Nové poznatky v SMAD dependentnej dráhe transformujúceho rastového faktora u pacientov s kolorektálnym karcinómom

E-book

Jana Mašlanková

Colorectal carcinoma is the most common malignant tumor of the digestive system, and its rising incidence in Slovakia—particularly among the male population—is alarming. Although significant progress has been made in the diagnosis, screening, and treatment of patients with advanced colorectal cancer, therapeutic options remain limited, necessitating the discovery of additional markers to serve as prognostic predictors.

This monograph aims to draw the attention of the professional community to the critical role and significance of the TGF-β signaling pathway in the initiation, progression, and treatment of colorectal carcinoma. A substantial portion of the text focuses on lesser-known emerging trends and ongoing clinical trials for colorectal cancer patients.

The monograph aspires to provide a balanced resource that serves as an engaging informational tool not only for specialist physicians but also for medical faculty students. By integrating novel insights and clinical data, it seeks to bridge gaps in current understanding and highlight potential avenues for future research and therapy.

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978-80-574-0238-1

Data sheet

Method of publication:
E-book (pdf)
Author:
Jana Mašlanková
Document type:
Monograph
Number of pages:
65
Available from:
22.09.2023
Year of publication:
2023
Edition:
1st edition
Publication language:
Slovak
Faculty:
Faculty of Medicine
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ATLAS OF FORENSIC MEDICINE: Autopsy findings in...

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Forensic Medicine is a medical discipline that is concerned with determination of the cause of death in cases violent and non-violent deaths by performing an autopsy. It is based on morphological findings, which characterize the effects of various forms of violence, as well as pathological changes in various diseases. The presented textbook provides comprehensive and complete overview of the fundamental tasks and theoretical knowledge of the field of forensic medicine. Its aim is to provide a theoretical basis in the form of images of morphological autopsy findings for the study of the compulsory subject Forensic Medicine and Medical Law in the study programs General Medicine and Dentistry. The author emphasizes the necessity to understand the fundamentals of forensic medicine in every medical field and a multidisciplinary approach in clarifying medico-legal issues.

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Anatómia trupu a končatín

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At present, there is a wide range of anatomy textbooks for medical students but at the same time there is an absence of anatomy books suitable for dental students. This book was designed as a base for study of trunk and limbs for dental students which should gain a sense of anatomy structures, but they do not need know details from these regions.

The amount of information in the book was extensively discussed with colleagues from clinical departments and with anatomy specialists from Slovakia and from abroad as well. Because of serious diversity of opinions we took into consideration also opinions of our specialists from dental medicine. Final material is considered to be a key information required for future dental doctors.

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Základy histológie I. Učebnica a mikroskopický...

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The peer-reviewed textbook and microscopic atlas is aimed at understanding the basic microscopic structure of cells and tissues in a light microscope. Texts in the textbook are complemented by a rich set of histologic micrographs with basic and specific staining techniques.

All histologic micrographs were prepared by the author's team at the Department of Histology and Embryology, Faculty of Medicine, UPJŠ.

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Chirurgická liečba cerebrovaskulárnej...

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S vývojom endovaskulárnej chirurgie dochádza postupne k rozvoju stentingu ACI. Minimálne invazívny prístup spravil túto metodiku vhodnú pre pacientov s vážnymi konkomitatnými kardiálnymi alebo pľúcnymi ochoreniami. Ďalšou výhodou v porovnaní s chirurgickou liečbou bol lepší prístup k ACI u pacientov po rádioterapii, po predchádzajúcich operáciách na krku, ale aj u pacientov so stenózami blízko lebečnej bázy. Porovnanie CEA vs CAS je zaujímavou a diskutabilnou témou mnohých štúdií. Avšak, aj napriek celosvetovému mohutnému rozvoju endovaskulárnej liečby karotická endarterektómia ostáva zlatým štandardom liečby stenózy ACI u symptomatických aj asymptomatických pacientov.

V tejto monografii by sme radi akcentovali a systematizovali problematiku chirurgickej prevencie CMP z pohľadu cievneho chirurga.

