Všeobecná patofyziológia

E-book

Martina Čižmáriková - Peter Takáč 

It is known that pharmacology is a rapidly evolving medical field, with information about drug forms and their routes of administration constantly changing. In addition to the emergence of new drug forms, new trends are also observed in the routes of administration suitable for delivering drugs. Despite being significant factors influencing the efficacy and safety of pharmacotherapy – an indispensable component of comprehensive patient care – to our knowledge, there has been a lack of comprehensive and detailed textual material focused on this issue on the market. This fact is related to the broader scope of the professional text we are presenting, as rare drug forms or less commonly used routes of administration are only marginally mentioned or not mentioned at all in available pharmacology textbooks.

Our main goal was therefore to provide sufficient information about existing drug forms, their routes of administration, as well as their methods of delivery, which should serve to enhance the quality of pharmacotherapy in the context of so-called "tailored treatment," whose main effort is to individualize treatment for a specific patient. Although the work focuses on drug application methods, a detailed description of the technical implementation of algorithms and other related procedures is the subject of interest for other fields (nursing, surgical propaedeutics, etc.). Overall, it is a supplementary educational text provided in electronic form, which is extremely popular in today's modern informatized era. Thanks to this, the work can be used at any time at home or in a school environment, comprehensively or progressively, partially. We have also tried to enhance its quality by appropriate content organization, inclusion of practical experiences, as well as the inclusion of colorful images or photographs, overview tables, and appendices.

The textbook is supplemented by test quizzes serving to verify acquired selected knowledge, which are published on the website of the Department of Pharmacology at the Medical Faculty of UPJŠ in Košice (under "Teaching" → "Taught subjects"), and which will be continuously supplemented and updated (http://www.lf.upjs.sk/farmakologia/TEST%201.htm; http://www.lf.upjs.sk/farmakologia/TEST%202.htm).

Although the work is primarily intended for medical students, or students of pharmacy and other healthcare fields, we firmly believe that enriching information will be found in it by beginning graduates of these fields, as well as their teachers.

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Jaroslav Majerník - Andrea Kačmariková

The university textbook "Databases in MS Access - accompanying texts for practical exercises" is intended for students of medical faculties, students of non-technical universities and all beginners in working with databases. It introduces the reader to the issue of database data processing and explains the basic principles that need to be known when creating relational databases. It is therefore suitable for those who have not yet worked with databases, or who have started thinking about managing their data using their own database.

However, even more "experienced" computer users can find useful information here. The university textbook is written in the way that its content can be mastered with basic knowledge of working with computers and programs running in the environment of MS Windows operating system.

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E-book

Marianna Vitková

Current classification of demyelinating diseases of the central nervous system according to van der Knaap and Valko from 2005 includes 97 congenital and acquired diseases that cause demyelination of the white matter of the brain and spinal cord. Most of these disorders lacks any definitive diagnostic test, so the accurate diagnosis depends on upon clinical symptoms, course of the disease, neurological findings, and the results of neuroimaging and laboratory examinations.

The aim of this textbook is to provide an accurate overview of acquired demyelinating diseases of the CNS, their etiopathogenesis, clinical picture and diagnostic options.

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Alžbeta Blichárová - Ľudmila Verbóová - Zuzana Benetinová - Vladimír Tancoš  - Patrícia Kollárová  - Adam Nedoroščík - Erika Štammová  - Pavel Kočan

“Pathology Part 2 (summer semester) - Practical lessons for students of general medicine” represents the second half of the university textbook designed for the pregradual study of pathology. The textbook complements the lectures of pathology and serves as a source of information for students of general medicine, that are preparing for the practical credit, as well as the final oral examination.

In this part of the “Pathology” series, seventy selected histopathological slides are presented. Each selected slide is provided with general information in relation to etiology and pathogenesis of the disease, as well as with corresponding morphological features, including the gross appearance and the most important histopathological characteristics. The textbook summarizes the basic concepts of systemic (organ) pathology (pathology of the lungs, hematopoietic, gastrointestinal, urogenital system, breast, endocrine, musculoskeletal, nervous system, skin childhood and infancy), that is logical continuation and completion of general pathology in the first semester.

Keywords: systemic pathology – histopathological slides – general medicine – gross appearance – microscopic image

Rastislav Dudič

Vysokoškolská učebnica je svojim rozsahom, obsahom, formou a spôsobom spracovania určená pre študentov bakalárskeho študijného programu Fyzioterapia. Je zameraná na získanie základných vedomostí z oblasti gynekológie a pôrodníctva.

Učebnica pozostáva z dvoch hlavných kapitol: vybrané kapitoly z gynekológie a vybrané kapitoly z pôrodníctva. Prvá kapitola je členená na 6 podkapitol. Autor v nich uvádza anatómiu ženských genitálií, základy gynekologického vyšetrenia, zápaly ženských pohlavných orgánov a sexuálne prenosné ochorenia. Záver prvej kapitoly je venovaný benígnym a malígnym nádorovým ochoreniam ženských genitálií. Druhá kapitola je členená tiež na 6 podkapitol, v ktorých autor sa venuje prenatálnej starostlivosti, uloženiu plodu v maternici, pôrodu, pridruženým ochoreniam v tehotenstve a potratom.

