.)

The proceedings contain abstracts submitted by participants of the international scientific event entitled "MVDr. Ján Rosocha, CSc. Memorial" (3rd year). The event is part of a bilateral project named: "Extracellular vesicles: a promising cell-free therapy for cartilage repair (SK-AT-23-0005)", which is implemented within the framework of cooperation between Pavol Jozef Šafárik University in Košice, Slovakia, and the University for Continuing Education Krems in Austria. It is funded by the Slovak Research and Development Agency (APVV) under the bilateral call Slovakia-Austria 2023 and by OEAD – Agency for Education and Internationalisation under the project number SK11/2024. The MVDr. Ján Rosocha, CSc. Memorial (3rd year) was held on October 14, 2025, on the premises of the Faculty of Medicine, P. J. Šafárik University in Košice, Slovak Republic.

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Tatiana Kimáková a kol.

Ethics, as the science of the proper realization of human potential in various areas of life, also extends into the environment. For understanding the ethical aspects in this field, a thorough knowledge of the individual components of the environment, as well as their impact not only on humans but on all living nature, is very important. Therefore, questions concerning the influence of the environment are increasingly at the forefront of interest from an ethical perspective, also in connection with existing legal norms.

The modern process of civilization is characterized by rapid development of science and technology. However, this development, while raising the standard of living on one hand, also brings negative side effects on the other. The result is the disruption of ecological, biological, and natural life conditions, especially in the areas of industrial centers. The development of individual branches of industry leads to the production of liquid, gaseous, and solid wastes, the emergence of harmful risk factors threatening various components of living nature, including humans. There may be increased bioaccumulation of hazardous chemical elements in organisms, which, through their effects, represent a potential risk also in terms of carcinogenesis and mutagenesis.

For this reason, an important role of society is to create conditions to prevent the release of emissions and to reduce their concentration to the lowest possible, socially and biologically acceptable level. The assessment of the biological effects of harmful substances is based on experimental and epidemiological studies. Knowledge of concentration and duration of exposure is crucial for applying dose-effect relationships and for determining the highest permissible concentrations of pollutants. The health of the population, as a universal value and a primary human right, represents a fundamental economic resource not only for the individual, but also for society as a whole.

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Tatiana Muchová

Medicína stále napreduje, je stále vo vývoji. Rádiologické zobrazovacie metódy prežívajú stále výrazný rozvoj vďaka prístrojovej technike, ktorá umožňuje zavádzať nové diagnostické metódy, ako sú USG vyšetrenia s kontrastnou látkou, špeciálne CT vyšetrenia, ku ktorým je potrebný viacradový CT prístroj – CT angiografia, CT enteroklýza, CT irigografia, CT virtuálna kolonoskopia. Magnetická rezonancia už v dnešnej dobe nie je nedostupné vyšetrenie, predstavuje výrazný pokrok v diagnostike.

Vďaka moderným prístrojom môžeme vykonávať rôzne intervenčné diagnostické aj terapeutické výkony, ako sú biopsie, drenáže...

Tieto učebné texty sú určené študentom lekárskych fakúlt, obsahuje základné poznatky z rádiológie.

Publikácia je rozdelená na všeobecnú a špeciálnu časť s následným delením podľa jednotlivých modalít a vyšetrovaných orgánov.

Rádiológia predstavuje prácu s obrazovou dokumentáciou, preto aj táto publikácia je obohatená veľkým počtom obrázkov z jednotlivých rádiologických vyšetrovacích modalít.

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Tatiana Kimáková - Vladimír Pavlík

The scientific monograph focuses on the characteristics of free radicals, reactive oxygen and nitrogen species, oxidative stress, and its impact on various diseases. A significant portion is dedicated to antioxidants, their classification based on multiple criteria, the characteristics of selected antioxidants in terms of their functions, manifestations of their deficiency and excess, and the overall antioxidant capacity of the body.

A special section is devoted to enzyme-based antioxidants, natural sources of antioxidants in the form of vitamins, trace elements, flavonoids, polyphenols, and coenzyme Q10. To provide a clearer understanding of antioxidants and their influence on population health, the monograph presents results from a research project included in the program "Research Support for Enhancing the Defense Capabilities of the Czech Republic in NATO Structures."

The research was conducted between 2010 and 2012 as part of preventive rehabilitation programs for professional soldiers with a sports component. The study involved 218 professional soldiers, including 180 men and 38 women, with an average age of 33.3 years. The current health status and dietary habits of the soldiers were assessed using questionnaires.

The study described the saturation of the observed group with antioxidant vitamins and statistically evaluated the relationship between their levels and the risk indicators for the development of cardiovascular diseases. Individual analyses were performed using the Reflotron device calibrated with Reflotron Precinorm control serum. Following blood collection, all participants underwent anthropometric examinations (body weight, height, waist circumference), blood pressure measurements, heart rate monitoring, and physical fitness assessments through simple functional tests.