Aktuálne problémy epidemiológie a mikrobiológie...

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Although chronic non-communicable diseases currently dominate overall morbidity and mortality in developed countries, epidemics of infectious diseases, especially those caused by new or emerging pathogens, occur more frequently and spread faster and further in new territories. The starting factors of this threat are mainly ecological and climatic changes and changes in human demography and behaviour. The growing resistance to ATB is also very serious, as a result of which there is a significant increase in the incidence of infectious diseases and their spread to new geographical locations. Current problems of epidemiology and microbiology in research and clinical practice are mainly focused on rapid detection and subsequent response to diagnosed diseases. The correct diagnosis of an infectious disease is the result of a clinical picture, knowledge of the current epidemiological situation and laboratory confirmation of the etiological agent. The identification of microorganisms allows us to establish the correct definitive diagnosis and subsequent targeted therapy, but also to start immediately with appropriate anti-epidemic measures to control the spread of the infectious agent.

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Vybrané kapitoly z infektológie

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Ivana Hockicková-Ondrej Zahornacký

The textbook „Selected chapters in Infectology“ is a comprehensive study material about selected infectious diseases for students of medicine as well as other healthcare professions. It is primarily intended for students of general and dental medicine. It is the first textbook of its kind, aiming to provide students with comprehensive information about different types of infectious diseases, including their causes, typical symptoms, diagnostics, treatment and prevention. It is divided into a total of 18 chapters. The textbook is written in accordance with the latest knowledge about infectious diseases and serves as the foundation for success in the Infectology subject.

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Dve úrovne vedomia: bazálne a rozvinuté vedomie

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Význam vedomia pre každého človeka ale aj pre pozná­vanie je taký rozhodujúci, že by bolo nesprávne hovoriť o ňom iba pri psychických procesoch, lebo je jadrom ľudskej individuality a práve vedomím sa človek odlišuje od ostat­ných živých tvorov.

Je potešujúce, že nová oblasť poznávania označovaná ako veda o mysli začína sa vedomím zaoberať podrobnejšie a vylučuje tvrdenia, že vedomie nejestvuje hoci zatiaľ hovorí podľa mojej mienky iba o bazálnom vedomí a jej inter­pretácie prekračujú zistené fakty.

V svojej odbornej činnosti a aj v učebniciach som rozlišoval dve cesty poznávania vedomia a  iba postupne som si uvedomil, že mám pred sebou dva úrovne vedomia. V tejto práci  rozlišujem tieto dve úrovne:

  • bazálne vedomie,
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Ak bazálne vedomie vyjadruje bdenie a spánok, tiež po­zornosť a gnostické rozpoznávanie, teda  idiognózia a somatognózia, rozvinuté vedomie predpokladá reč a vytvára také prejavy, ktoré označujeme ako duševné, teda identita, sebareali­záciu, čo vyjadruje schopnosť uvedomovania si seba, okolia, spoločnosti ale aj všetkého čo sme schopní poznať.

Také chápanie je blízke výkladu fyziológa Pavlova o dvoch signálnych sústavách a chápaniu Poppera o treťom sve­te ale aj ďalšie náhľady, nikto však neurobil určitejšie závery a nedošiel k náhľadu, že naše vedomie má dvojvrstevnú podobu, dve úrovne.

Napriek rozsiahlej a takmer neprehľadnej literatúre vieme o vedomí málo, okrem toho, že je to schopnosť uvedomo­vania, teda schopnosť uvedomiť si, že jestvujem, že som, že jest­vujú aj iní ľudia, že jestvuje niečo čo označujeme ako svet ako nepredstaviteľný vesmír. Uvedomujem si, že som individua­litou jedinečnou, ale limitovanou narodením a smrťou a že mám aj zmysel svojho bytia. Toto uvedomovanie, akokoľvek spo­chybňované je pre človeka prítomné v jeho poznávaní, hoci nemáme zmysly, ktorými by sme vedeli lokalizovať jeho prí­tomnosť v mozgu, ale svojou charakteristikou s dynamikou a integráciou má však duševný charakter, odlišný od    ostatných preja­vov mozgovej činnosti.