Učebnica je napísaná v rozsahu 83 strán. Uvedený text obsahuje 35 obrázkov, 9 tabuliek, zoznam skratiek a značiek a zoznam použitej literatúry. Autor cituje 35 prevažne zahraničných citácií.

E-book

Terézia Kisková - Stanislav Matéffy - Františka Horváthová

The laboratory rat (Rattus norvegicus) is one of the most commonly used experimental animals. It serves as a model organism for analyzing numerous biological processes and pathological mechanisms, such as cardiovascular diseases, metabolic disorders (e.g., lipid metabolism, diabetes mellitus), neurological and neuropsychiatric conditions (e.g., stroke, epilepsy, or Alzheimer's disease), neurobehavioral research, autoimmune diseases (e.g., arthritis), cancer, and renal diseases. It offers many unique advantages for modeling human diseases, testing drugs and natural substances, and studying responses to environmental factors. The size of the laboratory rat, compared to the mouse, creates ideal conditions for physiological manipulations. Additionally, rats are used in clinical toxicology to test chemical substances (Hedrich, 2000).

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Ivana Valočíková - Ivana Jochmanová a kolektív

Cieľom projektu KEGA je vydanie vysokoškolskej učebnice, ktorá sa zaoberá vyšetrovacími metódami vo vnútornom lekárstve. Vhodne zvolené vyšetrovacie metódy sú popri fyzikálnom vyšetrení a podrobnej anamnéze pilierom diagnostiky jednotlivých chorôb. Poznanie, ale najmä adekvátne používanie vyšetrovacích metód patrí k základným znalostiam každého lekára. V súčasnosti nie je na Slovensku dostupná žiadna publikácia s komplexným prehľadom vyšetrovacích metód vo vnútornom lekárstve. Tento typ učebnice by sa takto mohol stať základným zdrojom pre získanie informácií o možnostiach, výbere, použití jednotlivých vyšetrovacích metód pri jednotlivých chorobách vo vnútornom lekárstve. Publikácia bude slúžiť ako študijný materiál pre študentov v pregraduálnej forme štúdia, ale aj v rámci špecializačného štúdia. Učebnica bude praktickým pokračovaním vysokoškolskej učebnice „Interná propedeutika“, ktorá bola vydaná v rámci riešenia KEGA projektu 022UPJŠ-4/12011 v rokoch 2011 -2013. Učebnica bola vydaná v r. 2014, druhé vydanie učebnice bolo začiatkom  roku 2022.

Andrea Madarasová Gecková - Daniela Husárová a kol.

The aim of this publication is to present the latest findings of the international study Health Behavior in School-aged Children (HBSC), regarding the health and health-related behavior of school-aged children in Slovakia.After four years, it again brings information on various topics covering physical and mental health, nutritional behavior, leisure-time activities, use of psychoactive substances, within social environment of school-aged children, including family, school and peers. The publication also presents newfindings connected to objectively measured physical fitness of these children. Finally, data about school-aged children with special educational needs are also presented.The findings play an important role in understanding the needs of the new generation of adolescents and are an important source of information for all those who work with them, not only professionals but also parents.Last but not least, they are also beneficial for all stakeholders and institutions who participate in the preparing of policies and strategies focused on supporting the health of school-aged children.

E-book

Jana Mašlanková

Colorectal carcinoma is the most common malignant tumor of the digestive system, and its rising incidence in Slovakia—particularly among the male population—is alarming. Although significant progress has been made in the diagnosis, screening, and treatment of patients with advanced colorectal cancer, therapeutic options remain limited, necessitating the discovery of additional markers to serve as prognostic predictors.

This monograph aims to draw the attention of the professional community to the critical role and significance of the TGF-β signaling pathway in the initiation, progression, and treatment of colorectal carcinoma. A substantial portion of the text focuses on lesser-known emerging trends and ongoing clinical trials for colorectal cancer patients.

The monograph aspires to provide a balanced resource that serves as an engaging informational tool not only for specialist physicians but also for medical faculty students. By integrating novel insights and clinical data, it seeks to bridge gaps in current understanding and highlight potential avenues for future research and therapy.

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E-book

Katarína Tokarčíková

The university textbook entitled "Vasculitis" provides a systematic overview of vasculitis encountered in clinical practice. The text is supplemented with tables reflecting the latest recommendations of professional societies and illustrations that aid in understanding the subject matter. The individual chapters analyze the etiopathogenesis of individual types of vasculitis, their epidemiology, clinical symptoms, diagnosis, differential diagnosis, treatment, prognosis and also prevention and screening options. The publication is intended for doctoral students at medical faculties, but it can also be used by doctors in specialist training in internal medicine, angiology, cardiology, rheumatology, nephrology and general medicine.

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E-book

Zuzana Mačeková - Zuzana Katreniaková a kol.