This scientific monograph is suitable for the scientific community, students of medical, veterinary, and natural sciences, as well as public health students at all levels of university education. It is also intended for informed members of the public.

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Andrea Madarasová Gecková - Daniela Husárová a kol.

The aim of this publication is to present the latest findings of the international study Health Behavior in School-aged Children (HBSC), regarding the health and health-related behavior of school-aged children in Slovakia.After four years, it again brings information on various topics covering physical and mental health, nutritional behavior, leisure-time activities, use of psychoactive substances, within social environment of school-aged children, including family, school and peers. The publication also presents newfindings connected to objectively measured physical fitness of these children. Finally, data about school-aged children with special educational needs are also presented.The findings play an important role in understanding the needs of the new generation of adolescents and are an important source of information for all those who work with them, not only professionals but also parents.Last but not least, they are also beneficial for all stakeholders and institutions who participate in the preparing of policies and strategies focused on supporting the health of school-aged children.

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Terézia Kisková - Stanislav Matéffy - Františka Horváthová

The laboratory rat (Rattus norvegicus) is one of the most commonly used experimental animals. It serves as a model organism for analyzing numerous biological processes and pathological mechanisms, such as cardiovascular diseases, metabolic disorders (e.g., lipid metabolism, diabetes mellitus), neurological and neuropsychiatric conditions (e.g., stroke, epilepsy, or Alzheimer's disease), neurobehavioral research, autoimmune diseases (e.g., arthritis), cancer, and renal diseases. It offers many unique advantages for modeling human diseases, testing drugs and natural substances, and studying responses to environmental factors. The size of the laboratory rat, compared to the mouse, creates ideal conditions for physiological manipulations. Additionally, rats are used in clinical toxicology to test chemical substances (Hedrich, 2000).

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Mária Rašiová

Cardiovascular diseases are among the main causes of morbidity and mortality in developed countries. Academic textbook: Selected Chapters from Angiology is devoted to the most common vascular diseases that the angiologist encounters on a daily basis.

Dilated artery diseases (abdominal aortic aneurysm), as well as stenotizing diseases of peripheral arteries, are described. Diseases such as deep vein thrombosis, thrombophlebitis and chronic venous insufficiency are discussed in the venous vascular system section. I also deal with the most common lymphatic vascular system disease ˗ lymphoedema.

In the individual chapters the risk factors of the diseases, symptoms and signs, diagnostics, treatment modalities (pharmacological therapy, endovascular therapy, angiosurgical therapy) and possible complications of the therapy are briefly analyzed.

My priority was to present the information in a logical, interesting and comprehensible form for students and for common clinical practice.

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Iveta Domoráková - Štefan Tóth - Zuzana Fagová - Kristína Čurgali - Viera Eliášová - Alexandra Kunová - Monika Holodová

The peer-reviewed textbook and microscopic atlas is aimed at understanding the basic microscopic structure of cells and tissues in a light microscope. Texts in the textbook are complemented by a rich set of histologic micrographs with basic and specific staining techniques.

All histologic micrographs were prepared by the author's team at the Department of Histology and Embryology, Faculty of Medicine, UPJŠ.

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Jozef Kafka

Význam vedomia pre každého človeka ale aj pre pozná­vanie je taký rozhodujúci, že by bolo nesprávne hovoriť o ňom iba pri psychických procesoch, lebo je jadrom ľudskej individuality a práve vedomím sa človek odlišuje od ostat­ných živých tvorov.

Je potešujúce, že nová oblasť poznávania označovaná ako veda o mysli začína sa vedomím zaoberať podrobnejšie a vylučuje tvrdenia, že vedomie nejestvuje hoci zatiaľ hovorí podľa mojej mienky iba o bazálnom vedomí a jej inter­pretácie prekračujú zistené fakty.

V svojej odbornej činnosti a aj v učebniciach som rozlišoval dve cesty poznávania vedomia a  iba postupne som si uvedomil, že mám pred sebou dva úrovne vedomia. V tejto práci  rozlišujem tieto dve úrovne:

• bazálne vedomie,
• rozvinuté vedomie.

Ak bazálne vedomie vyjadruje bdenie a spánok, tiež po­zornosť a gnostické rozpoznávanie, teda  idiognózia a somatognózia, rozvinuté vedomie predpokladá reč a vytvára také prejavy, ktoré označujeme ako duševné, teda identita, sebareali­záciu, čo vyjadruje schopnosť uvedomovania si seba, okolia, spoločnosti ale aj všetkého čo sme schopní poznať.

Také chápanie je blízke výkladu fyziológa Pavlova o dvoch signálnych sústavách a chápaniu Poppera o treťom sve­te ale aj ďalšie náhľady, nikto však neurobil určitejšie závery a nedošiel k náhľadu, že naše vedomie má dvojvrstevnú podobu, dve úrovne.