Práca sa pokúša v deviatich kapitolách osvetliť, čo sa chápe pojmom bazálne a rozvinuté vedomie    a možno ju rozdeliť do troch okruhov:

V prvých šiestich kapitolách diela hovorí o vedomí ako o doméne bytia človeka, podáva sa preto výklad vedomia a jeho rozlíšenie, potom sa hovorí o kolobehu života a rozvoji ve­domia, kladie sa otázka vedomia u stavovcov, potom náhľady filozofické a metodológia skúmania vedomia. Nasledujú ďalšie kapitoly, ktoré analyzujú podrobnejšie dve formy, úrovne vedomia, sú to kapitoly 7-9, začínajú ana­lýzou individuality človeka, lebo to je báza vedomia aj je­ho foriem, ďalej kapitoly o bazálnom vedomí a rozvinu­tom vedomí, čo považujem za jadro predkladanej práce. Napokon sa opisujú niektoré poruchy vedomia, ktoré dokladajú realitu vedomia v podobe  jej porúch ale aj možnosti rozlí­šenia dvoch úrovní, ktoré sa dajú zistiť pri starostlivom štúdiu a pri práci s chorými.

Vybrané kapitoly z detskej kardiológie

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To offer our medical students of 5th and 6th classes as well as to professional public (pediatrics, pediatric cardiologists) integrated information from pediatric cardiology, which is based on scientific knowledge of experts and practical requirements including our experiences. The publication will extend given the discipline of cardiovascular risk factors of cardiovascular heart disease and acquired heart diseases, which are more actual at the present time in the children as we as bring the new didactic methods in pediatric cardiology teaching.

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Štúdie zdravotného a nutričného stavu populácie...

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Kvetoslava Rimárová

This manual is published as an auxiliary methodological script for students of bachelor and master courses of medical faculties - especially bachelor and master courses of ‘Public Health’.

Students of general medicine and dentistry can also use these teaching texts as an educational aid when studying the subject “Hygiene”, which is taught either on its own or as part of broader subjects, e.g. “Public Health”. 

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Tatiana Kimáková

This scientific monograph is a comprehensive scientific work focused on the presence and effects of mercury in the environment, as well as the health risk factors associated with it.

The monograph presents a characterization of mercury in a multidisciplinary scope, discusses its use in industry and healthcare, and describes the negative impacts of mercury on the environment and public health. It also provides proposals and recommendations for at-risk groups. The monograph includes a comprehensive study of mercury concentration in samples of domestic and foreign production commodities and plant samples using the atomic absorption spectrometer AMA 254.

This scientific monograph is suitable for the scientific community, students of medical, veterinary, natural sciences, and agricultural fields, as well as public health students at all three levels of university study. It is also intended for all interested members of the informed public.

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Psychology in Medicine

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Martina Ružičková - Jozef Dragašek

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Psychology is becoming increasingly important in people's lives. It is significant to research human behaviour and how people interact with their environment, as well as how they develop physically, mentally, emotionally, and socially. A rising number of people have been both physically and mentally harmed in recent years as a result of cognitive, emotional, or behavioural disorders.

It was determined that a study book on psychology for medical students was required. Presented study book Psychology in Medicine gives students a fundamental insight into patients´ behaviour in general, and demonstrates the role of psychology in relieving health concerns in particular. It includes topics of medical psychology and clinical psychology that are applied in health care. The chapters address the basic principles of human behaviour, communication between patients and physicians, personality psychology, psychodiagnostic techniques, psychotherapy treatment, abnormal psychology, dealing with stressful events and physical illnesses. The study textbook also emphasises the importance of good mental health and self-care in a doctor's practise.

There is a hope that this book will provide both a source of information and inspiration for doctors and all health care professionals.

Student scientific international conference...

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Martina Šemeláková (ed.)