Demencia je jednou z naliehavých a mimoriadne zložitých globálnych výziev pre zdravotnícke a sociálne systémy 21. storočia. Na Slovensku sa počet osôb s demenciou odhaduje na 62 495 (2018), pričom sa predpokladá, že v roku 2040 tento počet vzrastie na 180 000. Demencie zatiaľ patria k nevyliečiteľným chronickým stavom, ktorým nie je možné úplne predchádzať. V roku 2024 (Livingston a kol.) bol publikovaný aktualizovaný model tzv. potenciálne ovplyvniteľných faktorov, ktoré môžu prispieť k zvýšenému riziku demencie. Patria k nim: nízka úroveň vzdelania, strata sluchu, vysoký LDL cholesterol, depresia, úrazové poranenie mozgu, fyzická nečinnosť, diabetes mellitus, fajčenie, vysoký krvný tlak, obezita, nadmerná konzumácia alkoholu, sociálna izolácia, znečistené ovzdušie (vrátane pasívneho fajčenia) a strata zraku. Týchto 14 rizikových faktorov predstavuje približne 45 % celosvetových demencií, ktorým by sa teoreticky dalo predísť. Napriek narastajúcej dostupnosti informácií, úroveň povedomia verejnosti o preventívnych prístupoch v správaní sa k sebe samým, ktoré môžu nástup demencie významne oddialiť, zostáva nízka. Farmaceuti na Slovensku majú v súčasnosti adekvátne kompetencie, aby vedeli pomôcť aj v oblasti prevencie demencií. Niekedy stačí poradenstvo priamo v lekárni, vo vážnejších prípadoch odporúčanie navštíviť lekára pre ďalšie posúdenie zdravotného stavu. Každopádne, človek takto nezostáva so svojim problémom sám a dostane včasnú a potrebnú zdravotnú starostlivosť.

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E-book

Marek Šoltés - Jozef Radoňak

Laparoscopic surgery today represents the standard and, in many respects, a preferred modality of surgical treatment. The dynamics of its global expansion, enabled by advancements in biomedical technologies and the development of global information and communication channels, is unprecedented in the history of surgery. Currently, there is virtually no abdominal operation that is not performed laparoscopically, with laparoscopic procedures often being the method of choice.

Despite—or perhaps because of—the unprecedentedly rapid penetration of laparoscopic surgeries into everyday surgical practice, universally accepted technical standards are still lacking in many respects. The high variability of procedural approaches within individual laparoscopic operations stems more from the traditions of specific workplaces than from evidence-based medicine. This situation is further influenced by the development of new and revived concepts such as mini-laparoscopy, SILS (Single Incision Laparoscopic Surgery), NOTES (Natural Orifice Transluminal Endoscopic Surgery), and their hybrid combinations with classical laparoscopy.

The aim of this monograph is to draw the attention of the professional community back to the fundamental principles of laparoscopic surgery, which should serve as a foundation for the effective and safe performance of laparoscopic operations, as well as a basis for a critical stance towards fashionable innovative trends.

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Marián Sabol - Helga Kostelná - Leonard Siegfried

Cieľom učebných textov je poskytnúť študentom medicíny a príbuzných odborov   poznatky o základných imunologických metódach, ktoré sa využívajú v klinickej praxi. V učebných textoch sú zahrnuté metódy na vyšetrenie fagocytózy, komplementu, imunoglobulínov, autoprotilátok,  HLA molekúl a T lymfocytov.  Súčasťou textov sú aj  postupy pre izoláciu a stanovenie počtu vybraných  typov buniek imunitného systému. Kombinácia klasických  metód (rozetové testy, fluorescenčná mikroskopia) a moderných metód   (napríklad prietoková cytometria a  ELISPOT) umožňuje orientáciu v základných laboratórnych metódach imunológie.

Ingrid Hodorová - Květuše Lovásová

The publication is a continuation of the already published university textbook"Ultrasound Anatomy 1" and fills the gap in the medical literary market concerning the ultrasound view of peripheral nerves and vessels of the limbs, and neck as well.

Lucia Dimunová et al.

Nutrition is among the fundamental needs of humans. A good nutritional status directly impacts an individual’s growth and development, health maintenance, and quality of life. This university textbook addresses nutrition in the context of dietetics and therapeutic nutrition, offering an overview of basic food components such as proteins, fats, carbohydrates, vitamins, and minerals.

It provides detailed insights into nutritional requirements across different developmental stages. In assessing nutritional status, it explores evaluation methods, including nutritional screening, anthropometric measurements, clinical assessments, and laboratory tests.

The text clarifies the structure of nutritional care systems for patients in home settings, healthcare facilities, and social institutions through a unified dietary system that defines basic and specialized diets. Alternative nutrition methods are discussed separately, with enteral and parenteral nutrition serving as alternatives during unfavorable health conditions.

The authors focus on application techniques and complications associated with these methods. The book concludes with food safety considerations and foundational principles of the European Union’s food policy. Currently, dietetics and therapeutic nutrition form a critical component of professional training for healthcare students in both undergraduate and postgraduate education, for whom this textbook is designed.

Authors’ Collective

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E-book

Jana Diabelková

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