Antioxidanty a ich význam v prevencii chronických ochorení

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Tatiana Kimáková a kol.

Ethics, as the science of the proper realization of human potential in various areas of life, also extends into the environment. For understanding the ethical aspects in this field, a thorough knowledge of the individual components of the environment, as well as their impact not only on humans but on all living nature, is very important. Therefore, questions concerning the influence of the environment are increasingly at the forefront of interest from an ethical perspective, also in connection with existing legal norms.

The modern process of civilization is characterized by rapid development of science and technology. However, this development, while raising the standard of living on one hand, also brings negative side effects on the other. The result is the disruption of ecological, biological, and natural life conditions, especially in the areas of industrial centers. The development of individual branches of industry leads to the production of liquid, gaseous, and solid wastes, the emergence of harmful risk factors threatening various components of living nature, including humans. There may be increased bioaccumulation of hazardous chemical elements in organisms, which, through their effects, represent a potential risk also in terms of carcinogenesis and mutagenesis.

For this reason, an important role of society is to create conditions to prevent the release of emissions and to reduce their concentration to the lowest possible, socially and biologically acceptable level. The assessment of the biological effects of harmful substances is based on experimental and epidemiological studies. Knowledge of concentration and duration of exposure is crucial for applying dose-effect relationships and for determining the highest permissible concentrations of pollutants. The health of the population, as a universal value and a primary human right, represents a fundamental economic resource not only for the individual, but also for society as a whole.

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Ingrid Madárová - Lívia Barnišinová - Veronika Pálová

Táto učebnica je určená pre zahraničných študentov medicíny – začiatočníkov – ako slovenčina na špecifický účel výučby. Jej cieľom je pomôcť zahraničným študentom, ktorí (1) študujú medicínu (2) v cudzom jazyku (anglický jazyk) a (3) v zahraničí (Slovensko) zvládnuť výzvu pri príprave na praktickú časť ich štúdia – konverzácia s pacientom v Slovenskom jazyku.Zámerom je poskytnúť študentom krok za krokom najfrekventovanejšie slovné spojenia a výrazy potrebné pri komunikácii s pacientom. Lekcie sa zameriavajú hlavne na slovnú zásobu týkajúcu sa častí ľudského tela a na základné symptómy a príznaky chorôb.Dôraz je kladený na krátke dialógy medzi lekárom a pacientom. Pri precvičovaní dialógov sú študenti vedení k nácviku komunikácie so zreteľom na porozumenie, bez prípadných obáv o gramatickú správnosť. Gramatické javy sú predstavované postupne, cez jednoduché  pomôcky – „tipy“.V prípade potreby si môžu študenti nájsť a doplniť si „chýbajúce časti gramatiky“ prostredníctvom odkazov na odporúčanú literatúru. Cieľom tejto knihy je uľahčiť a zefektívniť celý proces štúdia/osvojenia si (lekárskej) slovenčiny.

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Martina Čižmáriková - Peter Takáč 

It is known that pharmacology is a rapidly evolving medical field, with information about drug forms and their routes of administration constantly changing. In addition to the emergence of new drug forms, new trends are also observed in the routes of administration suitable for delivering drugs. Despite being significant factors influencing the efficacy and safety of pharmacotherapy – an indispensable component of comprehensive patient care – to our knowledge, there has been a lack of comprehensive and detailed textual material focused on this issue on the market. This fact is related to the broader scope of the professional text we are presenting, as rare drug forms or less commonly used routes of administration are only marginally mentioned or not mentioned at all in available pharmacology textbooks.

Our main goal was therefore to provide sufficient information about existing drug forms, their routes of administration, as well as their methods of delivery, which should serve to enhance the quality of pharmacotherapy in the context of so-called "tailored treatment," whose main effort is to individualize treatment for a specific patient. Although the work focuses on drug application methods, a detailed description of the technical implementation of algorithms and other related procedures is the subject of interest for other fields (nursing, surgical propaedeutics, etc.). Overall, it is a supplementary educational text provided in electronic form, which is extremely popular in today's modern informatized era. Thanks to this, the work can be used at any time at home or in a school environment, comprehensively or progressively, partially. We have also tried to enhance its quality by appropriate content organization, inclusion of practical experiences, as well as the inclusion of colorful images or photographs, overview tables, and appendices.