Proceedings contain abstracts from participants of the scientific conference with international participation under the name: Student scientific international conference GenICa”, supported by the project "Bilateral relations and common knowledge between Slovakia and Iceland research at Universities on the topic "Genomic instability and cancer "GenICa", funded under the EEA and Norwegian 2014-2021 Financial Mechanism Programme (FBR02, bilateral initiatives under the Fund for Bilateral Relations at national level co-financed by EEA and Norwegian Financial Mechanism 2014-2021) which took place on 19 - 21 June 2024 in the premises of Hotel Sorea Trigan, Štrbské Pleso, Slovakia.

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Ošetrovateľstvo v chirurgii I

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Silvia DankováLucia Dimunová - Beáta Grešš HalászJana Sušinková

The present multimedia university textbook is intended for students of the bachelor's degree programme in nursing, not excluding both medical and nursing degree courses.

The purpose of the present publication is to provide a comprehensive view of the nature of surgical nursing, focusing on the method of providing nursing care - the nursing process. It comprehensively describes the individual steps of perioperative nursing care and the subsequent possible complications associated with surgical procedures. Documents the depth of knowledge and skills training in chronic wound care management issues. Respects the culture of patient and healthcare professional safety.

The college textbook uses e-learning methods in combination with traditional face-to-face education. Based on the latest resources, it respects the concept of health care delivery and professional training of nurses.

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Environment a jeho etické aspekty

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Tatiana Kimáková a kol.

Ethics, as the science of the proper realization of human potential in various areas of life, also extends into the environment. For understanding the ethical aspects in this field, a thorough knowledge of the individual components of the environment, as well as their impact not only on humans but on all living nature, is very important. Therefore, questions concerning the influence of the environment are increasingly at the forefront of interest from an ethical perspective, also in connection with existing legal norms.

The modern process of civilization is characterized by rapid development of science and technology. However, this development, while raising the standard of living on one hand, also brings negative side effects on the other. The result is the disruption of ecological, biological, and natural life conditions, especially in the areas of industrial centers. The development of individual branches of industry leads to the production of liquid, gaseous, and solid wastes, the emergence of harmful risk factors threatening various components of living nature, including humans. There may be increased bioaccumulation of hazardous chemical elements in organisms, which, through their effects, represent a potential risk also in terms of carcinogenesis and mutagenesis.

For this reason, an important role of society is to create conditions to prevent the release of emissions and to reduce their concentration to the lowest possible, socially and biologically acceptable level. The assessment of the biological effects of harmful substances is based on experimental and epidemiological studies. Knowledge of concentration and duration of exposure is crucial for applying dose-effect relationships and for determining the highest permissible concentrations of pollutants. The health of the population, as a universal value and a primary human right, represents a fundamental economic resource not only for the individual, but also for society as a whole.

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Vyšetrovacie metódy v internej medicíne

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Ivana ValočíkováIvana Jochmanová a kolektív

Cieľom projektu KEGA je vydanie vysokoškolskej učebnice, ktorá sa zaoberá vyšetrovacími metódami vo vnútornom lekárstve. Vhodne zvolené vyšetrovacie metódy sú popri fyzikálnom vyšetrení a podrobnej anamnéze pilierom diagnostiky jednotlivých chorôb. Poznanie, ale najmä adekvátne používanie vyšetrovacích metód patrí k základným znalostiam každého lekára. V súčasnosti nie je na Slovensku dostupná žiadna publikácia s komplexným prehľadom vyšetrovacích metód vo vnútornom lekárstve. Tento typ učebnice by sa takto mohol stať základným zdrojom pre získanie informácií o možnostiach, výbere, použití jednotlivých vyšetrovacích metód pri jednotlivých chorobách vo vnútornom lekárstve. Publikácia bude slúžiť ako študijný materiál pre študentov v pregraduálnej forme štúdia, ale aj v rámci špecializačného štúdia. Učebnica bude praktickým pokračovaním vysokoškolskej učebnice „Interná propedeutika“, ktorá bola vydaná v rámci riešenia KEGA projektu 022UPJŠ-4/12011 v rokoch 2011 -2013. Učebnica bola vydaná v r. 2014, druhé vydanie učebnice bolo začiatkom  roku 2022.

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