Napriek rozsiahlej a takmer neprehľadnej literatúre vieme o vedomí málo, okrem toho, že je to schopnosť uvedomo­vania, teda schopnosť uvedomiť si, že jestvujem, že som, že jest­vujú aj iní ľudia, že jestvuje niečo čo označujeme ako svet ako nepredstaviteľný vesmír. Uvedomujem si, že som individua­litou jedinečnou, ale limitovanou narodením a smrťou a že mám aj zmysel svojho bytia. Toto uvedomovanie, akokoľvek spo­chybňované je pre človeka prítomné v jeho poznávaní, hoci nemáme zmysly, ktorými by sme vedeli lokalizovať jeho prí­tomnosť v mozgu, ale svojou charakteristikou s dynamikou a integráciou má však duševný charakter, odlišný od    ostatných preja­vov mozgovej činnosti.

Práca sa pokúša v deviatich kapitolách osvetliť, čo sa chápe pojmom bazálne a rozvinuté vedomie    a možno ju rozdeliť do troch okruhov:

V prvých šiestich kapitolách diela hovorí o vedomí ako o doméne bytia človeka, podáva sa preto výklad vedomia a jeho rozlíšenie, potom sa hovorí o kolobehu života a rozvoji ve­domia, kladie sa otázka vedomia u stavovcov, potom náhľady filozofické a metodológia skúmania vedomia. Nasledujú ďalšie kapitoly, ktoré analyzujú podrobnejšie dve formy, úrovne vedomia, sú to kapitoly 7-9, začínajú ana­lýzou individuality človeka, lebo to je báza vedomia aj je­ho foriem, ďalej kapitoly o bazálnom vedomí a rozvinu­tom vedomí, čo považujem za jadro predkladanej práce. Napokon sa opisujú niektoré poruchy vedomia, ktoré dokladajú realitu vedomia v podobe  jej porúch ale aj možnosti rozlí­šenia dvoch úrovní, ktoré sa dajú zistiť pri starostlivom štúdiu a pri práci s chorými.

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Ladislav Kočan - Dušan Rybár - Róbert Rapčan

The autonomic nervous system is a vital component of the peripheral nervous system, responsible for maintaining homeostasis and regulating internal processes within the body. Unlike the voluntary control exerted by the central nervous system, the autonomic nervous system operates involuntarily, innervating smooth organs, vessels, skin glands, and even exerting some influence over skeletal muscles in connection with vegetative functions such as breathing, digestion, and the urinary and gonadal systems. Its impact extends crucially to the cardiac muscles of the heart and plays a significant role in endocrine and metabolic functions, thermoregulation, as well as emotional and behavioral responses, including adaptive reactions to stressors.

The aim of this publication is to provide a comprehensive and objective exploration of the anatomical and physiological intricacies of the autonomic nervous system, offering insights into its clinical applications. Within these pages, we meticulously delineate various interventional therapeutic procedures tailored to specific diagnoses related to the autonomic nervous system, aligning each intervention with the anatomical framework of the autonomic system. The efficacy of these procedures is evaluated based on the level of evidence, as per the current recommendations of Evidence-Based Medicine.

This publication is primarily crafted for fifth and sixth-year medical students and medical professionals specializing in anesthesiology, intensive care, and pain medicine. It serves as a valuable resource for gaining a deeper understanding of autonomic nervous system function and its clinical implications, facilitating informed decision-making in clinical practice.

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A.A. Ahmetova - A.A. Seidakhmetova - N.D. Kalmenov et al.

Improving the best practices in the provision of the first pre-medical care is one of the priority areas of clinical medicine in most countries of the world. Despite the success in improving the provision of medical care at the level of FPMA and emergency medical care, it is the provision of skilled care at the earliest stages of the disease or emergency conditions that determines the quality of all medical care and the future of the patient.

When rendering emergency care to the sick and injured, the time factor is very important, it prevents irreversible disturbances in the body and creates a good help for the complete cure of the patient. Textbook is designed to improve awareness of the importance of pre-medical aid to non-medical students in central Asian countries.

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E-publikácia

Dorota Sopková

Forensic Medicine is a medical discipline that is concerned with determination of the cause of death in cases violent and non-violent deaths by performing an autopsy. It is based on morphological findings, which characterize the effects of various forms of violence, as well as pathological changes in various diseases. The presented textbook provides comprehensive and complete overview of the fundamental tasks and theoretical knowledge of the field of forensic medicine. Its aim is to provide a theoretical basis in the form of images of morphological autopsy findings for the study of the compulsory subject Forensic Medicine and Medical Law in the study programs General Medicine and Dentistry. The author emphasizes the necessity to understand the fundamentals of forensic medicine in every medical field and a multidisciplinary approach in clarifying medico-legal issues.

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