The textbook is supplemented by test quizzes serving to verify acquired selected knowledge, which are published on the website of the Department of Pharmacology at the Medical Faculty of UPJŠ in Košice (under "Teaching" → "Taught subjects"), and which will be continuously supplemented and updated (http://www.lf.upjs.sk/farmakologia/TEST%201.htm; http://www.lf.upjs.sk/farmakologia/TEST%202.htm).

Although the work is primarily intended for medical students, or students of pharmacy and other healthcare fields, we firmly believe that enriching information will be found in it by beginning graduates of these fields, as well as their teachers.

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Peter Berek 

S vývojom endovaskulárnej chirurgie dochádza postupne k rozvoju stentingu ACI. Minimálne invazívny prístup spravil túto metodiku vhodnú pre pacientov s vážnymi konkomitatnými kardiálnymi alebo pľúcnymi ochoreniami. Ďalšou výhodou v porovnaní s chirurgickou liečbou bol lepší prístup k ACI u pacientov po rádioterapii, po predchádzajúcich operáciách na krku, ale aj u pacientov so stenózami blízko lebečnej bázy. Porovnanie CEA vs CAS je zaujímavou a diskutabilnou témou mnohých štúdií. Avšak, aj napriek celosvetovému mohutnému rozvoju endovaskulárnej liečby karotická endarterektómia ostáva zlatým štandardom liečby stenózy ACI u symptomatických aj asymptomatických pacientov.

V tejto monografii by sme radi akcentovali a systematizovali problematiku chirurgickej prevencie CMP z pohľadu cievneho chirurga.

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Peter Berek

With the development of endovascular surgery, there is a gradual advancement in ACI stenting. The minimally invasive approach has made this methodology suitable for patients with serious concomitant cardiac or pulmonary diseases. Another advantage compared to surgical treatment was better access to the ICA in patients after radiotherapy, after previous neck surgeries, as well as in patients with stenoses close to the skull base.

The comparison of CEA vs CAS is an interesting and debatable topic in many studies. However, despite the massive global development of endovascular treatment, carotid endarterectomy remains the gold standard for treating ICA stenosis in both symptomatic and asymptomatic patients. In this monograph, we would like to accentuate and systematize the issue of surgical stroke prevention from the perspective of a vascular surgeon.

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Helena Mičková -  Jozef Židzik -  Mária Mareková - Marek Stupák - 

Peter Urban

Modelové otázky na prijímacie skúšky pre bakalárske štúdium sú určené záujemcom o bakalárske študijné programy na Univerzite Pavla Jozefa Šafárika v Košiciach, Lekárskej fakulte. Publikácia obsahuje 500 otázok z biológie a 500 otázok z chémie, ktoré tvoria podklady písomných testov na prijímacie skúšky. Otázky na prijímacích skúškach však nemusia presne kopírovať modelové otázky. Testy z chémie a biológie pokrývajú tie okruhy učiva z predmetov biológia a chémia na slovenských gymnáziách, vedomosti z ktorých sú vyžadované od poslucháčov bakalárskych študijných smerov (napr. ošetrovateľstvo, fyzioterapia, verejné zdravotníctvo). Otázky z biológie a z chémie sú predkladané v dvoch samostatných celkoch. Odpovede na otázky sú riešené formou ponúkaných variantných odpovedí, obsahujúcich správne aj nesprávne možnosti. Správne odpovede sú vyznačené v kľúči na konci publikácie.

Príklady z chémie tvoria zvláštnu časť, v ktorej nie sú ponúkané variantné odpovede. Pre lepšiu kontrolu správnosti výpočtu je v zátvorke uvedený jeden správny výsledok (z viacerých možných – líšiacich sa napr. v jednotkách – gramy, miligramy, móly). Autori publikácie sa snažili minimalizovať možné chyby v texte a vyhnúť sa nejednoznačným formuláciám otázok a odpovedí. Modelové otázky sú okrem prípravy na prijímacie skúšky na UPJŠ LF v Košiciach vhodné aj na zopakovanie gymnaziálneho učiva z biológie a chémie pred maturitnou skúškou.

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Kvetoslava Rimárová

This manual is published as an auxiliary methodological script for students of bachelor and master courses of medical faculties - especially bachelor and master courses of ‘Public Health’.

Students of general medicine and dentistry can also use these teaching texts as an educational aid when studying the subject “Hygiene”, which is taught either on its own or as part of broader subjects, e.g. “Public Health”. 

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Erik Dosedla

Laparoscopic surgical techniques are among the most frequently performed operations today. Throughout their short history, they have undergone many modifications, mainly related to miniaturization and the development of computer technology. The rapid development of laparoscopy over the last twenty years has led to changes in the indications, with minimally invasive procedures gradually replacing standard classical procedures.

Laparoscopic surgery offers significant benefits to the patient, but it also increases the demands on the surgical team.

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Štefan Tóth

Dyslipidemia is one of the main risk factors for the development of cardiovascular diseases. In recent years, extensive research has been conducted, leading to changes in therapeutic recommendations for dyslipidemia. These scripts aim to provide readers in the introductory chapters with information on the basic management of patients with dyslipidemia, procedures, target levels, and available medications and their combinations for achieving target levels, focusing on the practical aspect of dyslipidemia treatment. In the special section of the script, an overview is provided of the basic characteristics, studies of individual available hypolipemics, as well as hypolipemics that are not yet on our market or are still in the stage of clinical trials

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Ivana Skoumalová - Zuzana Dankulincová

The publication entitled Competencies for clinical practice in the field of communication with the patient serves as the background and teaching material.

The text is structured to bring theoretical knowledge about the topic, current research findings in the field and practical tips for training skills in practice. It provides clear information on individual parts of the training and is designed to acquire knowledge that is the basis for practical skills in medical communication, especially in communication with patients.

It is intended for general and dental students to deepen their knowledge and acquire missing skills in medical communication, which are evidence-based and research-validated skills that have a demonstrable positive impact on patient communication.

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Monika Halánová-Leonard Siegfried

Although chronic non-communicable diseases currently dominate overall morbidity and mortality in developed countries, epidemics of infectious diseases, especially those caused by new or emerging pathogens, occur more frequently and spread faster and further in new territories. The starting factors of this threat are mainly ecological and climatic changes and changes in human demography and behaviour. The growing resistance to ATB is also very serious, as a result of which there is a significant increase in the incidence of infectious diseases and their spread to new geographical locations. Current problems of epidemiology and microbiology in research and clinical practice are mainly focused on rapid detection and subsequent response to diagnosed diseases. The correct diagnosis of an infectious disease is the result of a clinical picture, knowledge of the current epidemiological situation and laboratory confirmation of the etiological agent. The identification of microorganisms allows us to establish the correct definitive diagnosis and subsequent targeted therapy, but also to start immediately with appropriate anti-epidemic measures to control the spread of the infectious agent.

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Miriam Kozárová

The publication "News in Diabetology and Lipidology" focuses on extremely relevant topics in diabetology and lipidology, reflecting the state of these issues in light of the recommendations from professional societies from 2019. In diabetology, it primarily addresses the intensification of antidiabetic treatment using modern drug classes—specifically, incretin enhancers and sodium-glucose cotransporter-2 (SGLT-2) inhibitors (gliflozins). Few medical fields have experienced such a development of new pharmacological options as diabetology has in the last two decades. While pharmacotherapy for type 2 diabetes (DM2) was limited to the use of biguanides, sulfonylurea derivatives, and insulin throughout the second half of the last century, recent years have introduced entirely new groups of oral antidiabetics with cardio- and nephroprotective effects. In lipidology, it pertains to the new recommendations from the European Atherosclerosis Society (EAS) with new treatment goals for serum lipids and lipoproteins, including the use of biological therapies.

This textbook is primarily intended for medical students in doctoral studies and doctoral candidates, as well as for physicians preparing for specialization exams in internal medicine, endocrinology, diabetology, metabolic disorders and nutrition, as well as cardiology and angiology. I believe that readers will find information in this publication that will aid them in their studies and translate into their daily clinical practice.

Author

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Iveta Domoráková - Štefan Tóth - Zuzana Fagová - Eva Mechírová - Alexandra Kunová - Kristína Čurgali - Viera Eliášová - Monika Holodová - Marianna Danková

In our new electronic textbook, FUNDAMENTALS OF HISTOLOGY II – Textbook and Atlas of Microscopic Anatomy of Organs, we present students and the professional public with essential information about the microscopic structure of organs, accompanied by extensive visual documentation of organ structures and clear legends for the microphotographs.

All histological specimens come from the archive of the Institute of Histology and Embryology, are used in practical exercises, and are also included in teaching presentations. The electronic textbook is intended for undergraduate and postgraduate students of general medicine and dentistry at medical faculties, as well as for students of veterinary medicine and pharmacy, and biology students at faculties of natural sciences.

The textbook is designed so that students can find clear explanations of most medical terms and also reinforce their knowledge of professional terminology in Latin. An advantage of the electronic textbook is the ability to enlarge microscopic photographs, allowing detailed observation of structures without any qualitative loss of the viewed image. The microphotographs used in the atlas were taken with the following equipment: Zeiss Promicra and Olympus BX50 with a Canon EOS 2000D digital camera and QP Industrial 3.2 software.

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Ján Varga

The cancer is the second most common reason of the death in human population. lt is responsible for approximately 10 million of death every year. Oncogynecology represents · one of the most pr ogressive part of gynecology. The interest is focused on vulvar cancer, vaginal cancer, cervical cancer, uterine cancer, fallopian tube carcinoma, ovarian cancer as well as breast cancer. Due to the range of the issue there are own workplaces ta king care just for the patients with oncogyneco logical diseases. The knowledge from oncogynecology are inevitably needed to pass the state exam as well as specialization from Gynecology and obstetrics. The presented publication is focused to mentioned oncogynecological diseases.

The anatomy and histology of the vulva, vagína, cervix, uterus, fallop ian tube and ovary are described in detail. Every described carcinoma contains part about etiopathogenesis, clinical presentation, diagnostic, classification and therapy. The paper contains information suitable for students of medical faculties as well as young doctors before specialization.

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E-publication

Jaroslav Majerník - Andrea Kačmariková

The university textbook "Databases in MS Access – accompanying texts for practical exercises" is intended for medical students, students of non-technical universities, and all beginners in working with databases. It introduces the reader to the issues of database processing and explains the basic principles that need to be known when creating relational databases. It is therefore suitable for those who have not yet worked with databases or who are considering managing their data using their own database. However, even more experienced computer users can find useful information here. This university textbook is written in such a way that its content can be mastered with basic knowledge of working with computers and programs running in any version of the MS Windows operating system.

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Martina Zavacká a kolektív

Kniha „DIABETICKÁ NOHA Z POHĽADU CIEVNEHO CHIRURGA“ obsahuje 14 kapitol. Pojednáva o syndróme diabetickej nohy z multidisciplinárneho pohľadu viacerých odborníkov: angiochirurga, diabetológa, chirurga, podiatra, röntgenológa, neurológa a algeziológa. Úvodné kapitoly majú charakter propedeutiky, čo má taktiež význam aj pre pregraduálnu výchovu. Nasledujúce kapitoly sa zaoberajú vznikom syndrómu, výskytom, jeho diagnostikou, terapeutickými postupmi, pridruženými postihnutiami neurologického charakteru, starostlivosťou podiatra a algeziológa pri pretrvávaní bolestí. Ďalšie časti sú vyhradené chirurgickej a endovaskulárnej liečbe tepien cestou cievneho chirurga a intervenčných angiológov. Nezabúdajúc na problematiku amputácií a správnu rehabilitáciu pacientov s diabetom.  V knihe nájdu poučenie cievni chirurgovia, angiológovia, všeobecní chirurgovia, diabetológovia, neurológia, röntgenológovia, podiatri  a všeobecní lekári.

Kniha je zdrojom najnovších teoretických i praktických informácií pre postgraduálnu výchovu vyššie spomenutých odborníkov.

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